Nature Reviews Cardiology, Published online: 06 October 2025; doi:10.1038/s41569-025-01220-4In this Review, Nicholas Chew and colleagues use epidemiological data on the cardiovascular–liver–metabolic disease syndemic to illustrate current and future projections on the burden of these diseases and their risk factors, and propose a unified framework for integrating and implementing effective multisystem interventions to tackle key components of this syndemic.

Nature Reviews Cardiology, Published online: 02 October 2025; doi:10.1038/s41569-025-01211-5In this Review, Omerovic and Redfors discuss the historical background, clinical presentation and current best practices for the diagnosis and management of Takotsubo syndrome. They also summarize the current understanding of the complex pathophysiology of Takotsubo syndrome, highlighting ongoing and potential future research directions.

Nature Reviews Cardiology, Published online: 01 October 2025; doi:10.1038/s41569-025-01212-4In this Review, Paterson and colleagues describe how bioelectronic approaches involving site-specific targeting of the autonomic nervous circuit could be used to treat cardiovascular disease, and reflect on current bioelectronic modalities, their limitations and future ways to improve therapeutic efficiency.

Nature Reviews Cardiology, Published online: 23 September 2025; doi:10.1038/s41569-025-01221-3In the mouse ischaemic myocardium, neutrophils promote ventricular tachycardia via the secretion of resistin-like molecule-γ, according to a new study published in Science.

Nature Reviews Cardiology, Published online: 18 September 2025; doi:10.1038/s41569-025-01219-xLarge-scale clinical trials presented at the ESC Congress 2025 support the use of high-dose vaccination for influenza to reduce hospitalization for cardiorespiratory disease in older adults and to improve outcomes in patients who have been hospitalized for acute heart failure.

Nature Reviews Cardiology, Published online: 18 September 2025; doi:10.1038/s41569-025-01188-1In this Roadmap, Aggarwal and colleagues summarize current research and knowledge gaps on the relationship between sleep, circadian rhythms and cardiovascular resilience; highlight potential therapeutic targets and interventions for optimizing sleep and circadian rhythms to improve cardiovascular function and prevent disease; and outline research directions and opportunities, emphasizing the need for multidisciplinary collaboration.

Nature Reviews Cardiology, Published online: 15 September 2025; doi:10.1038/s41569-025-01210-6In the dynamic landscape of academic medicine, there is an increased interest in refining the traditional mentoring paradigm to address the many unmet challenges associated with gender disparities within academia. We highlight the need to expand the focus of mentorship to include sponsorship and advocacy, and hope that this shift will foster holistic development in mentees.

Nature Reviews Cardiology, Published online: 15 September 2025; doi:10.1038/s41569-025-01195-2Arrhythmia-induced cardiomyopathy (AIC) refers to heart failure caused or exacerbated by arrhythmias, which resolves completely after restoration of sinus rhythm. In this Review, Fabritz and colleagues focus on atrial fibrillation as the cause of AIC, describing its pathophysiology, epidemiology and clinical presentation, and the various approaches to the diagnostic–therapeutic strategy of rhythm restoration.

Nature Reviews Cardiology, Published online: 12 September 2025; doi:10.1038/s41569-025-01218-yTwo late-breaking clinical trials presented at the ESC Congress 2025 have explored the efficacy of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy.

Nature Reviews Cardiology, Published online: 12 September 2025; doi:10.1038/s41569-025-01209-zIn this Review, Khoury and colleagues examine the growing body of evidence demonstrating the benefits of screening for cardiovascular risk factors, including dyslipidaemia and high blood pressure, starting in childhood to reduce the lifetime burden of cardiovascular disease.

Nature Reviews Cardiology, Published online: 11 September 2025; doi:10.1038/s41569-025-01217-zIn the DIGIT-HF trial, treatment with digitoxin in addition to guideline-directed medical therapy reduced the risk of hospitalization for worsening heart failure or all-cause death compared with placebo in patients with heart failure with reduced ejection fraction.

