Nicholas Clifton
@nicl2.bsky.social
81 followers 100 following 1 posts
Researcher in neuroscience and psychiatric genomics, University of Exeter
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nicl2.bsky.social
New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...
Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation
AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1
doi.org