Nature Cancer
@natcancer.nature.com
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Publishing the latest advances across all areas of cancer research and oncology. Part of @natureportfolio.nature.com
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Nature Cancer
@natcancer.nature.com
· Sep 4
An MRI–pathology foundation model for noninvasive diagnosis and grading of prostate cancer - Nature Cancer
Shao et al. developed an MRI–pathology-based foundation model to assess the pathology of prostate cancer for diagnosis and grading of tumors. The model is noninvasive and outperforms current pathologi...
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Nature Cancer
@natcancer.nature.com
· Sep 3
Nature Cancer
@natcancer.nature.com
· Aug 29
Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity - Nature Cancer
Han et al. present TabulaTIME, a multicancer scRNA-seq resource, and report enrichment of extracellular matrix-related CTHRC1+ cancer-associated fibroblasts in proximity to SLPI+ macrophages, creating...
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Nature Cancer
@natcancer.nature.com
· Aug 29
A sphingolipid-derived paclitaxel nanovesicle enhances efficacy of combination therapies in triple-negative breast cancer and pancreatic cancer - Nature Cancer
Wang et al. designed sphingomyelin-derived vesicles that deliver paclitaxel to tumor site, improving its therapeutic efficacy and reducing associated toxicities, in mouse models of breast and pancreat...
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Nature Cancer
@natcancer.nature.com
· Aug 27
Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth - Nature Cancer
Li and colleagues report that a septo-enteric polysynaptic circuit that is activated by chronic stress links the brain to the tumor microenvironment to promote colorectal cancer growth.
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Nature Cancer
@natcancer.nature.com
· Aug 27
Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling - Nature Cancer
Vallentgoed et al. integrate clinical and multiomic data from persons with matched initial and recurrent IDH-mutant astrocytomas to identify progression-associated mechanisms and report a DNA methylat...
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Nature Cancer
@natcancer.nature.com
· Aug 27
Prospects for ferroptosis therapies in cancer - Nature Cancer
Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of cell death, as well a...
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Nature Cancer
@natcancer.nature.com
· Aug 5
The landscape of CAR-engineered innate immune cells for cancer immunotherapy - Nature Cancer
Dotti and colleagues review chimeric antigen receptor (CAR)-engineered cell-based cancer therapy and overview its transition for solid tumors from CAR T to CAR-engineered innate immune cells, discussi...
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Nature Cancer
@natcancer.nature.com
· Jul 30
Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer - Nature Cancer
Huang et al. analyzed serial samples from participants with metastatic non-small cell lung cancer treated with radiotherapy followed by immunotherapy and report improved clinical outcomes and enhanced...
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Nature Cancer
@natcancer.nature.com
· Jul 30
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit - Nature Cancer
Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS signaling enhances their an...
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Nature Cancer
@natcancer.nature.com
· Jul 10
Reposted by Nature Cancer
Fendt Lab
@fendtlab.bsky.social
· Jul 2
Will it be a turning point? - Nature Cancer
Sarah-Maria Fendt received her doctoral degree from ETH Zurich, Switzerland, and she conducted her postdoctoral research at the Massachusetts Institute of Technology, USA. She is currently a principal...
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Nature Cancer
@natcancer.nature.com
· Jul 7
IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages - Nature Cancer
Petroni et al. report that the infiltration of IL-17A-secreting γδ T cells in the tumor microenvironment coupled with the accumulation of immunosuppressive macrophages is associated with resistance to...
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Nature Cancer
@natcancer.nature.com
· Jul 4
Sentinel lymph node biopsy without systematic pelvic lymphadenectomy in females with early-stage cervical cancer: final outcome of the SENTIX prospective, single-arm, noninferiority, international tri...
Cibula et al. present survival results of the SENTIX trial and demonstrate that SLN biopsy alone does not increase the risk of disease recurrence in patients with early-stage cervical cancer.
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Nature Cancer
@natcancer.nature.com
· Jul 4
Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer - Nature Cancer
Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant trans...
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