Nature Nanotechnology
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A journal that covers all aspects of nanoscale science and technology. 🌐 https://www.nature.com/nnano/ 📍Berlin, London and Shanghai. Part of Nature Portfolio.
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New perspective:
Convergence of nanotechnology and CRISPR-based diagnostics.

Authors explore the synergy between CRISPR-based diagnostics and nanomaterials, highlighting opportunities to enhance their development and application.

#CRISPR
#Nanosensors
#Biosensing

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Convergence of nanotechnology and CRISPR-based diagnostics - Nature Nanotechnology
This Perspective examines the technological landscape to bridge the gaps between CRISPR-based diagnostics and nanomaterials, proposing specific synergies that could catalyse their development and application.
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Reposted by Nature Nanotechnology
Reposted by Nature Nanotechnology
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News & Views:

Setting a direction for molecular recognition.

"Directed flow through configurational changes enhancing the specificity of molecular recognition beyond equilibrium conditions has now been demonstrated in a minimal, synthetic, DNA-based system."

www.nature.com/articles/s41...
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News and Views:

The role of polariton lifetime in modifying photochemistry.

"Controlling photochemical charge transfer with polaritons requires optical resonators with a longer lifetime than the reaction itself."

#Polaritons
#Photochemistry

www.nature.com/articles/s41...
The role of polariton lifetime in modifying photochemistry - Nature Nanotechnology
Controlling photochemical charge transfer with polaritons requires optical resonators with a longer lifetime than the reaction itself.
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Now online: September 2025 issue covers

- Nanoneedle biopsy,
- Retinomorphic photodiodes,
- Chiral emission in photonic crystal,
- Nanoporous carbon electrodes,
- Stabilizing photocatalysts for H2 production,
- Endosomal escape of LNP & more.

www.nature.com/nnano/volume...

#Nanotechnology
Nanoneedle arrays classify disease states
The cover image illustrates a nanoneedle chip applied to live brain tissue to sample biomolecules for spatiotemporal lipidomics.

Original article: Gu, C., et al. Nanoneedles enable spatiotemporal lipidomics of living tissues. Nat. Nanotechnol. 20, 1262–1272 (2025). https://doi.org/10.1038/s41565-025-01955-8

Image: Ziqi Zhang (Seamless Design Shanghai) and Ciro Chiappini (King’s College London). Cover design: Vanitha Selvarajan

Abstract
Spatial biology provides high-content diagnostic information by mapping the molecular composition of tissues. However, traditional spatial biology approaches typically require non-living samples, limiting temporal analysis. Here, to address this limitation, we present a workflow using porous silicon nanoneedles to repeatedly collect biomolecules from live brain tissues and map lipid distribution through desorption electrospray ionization mass spectrometry imaging. This method preserves the integrity of the original tissue while replicating its spatial molecular profile on the nanoneedle substrate, accurately reflecting lipid distribution and tissue morphology. Machine learning analysis of 23 human glioma biopsies demonstrated that nanoneedle sampling enables the precise classification of disease states. Furthermore, a spatiotemporal analysis of mouse gliomas treated with temozolomide revealed time- and treatment-dependent variations in lipid composition. Our approach enables non-destructive spatiotemporal lipidomics, advancing molecular diagnostics for precision medicine.