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Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues - Nature Cardiovascular Research

Nature Cardiovascular Research @natcardiovascres.nature.com · 1d

Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes.
@DelbridgeLab
doi.org/10.1038/s441...
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Mellor et al. report that deficiency of GABARAPL1, an ATG8-specific linking protein, impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and a human organoid model of type 2 diabetes.

Nature Cardiovascular Research @natcardiovascres.nature.com · 16d

❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more!
www.nature.com/natcardiovas...

Image: Kathryn Berg. Cover design: Bethany Vukomanovic

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Nature Cardiovascular Research @natcardiovascres.nature.com · Aug 29

Our chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work

Excessive HIF-1α driven by phospholipid metabolism causes septic cardiomyopathy through cytopathic hypoxia - Nature Cardiovascular Research

Nature Cardiovascular Research @natcardiovascres.nature.com · Aug 19

Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy.
doi.org/10.1038/s441...

Watanabe et al. show that cytopathic hypoxia, through upregulation of COX2 and secretory PLA2, stabilizes HIF-1α, contributing to impaired mitochondrial respiration and reduced cardiac contraction in ...

Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current

Nature Cardiovascular Research @natcardiovascres.nature.com · Aug 13

❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more!
www.nature.com/natcardiovas...

Image: Heart and uterus image: Viarshyla Hanna / Alamy Stock Photo. Cover design: Bethany Vukomanovic

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Nature Cardiovascular Research @natcardiovascres.nature.com · Aug 12

Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation.
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doi.org/10.1038/s441...

Nature Cardiovascular Research - Zheng et al. generated a mouse model of phospho-ablation in all canonical ryanodine receptor 2 (RyR2) phosphorylation sites. They show that RyR2 phosphorylation at...

Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases

Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 29

Ding, Y., Chen, J., Liu, S. et al show that tetraspanin regulates the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport to balance Cdc42 and RhoA activities and influence vascular inflammation.

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Nature Cardiovascular Research - By regulating the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport, tetraspanin tunes the balance of Cdc42 and RhoA activities...

Identification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning - Nature Cardiovascular Research

Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 22

Research | Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts.

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Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layo...

The thrombin receptor PAR1 orchestrates changes in lymphatic endothelial cell junction morphology to augment lymphatic drainage during lung injury - Nature Cardiovascular Research

Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 17

Research| Chou et al. demonstrate that activation of the thrombin receptor PAR1 in the lung lymphatic vasculature augments lung lymphatic drainage in models of lung injury.

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Chou et al. demonstrate that activation of the thrombin receptor protease-activated receptor 1 in the lung lymphatic vasculature mediates morphological changes in lymphatic endothelial cell junctions ...

Premenstrual disorders and risk of cardiovascular diseases

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Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 15

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!

www.nature.com/natcardiovas...

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Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 11

Research | Yang et al draw evidence from population-based and sibling cohort studies to reveal that women suffering from premenstrual disorders are at an increased risk of cardiovascular disease.

doi.org/10.1038/s441...

Nature Cardiovascular Research - Yang et al. draw evidence from population-based and sibling cohort studies to reveal that women suffering from premenstrual disorders are at an increased risk of...

Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery

Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 8

Research | Jafari and colleagues reveal disease severity–linked right ventricle remodelling in pulmonary hypertension and identify key molecules, unveiling mechanisms of right ventricle recovery after pulmonary endarterectomy.

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Nature Cardiovascular Research - Through RNA profiling of right ventricular tissue from patients with chronic thromboembolic pulmonary hypertension, Jafari et al. uncover mechanisms underlying...

O-GlcNAcylation promotes angiogenic transdifferentiation to reverse vascular ischemia

Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 7

Research | Li, Lu et al. Demonstrate that O-GlcNAcylation enhances angiogenic transdifferentiation from fibroblasts to endothelial cells through a HIRE-dependent H3.3 deposition mechanism and facilitates vascular regeneration.

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Nature Cardiovascular Research - Li, Lu et al. demonstrate that O-GlcNAcylation enhances angiogenic transdifferentiation from fibroblasts to endothelial cells through a HIRA-dependent H3.3...

Multimodal AI to forecast arrhythmic death in hypertrophic cardiomyopathy - Nature Cardiovascular Research

Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 3

Research | Lai et al. present the machine learning model MAARS to predict arrhythmic sudden cardiac death from multimodal imaging and clinical data in patients with hypertrophic cardiomyopathy.