Nature Reviews Cardiology, Published online: 10 September 2025; doi:10.1038/s41569-025-01216-0In patients with uncontrolled or resistant hypertension, the addition of the aldosterone synthase inhibitor baxdrostat to background antihypertensive therapy reduces seated in-office systolic blood pressure after 12 weeks of treatment, according to findings from the BaxHTN trial presented at the ESC Congress 2025.

Nature Reviews Cardiology, Published online: 09 September 2025; doi:10.1038/s41569-025-01214-2A home-based model of hypertension care can lower blood pressure in patients with hypertension compared with standard care in the clinic, according to the IMPACT-BP trial, which was performed in a rural setting in South Africa and presented at the ESC Congress 2025.

Nature Reviews Cardiology, Published online: 09 September 2025; doi:10.1038/s41569-025-01215-1Routine screening for Helicobacter pylori infection during hospitalization for myocardial infarction does not reduce the risk of upper gastrointestinal bleeding, according to findings from the HELP-MI SWEDEHEART trial, although secondary and subgroup analyses suggest potential clinically meaningful benefits.

Nature Reviews Cardiology, Published online: 08 September 2025; doi:10.1038/s41569-025-01213-3Jorge Peña Peña highlights the 1888 publication from Santiago Ramón y Cajal that provided the first description of the cardiomyocyte sarcolemma.

Nature Reviews Cardiology, Published online: 05 September 2025; doi:10.1038/s41569-025-01205-3In this Review, Porrello and colleagues describe the origins of the fetal gene hypothesis and discuss the evolution of this hypothesis by considering more recent evidence from genome-wide sequencing studies.

Nature Reviews Cardiology, Published online: 02 September 2025; doi:10.1038/s41569-025-01208-0In this Tools of the Trade article, Giles and Meikle describe the development of the the Australian Cardiovascular disease Data Commons, which provides a comprehensive, secure, scalable and internationally integrated database containing pooled data from approximately 400,000 individuals in Australia.

Nature Reviews Cardiology, Published online: 01 September 2025; doi:10.1038/s41569-025-01201-7In this Review, Roden and co-workers describe how multiplexed assays of variant effects can be used for high-throughput functional assessment of nearly all coding variants in a target sequence to improve variant annotation for cardiovascular-related genes and to resolve the problem of classification as variants of uncertain significance. They also discuss how variant effect predictors can be integrated with multiplexed methods to inform cardiovascular genomic medicine.

Nature Reviews Cardiology, Published online: 01 September 2025; doi:10.1038/s41569-025-01207-1Investigators of a new study published in Cell have engineered a new peptide modulator that binds to sodium channels to inhibit the late sodium current, which was shown to reverse the effects of sodium channel dysfunction associated with cardiac arrhythmias and epilepsy.

Nature Reviews Cardiology, Published online: 26 August 2025; doi:10.1038/s41569-025-01206-2Lu Yang and Abha Shrestha revisit the first large-scale trial to investigate the effects of telemonitoring on heart failure outcomes and link the lessons learned from the trial to current digital health strategies and challenges.

Nature Reviews Cardiology, Published online: 15 August 2025; doi:10.1038/s41569-025-01202-6Difficulties, whether arising from work, academic or family environments, are a part of our life. A crucial part of our lives is our response to crisis and how we achieve resilience. In this sense, it is very important to try to turn negative experiences into positive — or at least constructive — experiences. In this Comment, I discuss how to achieve resilience in difficult times.

Nature Reviews Cardiology, Published online: 14 August 2025; doi:10.1038/s41569-025-01204-4Artificial intelligence (AI) technologies are revolutionizing cardiovascular health by analysing environmental factors at an unprecedented scale. Geospatial AI integrates vast datasets — from satellite imagery down to street-level views — to identify complex risk patterns, which enables personalized predictions and guides precision interventions to mitigate the environmental burden of disease.

Nature Reviews Cardiology, Published online: 14 August 2025; doi:10.1038/s41569-025-01192-5The latest developments in the field of hypertension have led to a better understanding of the pathophysiology of hypertension as well as to new pharmacological and device-based therapies and a wealth of clinical guidelines on prevention, diagnosis and treatment. To truly tackle the global epidemic of hypertension, we need a combination of pragmatic approaches and novel precision-medicine-based concepts.