nataliehauglund.bsky.social
Natalie hauglund
@nataliehauglund.bsky.social
51 followers 42 following 13 posts
Curious about sleep 💤
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Reposted by Natalie hauglund
leonsmyth.bsky.social
Leon Smyth @leonsmyth.bsky.social · Mar 2
Our News and Views on @nataliehauglund.bsky.social and Maiken Nedergaard's recent study showing how sleep drives brain waste clearance @cp-trendsimmuno.bsky.social

www.cell.com/trends/immun...
Rest and rinse: sleeping rhythms drive brain detox
Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Re...
www.cell.com
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Mar 10
Love the figures!! Great work 😄
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Reposted by Natalie hauglund
yukimori89.bsky.social
Yuki Mori @yukimori89.bsky.social · Feb 27
Fantastic 'Banana' Voyage! 🚀🍌 I'm practicing @napari.fosstodon.org.ap.brid.gy for my 'real' future scientific presentation. It's truly a fruitful software, and I'm excited to explore more of what I can do with it! :)
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 30
In conclusion, neuronal activity surrounding micro-arousals is complex and under strong homeostatic regulation. We still have a lot to learn about this mysterious feature of sleep!
Thanks to @vyazovskiy.bsky.social lab and co-authors for letting me play around with the amazing data 📊
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 30
5) Short (duration below 3 seconds) arousals tend to be associated with an overall decrease in firing rate, but not longer lasting arousals
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 30
4) Analysis of single channels within the cortical layers showed that some channels exhibit increased firing rates right before the micro-arousal while other channels have decreased firing during the micro-arousal
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 30
3) NREM sleep micro-arousals have different neuronal activity profiles than micro-arousals following REM sleep
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 30
2) slow wave activity (SWA) in a ~10s period immediately after micro-arousals is highly sensitive to sleep/wake history to an extent where post-arousal SWA is higher than NREM sleep SWA in sleep deprived mice
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 30
1) micro-arousals are associated with a decrease in power throughout the layers of the motor cortex
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 30
New preprint now online! www.biorxiv.org/content/10.1...

We created an algorithm to detect NREM sleep micro-arousals and used it to re-analyze LFP data from the motor cortex of sleeping mice 💤 This is what we found:
www.biorxiv.org
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Reposted by Natalie hauglund
giuliobernardi.bsky.social
Giulio Bernardi @giuliobernardi.bsky.social · Jan 20
New preprint from our lab, in collaboration with Jeff Duyn's group at NIH!! 🚨Bergamo et al., "Thalamic involvement defines distinct slow-wave subtypes in NREM sleep." Link: www.biorxiv.org/content/10.1...
Thalamic involvement defines distinct slow-wave subtypes in NREM sleep
Slow waves (0.5-4 Hz) are a key feature of non-rapid-eye-movement (NREM) sleep, traditionally believed to arise from neocortical circuits. However, growing evidence suggests that subcortical structure...
www.biorxiv.org
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 20
Awesome paper, really enjoyed reading it! Would be interesting to know if those C1 waves coincide with noradrenaline release 🤔
nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 13
Great write about our study in @nature.com 🧠
nature.com
Nature @nature.com · Jan 13
Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ

https://go.nature.com/3PwtwN2
How the brain cleans itself during deep sleep
Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ.
go.nature.com
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 10
If any of you have questions or comments or want do discuss the findings, please write! 😀 Let's have a journal club 😎
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 10
Furthermore, we find that the sleep aid Zolpidem (Ambien) disrupt the pumping system and impairs brain cleaning 🧠🚿
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nataliehauglund.bsky.social
Natalie hauglund @nataliehauglund.bsky.social · Jan 10
Out in @cellcellpress.bsky.social !
We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 www.cell.com/cell/fulltex...
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulations confirm that vasomotion, regulated by norepinephrine, acts as a pump for brain fluid transport.
www.cell.com
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