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Lai et al. present the machine learning model MAARS to predict arrhythmic sudden cardiac death from multimodal imaging and clinical data in patients with hypertrophic cardiomyopathy.

Maturation of human cardiac organoids enables complex disease modeling and drug discovery

Nature Cardiovascular Research @natcardiovascres.nature.com · Jun 30

Research | Pocock et al. reveal that transient activation of 5’ AMP-activated protein kinase and oestrogen-related receptor drives robust maturation of human cardiac organoids, enabling the modelling of desmoplakin cardiomyopathy. @qimrb.bsky.social

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Nature Cardiovascular Research - Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular...

Mechanosensitive PIEZO2 channels shape coronary artery development - Nature Cardiovascular Research

Nature Cardiovascular Research @natcardiovascres.nature.com · Jun 27

Research | Pampols-Perez et al. identify the mechanosensitive ion channel PIEZO2 as a marker for embryonic coronary artery endothelial cells and a regulator of coronary vascular remodelling and morphogenesis.

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Pampols-Perez et al. identify the mechanosensitive ion channel PIEZO2 as a novel marker for embryonic coronary artery endothelial cells and as a critical regulator of coronary vascular remodeling. The...

AIMP3 maintains cardiac homeostasis by regulating the editing activity of methionyl-tRNA synthetase - Nature Cardiovascular Research

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Nature Cardiovascular Research @natcardiovascres.nature.com · Jun 26

Research| Das et al. show that the correct editing activity of the methionyl tRNA synthetase, regulated by AIMP3, is required to prevent the accumulation of homocysteine and resulting cardiomyocyte death and cardiac dysfunction.

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Das et al. show that the correct editing activity of the methionyl tRNA synthetase, regulated by AIMP3, is required to prevent the accumulation of homocysteine and the resulting cardiomyocyte cell dea...

Epistasis regulates genetic control of cardiac hypertrophy - Nature Cardiovascular Research

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Nature Cardiovascular Research @natcardiovascres.nature.com · Jun 23

❤️Our June issue is out❤️Read about the insight from the LILACS trial on T-cell regulation in cardiology, empagliflozin’s role in protecting the kidney and preventing heart failure in the EMPACT-MI trial, and more!
www.nature.com/natcardiovas...

Image: Georgios Rovas, École Polytechnique Fédérale de Lausanne, 2025. Cover design: Bethany Vukomanovic

Nature Cardiovascular Research @natcardiovascres.nature.com · Jun 5

Research| Wang, Tang et al. develop an iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near the CCDC141, IGF1R, TTN, and TNKS loci.

doi.org/10.1038/s441...

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Wang, Tang and colleagues develop the low-signal signed iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near CCD...

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome - Nature Cardiovascular Research

Nature Cardiovascular Research @natcardiovascres.nature.com · Jun 3

Research| Case et al. report that low-dose interleukin-2 clonally expands Tregs and maintains their suppressive program by bypassing BACH2 downregulation in patients with acute coronary syndrome from the LILACS trial.
@aydencase.bsky.social

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By integrating single-cell transcriptomics and T cell receptor repertoire analyses of regulatory T (Treg) cells in a cohort of patients with acute coronary syndrome from the LILACS trial, Case et al. ...

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations - Nature Cardiovascular Research

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Nature Cardiovascular Research @natcardiovascres.nature.com · May 27

Research | Kraft et al. identify TIE2 activation as a key driver of PI3KCA-related venous malformations and demonstrate that inhibiting TIE2 signalling can suppress the growth of advanced lesions.

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Kraft et al. identify TIE2 activation as a key driver of PIK3CA-related venous malformations and demonstrate that inhibiting TIE2 signaling can suppress the growth of advanced lesions.

Mineralocorticoid receptor phase separation modulates cardiac preservation - Nature Cardiovascular Research

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Nature Cardiovascular Research @natcardiovascres.nature.com · May 22

Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function.

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Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function.

Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization

Nature Cardiovascular Research @natcardiovascres.nature.com · May 21

Research| Qian, Ugurlu, Fairweather, et al. generate more than 3800 #CardiacDigitalTwins from imaging and ECGs to reveal electrophysiological insights and their links to cardiac function, lifestyle, mental health and clinical outcomes.

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Nature Cardiovascular Research - Qian et al. used cardiac magnetic resonance images and electrocardiograms from the UK Biobank and an ischemic heart disease cohort and developed more than 3,500...