Most Parkinson’s disease research has focused on European and Asian populations, leaving gaps in understanding the disease in other groups. To help address

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01142-2This Perspective centres on alterations in the fatty acid-ome as the critical feature of lipid aberration in α-synucleinopathies, specifically Parkinson disease. Here, the authors explain the biological and genetic basis for their hypothesis, with an emphasis on the transient binding of α-synuclein to fatty acids of various lipids.

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01149-9A new meta-analysis presented at the 2025 American Neurological Association Annual Meeting shows that initiation of hormone replacement therapy in women soon after the onset of menopause is associated with a reduced risk of Alzheimer disease.

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01150-2A new study presented at the 2025 American Neurological Association Annual Meeting indicates that area postrema syndrome in people with neuromyelitis optica spectrum disorder is related to elevated levels of the gut hormone glucagon-like peptide 1 and its receptor GLP-1R.

Nature Reviews Neurology, Published online: 07 October 2025; doi:10.1038/s41582-025-01157-9Autologous haematopoietic stem cell transplantation (AHSCT) offers effective therapy for people with multiple sclerosis (MS), according to new real-world data.

Nature Reviews Neurology, Published online: 07 October 2025; doi:10.1038/s41582-025-01156-wGlioblastomas can shift glucose metabolism from tricarboxylic acid cycle (TCA) oxidation and neurotransmitter synthesis to growth-promoting pathways, according to new research published in Nature.

INTRODUCTION Obesity is a major modifiable risk factor for Alzheimer's disease (AD), but the mechanistic link between peripheral metabolic dysfunction and AD progression remains unclear. Adipose-der...

This study shows an association between premortem peri-ictal apnoea and increased SUDEP risk. Cardiorespiratory monitoring during seizures might benefit assessments of epilepsy mortality risk. Togethe...

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01150-2A new study presented at the 2025 American Neurological Association Annual Meeting indicates that area postrema syndrome in people with neuromyelitis optica spectrum disorder is related to elevated levels of the gut hormone glucagon-like peptide 1 and its receptor GLP-1R.

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01149-9A new meta-analysis presented at the 2025 American Neurological Association Annual Meeting shows that initiation of hormone replacement therapy in women soon after the onset of menopause is associated with a reduced risk of Alzheimer disease.

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01142-2This Perspective centres on alterations in the fatty acid-ome as the critical feature of lipid aberration in α-synucleinopathies, specifically Parkinson disease. Here, the authors explain the biological and genetic basis for their hypothesis, with an emphasis on the transient binding of α-synuclein to fatty acids of various lipids.

SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01150-2A new study presented at the 2025 American Neurological Association Annual Meeting indicates that area postrema syndrome in people with neuromyelitis optica spectrum disorder is related to elevated levels of the gut hormone glucagon-like peptide 1 and its receptor GLP-1R.

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01149-9A new meta-analysis presented at the 2025 American Neurological Association Annual Meeting shows that initiation of hormone replacement therapy in women soon after the onset of menopause is associated with a reduced risk of Alzheimer disease.

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01142-2This Perspective centres on alterations in the fatty acid-ome as the critical feature of lipid aberration in α-synucleinopathies, specifically Parkinson disease. Here, the authors explain the biological and genetic basis for their hypothesis, with an emphasis on the transient binding of α-synuclein to fatty acids of various lipids.

Individuals with schizophrenia show reduced structural similarity in temporal, cingulate, and insular lobes, especially those with worse cognition and symptoms, affecting late maturing association areas with low metabolism and high neurotransmission.

This study assesses whether menopause modifies the risk of disability progression for women with relapse-onset multiple sclerosis.

Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is.....

Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare, multisystem, progressive, debilitating, and fatal disease characterized by tissue deposition of misfolded transthyreti...

Molecular Psychiatry - Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

By investigating temporal changes in glial activation in a slowly progressive in vivo model of ALS, Fioretti et al. show that astrocytes undergo a de-diffe

Nature Reviews Neurology, Published online: 22 September 2025; doi:10.1038/s41582-025-01136-0Many autoimmune and genetic causes of sporadic late-onset cerebellar ataxia (SLOCA) can now be identified, but some individuals remain categorized as having idiopathic SLOCA. Wirth and colleagues discuss advanced genomic techniques that might identify additional ‘missing’ SLOCA causes, potential prognostic biomarkers and progress towards effective treatments.

Nature Reviews Neurology, Published online: 22 September 2025; doi:10.1038/s41582-025-01139-xMyotonic dystrophy type 1 (DM1) is the most prevalent muscular dystrophy in adulthood and among the most clinically diverse monogenic diseases. This Review summarizes the latest insights into the molecular underpinnings of DM1, highlighting the implications for therapy development.