@nilimesh.bsky.social
Postdoc in Boston Children's Hospital & Harvard Medical School
Phd at IIT Kanpur, India
Currently, probing how FUS, SMC-5/6 & DDX6 shape transcription, DNA, and condensates
Phd at IIT Kanpur, India
Currently, probing how FUS, SMC-5/6 & DDX6 shape transcription, DNA, and condensates
Reposted
🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...
Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome
The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. While mechanistic investigations have uncovered many facets of GATA1 biol...
www.biorxiv.org
September 22, 2025 at 2:29 PM
🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...
Reposted
Confocal scanning laser microscopy, fluorescence lifetime imaging & Raman analyses allowed @nhm-london.bsky.social, @slcuplants.bsky.social & @cambridge-ee.bsky.social researchers to resolve plant & fungal structures fossil
Read in @newphyt.bsky.social
doi.org/10.1111/nph....
@dromius.bsky.social
Read in @newphyt.bsky.social
doi.org/10.1111/nph....
@dromius.bsky.social
November 12, 2025 at 12:31 PM
Confocal scanning laser microscopy, fluorescence lifetime imaging & Raman analyses allowed @nhm-london.bsky.social, @slcuplants.bsky.social & @cambridge-ee.bsky.social researchers to resolve plant & fungal structures fossil
Read in @newphyt.bsky.social
doi.org/10.1111/nph....
@dromius.bsky.social
Read in @newphyt.bsky.social
doi.org/10.1111/nph....
@dromius.bsky.social
Protein aggregation in cells can start at nanomolar levels as tiny clusters that are hard to see with standard methods. This study uses fluorescence correlation spectroscopy to spot and study these invisible early aggregates.
www.growkudos.com/publications...
www.growkudos.com/publications...
Unraveling Protein Clumps: Using Fluorescence to Study Aggregation at the Nano Scale
This study uses advanced fluorescence techniques to track how proteins like bromelain clump together at extremely low concentrations. The authors compare different methods, highlighting how fluorescen...
www.growkudos.com
December 30, 2025 at 8:09 AM
Protein aggregation in cells can start at nanomolar levels as tiny clusters that are hard to see with standard methods. This study uses fluorescence correlation spectroscopy to spot and study these invisible early aggregates.
www.growkudos.com/publications...
www.growkudos.com/publications...
In aged condensates, weaker protein–RNA interactions release RNA from the dense phase. Aging plus slow macromolecular diffusion then tarts nucleatiin, producing double-emulsion.
Formation of multi compartment structures through aging of protein-RNA condensates: www.cell.com/biophysj/ful...
Formation of multi compartment structures through aging of protein-RNA condensates: www.cell.com/biophysj/ful...
Formation of multicompartment structures through aging of protein-RNA condensates
Cells can dynamically organize reactions through the formation of biomolecular condensates.
These viscoelastic networks exhibit complex material properties and mesoscale architectures,
including the a...
www.cell.com
December 28, 2025 at 2:02 AM
In aged condensates, weaker protein–RNA interactions release RNA from the dense phase. Aging plus slow macromolecular diffusion then tarts nucleatiin, producing double-emulsion.
Formation of multi compartment structures through aging of protein-RNA condensates: www.cell.com/biophysj/ful...
Formation of multi compartment structures through aging of protein-RNA condensates: www.cell.com/biophysj/ful...
Cryo-EM snapshots of Wadjet show how ATP fuels a 360° dimer rotation to trap DNA and set the stage for loop extrusion
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
October 31, 2025 at 3:56 PM
Cryo-EM snapshots of Wadjet show how ATP fuels a 360° dimer rotation to trap DNA and set the stage for loop extrusion
You don't need all 20 amino acids to build proteins! Here, authors showed
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
Ancient amino acid sets enable stable protein folds
Early proteins likely arose from a chemically limited set of amino acids available through prebiotic chemistry, raising a central question in molecular evolution: could such primitive compositions yie...
www.biorxiv.org
October 31, 2025 at 6:53 AM
You don't need all 20 amino acids to build proteins! Here, authors showed
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
Reposted
💪 Small but mighty! This JIPB mini-review explores the remarkable dual-action mechanism of #Arabidopsis cryptochromes. PlantScience onlinelibrary.wiley.com/doi/10.1111/...
February 28, 2024 at 1:20 PM
💪 Small but mighty! This JIPB mini-review explores the remarkable dual-action mechanism of #Arabidopsis cryptochromes. PlantScience onlinelibrary.wiley.com/doi/10.1111/...