Wie lassen sich die Behandlungserwartungen der Patient:innen nutzen, um den Therapieerfolg zu optimieren? Diese Frage diskutiert Laura Weisenburger.

Klinische Studien sind ein zentraler Baustein bei der Entwicklung von neuen Therapien sowie bei der Optimierung bestehender Behandlungsmethoden. Durch die Teilnahme an klinischen Studien können unsere...

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Cell Death & Disease - In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies

Neutrophils are readily activated immune cells after ischemic stroke in mice and patients. Still, the impact of gut microbiota on neutrophil activation and its influence on inflammatory brain injury remain undefined. We report that natural microbiota colonization of germ-free (GF) mice induces substantial neutrophil activation and deteriorates stroke pathology. The colonized Ex-GF stroke mice had considerably larger infarct sizes and higher sensorimotor deficits than GF littermates. Furthermore, employing an antibiotic-based mouse model of microbiota deficiency, we demonstrate that gut microbiota depletion induces a juvenile neutrophil phenotype characterized by the upregulation of resting state surface receptors, reduced inflammatory proteins, and levels of circulating NETs. This disarming of neutrophil responses was associated with decreased expression of brain inflammatory genes, vascular thrombus formation, reduced infarct size, and alleviated behavioral deficits. We conclude that gut microbes strongly influence neutrophil activation after stroke and thus directly contribute to stroke severity.

More than 10 years after unusually high water temperatures in the Pacific Ocean killed off Northern California’s aquatic kelp forests, the region has still not recovered, reports David Helvarg,…