Nature Methods
@natmethods.nature.com
A scientific journal publishing cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Posts by the editors.
cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.
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January 9, 2026 at 4:57 PM
cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.
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SmartEM: a smart machine learning-based pipeline for electron microscopy-based data acquisition for connectomics.
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January 9, 2026 at 4:53 PM
SmartEM: a smart machine learning-based pipeline for electron microscopy-based data acquisition for connectomics.
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TransBrain translates brain phenotypes between mouse and human via homology mapping.
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January 9, 2026 at 4:50 PM
TransBrain translates brain phenotypes between mouse and human via homology mapping.
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January 8, 2026 at 8:44 PM
iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors, for tracking rapid dynamics and for recording from large populations of synapses.
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January 8, 2026 at 8:40 PM
iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors, for tracking rapid dynamics and for recording from large populations of synapses.
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A scalable, open source-framework can be used as a benchmarking suite for comparing macromolecular complex structure, interfaces and ligand interactions against experimental data.
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January 8, 2026 at 8:37 PM
A scalable, open source-framework can be used as a benchmarking suite for comparing macromolecular complex structure, interfaces and ligand interactions against experimental data.
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CELTIC: a context-dependent deep learning model for in silico organelle localization in label-free microscopy images.
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January 8, 2026 at 8:33 PM
CELTIC: a context-dependent deep learning model for in silico organelle localization in label-free microscopy images.
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Self-supervised reconstruction structured illumination microscopy allows long-term imaging of cellular processes.
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December 18, 2025 at 8:39 PM
Self-supervised reconstruction structured illumination microscopy allows long-term imaging of cellular processes.
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In this month's Creature Column, we feature the ascidian tunicate Ciona, a model for marine systems life sciences.
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December 18, 2025 at 8:25 PM
In this month's Creature Column, we feature the ascidian tunicate Ciona, a model for marine systems life sciences.
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December 18, 2025 at 8:21 PM
RFdiffusion2 builds de novo enzyme active sites using atom-level functional group constraints.
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December 11, 2025 at 5:01 PM
RFdiffusion2 builds de novo enzyme active sites using atom-level functional group constraints.
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CaBLAM: a bioluminescent, genetically encoded calcium indicator for high-contrast imaging in cells and in vivo.
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December 11, 2025 at 4:50 PM
CaBLAM: a bioluminescent, genetically encoded calcium indicator for high-contrast imaging in cells and in vivo.
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Parallelized single-molecule fluorescence and FRET experiments enable quantitative analysis of molecule function from multiple samples in a single experiment.
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December 11, 2025 at 4:41 PM
Parallelized single-molecule fluorescence and FRET experiments enable quantitative analysis of molecule function from multiple samples in a single experiment.
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ROSE-3D is a single-molecule localization microscopy method with high isotropic resolution, for whole-cell and multicolor imaging.
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December 11, 2025 at 4:31 PM
ROSE-3D is a single-molecule localization microscopy method with high isotropic resolution, for whole-cell and multicolor imaging.
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An Analysis benchmarks 50 state-of-the-art TCR-epitope binding prediction methods.
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December 11, 2025 at 4:27 PM
An Analysis benchmarks 50 state-of-the-art TCR-epitope binding prediction methods.
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Introducing mScarlet3-S2: a highly photostable and bright red fluorescent protein.
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December 4, 2025 at 8:19 PM
Introducing mScarlet3-S2: a highly photostable and bright red fluorescent protein.
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This Resource provides a multi-omic tissue atlas of aging in nonhuman primates.
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December 3, 2025 at 3:31 PM
This Resource provides a multi-omic tissue atlas of aging in nonhuman primates.
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Our November issue is now live! 🎉
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On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
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On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
November 13, 2025 at 8:38 PM
Our November issue is now live! 🎉
www.nature.com/nmeth/volume...
On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
www.nature.com/nmeth/volume...
On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
High-resolution imaging mass cytometry enables highly multiplexed imaging of nuclear foci and mitochondrial networks.
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October 30, 2025 at 3:41 PM
High-resolution imaging mass cytometry enables highly multiplexed imaging of nuclear foci and mitochondrial networks.
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Our latest Creature Column features the gray mouse lemur, a model for primate brain evolution, cognition, aging and neurodegenerative diseases.
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October 14, 2025 at 5:49 PM
Our latest Creature Column features the gray mouse lemur, a model for primate brain evolution, cognition, aging and neurodegenerative diseases.
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Our October issue is live! 🥳
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On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
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On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
October 10, 2025 at 2:07 PM
Our October issue is live! 🥳
www.nature.com/nmeth/volume...
On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
www.nature.com/nmeth/volume...
On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
Laser ablation of imaged surface layers under adaptive control enables volumetric imaging of heterogeneous tissue like skull and brain.
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October 3, 2025 at 1:31 PM
Laser ablation of imaged surface layers under adaptive control enables volumetric imaging of heterogeneous tissue like skull and brain.
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We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
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September 19, 2025 at 2:54 PM
We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
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A new Perspective discusses the challenges of sharing annotated image datasets and offers advice for improving bioimage annotation and reuse, particularly for AI applications.
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September 17, 2025 at 2:56 PM
A new Perspective discusses the challenges of sharing annotated image datasets and offers advice for improving bioimage annotation and reuse, particularly for AI applications.
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CLEM-Reg automates the 3D alignment of volume correlative light and electron microscopy data.
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September 11, 2025 at 2:25 PM
CLEM-Reg automates the 3D alignment of volume correlative light and electron microscopy data.
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