This study presents the first com­prehensive crystallographic characterization of salcaprozoic acid (HNAC), the free acid form of salcaprozate sodium (SNAC), using single-crystal X-ray diffraction. A well-organized hy­dro­gen-bonding framework underpins the robust crystal packing and thermal stability of the com­pound. Complementary IR spectroscopy highlighted the impact of hy­dro­gen bonding on vibrational modes.

This study presents the first com­prehensive crystallographic characterization of salcaprozoic acid (HNAC), the free acid form of salcaprozate sodium (SNAC), using single-crystal X-ray diffraction. A ...

Small molecule inhibitors of lysine deacetylases (KDACs), exemplified by histone deacetylases (HDACs), exhibit significant promise as cancer therapeutics. Using a modular combinatorial chemistry ap...

Understanding the alkaline stability of quaternary ammonium (QA) cations tethered to polymer backbones in anion-exchange membranes (AEMs) is crucial to advance the long-term performance of anion-excha...

C [[double bond, length as m-dash]] O methylenation mediated by α-silyl organo-alkali metal reagents, namely Peterson methylenation, is a textbook organic reaction that has been widely employed in syn...

The global burden of tuberculosis is on the rise and continues to be alarmingly high, with a notable prevalence of multidrug-resistant disease. Despite a promising drug development pipeline, the level...

Students’ overall experience of university life and their assessment outcomes are partly determined by their engagement with teaching activities, which is in turn influenced by their sense of social cohesion with their peers. In addition to providing pastoral support, in our role as Senior Tutors, we encourage the formation of a more cohesive learning community among chemistry students post-COVID. With the aim of building better connections both between us and the new student cohort and between the students themselves, we have introduced new Senior Tutor Check-In sessions, which are built around a new chemical drawing game: CHEMmunicate. Across the first semester, we held 8 sessions with ca. 12–16 new first year chemistry undergraduate students in which two teams competed to draw chemical structures using yes/no questions (total: 200 participants over two separate cohorts). In this paper, we outline the rules of the game and provide tips for session leaders seeking to implement it at other institutions. Moreover, through analysis of student feedback from questionnaires and a focus group, we demonstrate how CHEMmunicate and the Senior Tutor Check-In sessions can prove beneficial in building student cohesion and enhancing students’ learning of organic chemistry.

Crystal structures that form with more than one molecule in the asymmetric unit (Z′ > 1) are a fascinating and important, if overlooked, aspect of crystal engineering. With the recent publication of t...

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Polymorphism, when a substance can exist in more than one crystalline form yet return to the same liquid or solution phase, is characterized by differences in packing or molecular conformation. Polymo...