Nature Reviews Rheumatology, Published online: 03 October 2025; doi:10.1038/s41584-025-01305-xThis Perspective article discusses the stratification of patients with knee osteoarthritis (OA) in the context of current guidelines, biomarkers and emerging and future developments of targeted treatment. The authors aim to highlight how these novel developments can enhance the stratification of patients with knee OA to improve patient outcomes.

Nature Reviews Rheumatology, Published online: 02 October 2025; doi:10.1038/s41584-025-01315-9Findings demonstrate that STING mediates necroptosis in the context of autoinflammatory disease, and suggest a potential therapeutic approach.

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01312-yAlthough DADA2 is typically described as an autosomal recessive disease, it can also present in individuals who are heterozygous for specific ADA2 variants.

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01313-xInfused lipid nanoparticles were successfully used to generate CAR-T cells in patients with refractory systemic lupus erythematosus, achieving B cell depletion.

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01303-zThe role of the patient in rheumatology

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01302-0Evidence is emerging that glucagon-like peptide-1 (GLP-1) receptor agonists have anti-inflammatory and chondroprotective properties independent of their effects on weight loss. In this Review, the authors discuss the potential effects of GLP-1 receptor agonists on the incidence, disease activity and progression of various forms of arthritis, as well as practical considerations for their use in this context.

Nature Reviews Rheumatology, Published online: 29 September 2025; doi:10.1038/s41584-025-01308-8Both rheumatology and the publishing environment have seen tremendous changes over the past two decades. Here, the first Editor in-Chief reflects on the challenges faced by this journal and what it has taken to remain at the forefront of the field.

Nature Reviews Rheumatology, Published online: 03 October 2025; doi:10.1038/s41584-025-01305-xThis Perspective article discusses the stratification of patients with knee osteoarthritis (OA) in the context of current guidelines, biomarkers and emerging and future developments of targeted treatment. The authors aim to highlight how these novel developments can enhance the stratification of patients with knee OA to improve patient outcomes.

Nature Reviews Rheumatology, Published online: 02 October 2025; doi:10.1038/s41584-025-01315-9Findings demonstrate that STING mediates necroptosis in the context of autoinflammatory disease, and suggest a potential therapeutic approach.

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01312-yAlthough DADA2 is typically described as an autosomal recessive disease, it can also present in individuals who are heterozygous for specific ADA2 variants.

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01313-xInfused lipid nanoparticles were successfully used to generate CAR-T cells in patients with refractory systemic lupus erythematosus, achieving B cell depletion.

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01302-0Evidence is emerging that glucagon-like peptide-1 (GLP-1) receptor agonists have anti-inflammatory and chondroprotective properties independent of their effects on weight loss. In this Review, the authors discuss the potential effects of GLP-1 receptor agonists on the incidence, disease activity and progression of various forms of arthritis, as well as practical considerations for their use in this context.

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01303-zThe role of the patient in rheumatology

Nature Reviews Rheumatology, Published online: 25 September 2025; doi:10.1038/s41584-025-01304-yIn the past two decades the field of hand osteoarthritis (OA) has moved from resignation to action. Despite progress, such as the recognition of the phenotypic heterogeneity of hand OA (including inflammation- and/or metabolic syndrome-associated hand OA) and the standardization of imaging and treatment outcomes, challenges remain in achieving truly disease-modifying therapies.

Nature Reviews Rheumatology, Published online: 29 September 2025; doi:10.1038/s41584-025-01308-8Both rheumatology and the publishing environment have seen tremendous changes over the past two decades. Here, the first Editor in-Chief reflects on the challenges faced by this journal and what it has taken to remain at the forefront of the field.

Nature Reviews Rheumatology, Published online: 23 September 2025; doi:10.1038/s41584-025-01307-9The collective priorities of the rheumatology field represent the lived experience, and therefore diversity of its members. The ‘mould’ of rheumatology, that is, its culture, structures and expectations, was not created for or by women, but women have slowly changed this mould to make space for diverse perspectives.

Nature Reviews Rheumatology, Published online: 25 September 2025; doi:10.1038/s41584-025-01304-yIn the past two decades the field of hand osteoarthritis (OA) has moved from resignation to action. Despite progress, such as the recognition of the phenotypic heterogeneity of hand OA (including inflammation- and/or metabolic syndrome-associated hand OA) and the standardization of imaging and treatment outcomes, challenges remain in achieving truly disease-modifying therapies.

Seronegative rheumatoid arthritis (RA) is often misunderstood and underrecognized, and this leads to delays in diagnosis and treatment. Emerging studies highlight distinct features and unmet needs of seronegative RA, calling for increased awareness of the challenges faced by patients and the need for tailored therapeutic approaches to improve outcomes.

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with high prevalence in Mediterranean populations. Considerable advances in the management of FMF have been made in the past decade, with respect to the use of biologic drugs and understanding colchicine resistance. The 2024 updated FMF management recommendations are timely and reflect these advances.

This Review provides a comprehensive overview of emerging therapies for the treatment of systemic sclerosis. The authors highlight novel therapeutic targets and emphasize the need for precision medicine approaches for the effective treatment of this disease.

In systemic lupus erythematosus (SLE), pain is one of the most commonly reported and debilitating symptoms. The authors of this Review highlight the importance of understanding the mechanisms of pain in SLE and addressing pain and pain-associated symptoms in the management of SLE.

Nature Reviews Rheumatology - This article provides a comprehensive overview of the epidemiology of spondyloarthritis — including axial spondyloarthritis, psoriatic arthritis and peripheral...

This Review summarizes clinical effectiveness, health economics and safety data on the parathyroid hormone receptor agonists teriparatide and abaloparatide, discussing potential strategies and drug combinations to achieve best outcomes in patients with osteoporosis.

Nature Reviews Rheumatology, Published online: 23 September 2025; doi:10.1038/s41584-025-01307-9The collective priorities of the rheumatology field represent the lived experience, and therefore diversity of its members. The ‘mould’ of rheumatology, that is, its culture, structures and expectations, was not created for or by women, but women have slowly changed this mould to make space for diverse perspectives.