nishahemandhar.bsky.social
Nisha Hemandhar
@nishahemandhar.bsky.social
45 followers 93 following 14 posts
Postdoctoral researcher @cecad.bsky.social | Budding Molecular Biologist | Freelancer| Interested in #Neuroscience #Proteotranscriptomics #Multiomics #AlternativeSplicing #Aging 🇮🇳 > 🇺🇲 > 🇩🇪📍
Posts Media Videos Starter Packs
Pinned
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.

Co–first author with Verena Kluever. Grateful to @forna.bsky.social‬ for mentorship, and to @tatjanat.bsky.social‬, Carlos López Otín & all collaborators🧠
2 3 8
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Sep 7
Thanks!
1
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Sep 4
I'll be presenting our latest work, that explores proteo-transcriptomic changes that occur with brain aging and their impact on protein synthesis at the #EMBLProtein conference.

If you want to know more about it, come and spin my poster #129.
#proteinsynthesis #brainaging
1 9
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
doi.org/10.1101/2025...
Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain
Brain aging is a major risk for neurodegeneration, yet the underlying molecular mechanisms remain poorly understood. Here we performed an integrative proteo-transcriptomic analysis of the aging mouse ...
doi.org
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
Our study provides an extensive resource on molecular aging, and offers insights into mechanisms predisposing to neurodegeneration, easily accessible at our Brain Aging and Molecular Atlas Project (BrainAging-MAP) website.
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
Analysis of the nine models revealed key similarities and differences between physiological aging and pathology.
1
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
Aggregation of 60S ribosome proteins indicates deteriorating translation efficiency and control. A tightening of the p/m coefficient with age suggests aging reduces regulatory capacity, increasing mRNA–protein correlation.
1 1
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
Decrease in mitochondrial complex I proteins were not compensated at the mRNA level.
1
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
We identified dynamic changes in physiological aging, highlighting differences in synaptic maintenance and energy-allocation.
1
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Aug 20
Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.

Co–first author with Verena Kluever. Grateful to @forna.bsky.social‬ for mentorship, and to @tatjanat.bsky.social‬, Carlos López Otín & all collaborators🧠
2 3 8
Reposted by Nisha Hemandhar
crc1678.bsky.social
CRC1678 @crc1678.bsky.social · Jul 14
Today marks the first day of our very first CRC 1678 Early Career Researcher Retreat! We’re proud to have such an amazing group of scientists with us—full of curiosity, energy, and team spirit. 💥🧠 🥳💪 #CRC1678 #ECRetreat #ScienceCommunity
1 4 10
Reposted by Nisha Hemandhar
rhinelandrna.bsky.social
Rhineland RNA Club @rhinelandrna.bsky.social · Jun 24
We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky
1 6 12
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Apr 29
Thank you!
Reposted by Nisha Hemandhar
forna.bsky.social
Eugenio F. Fornasiero @forna.bsky.social · Apr 22
Excited for our latest work! We developed nanobinders for the luminal domain of Synaptotagmin 1 (calcium sensor for synaptic vesicles). Thanks among others to @verstrekenlab.bsky.social @opazo.bsky.social @meunierlab.bsky.social @volkerhaucke-lab.bsky.social www.biorxiv.org/content/10.1...
Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models.
Synaptic neurotransmission is a critical hallmark of brain activity and one of the first processes to be affected in neural diseases. Monitoring this process, and in particular synaptic vesicle recycl...
www.biorxiv.org
2 19 23
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Mar 28
Congratulations Dr. Shyam!
1
Reposted by Nisha Hemandhar
forna.bsky.social
Eugenio F. Fornasiero @forna.bsky.social · Mar 20
🚀 Thrilled to share our latest research! With the labs of Yansheng Liu and Junmin Peng we’ve built the largest in vivo protein turnover resource across multiple tissues and brain regions, now published in Cell @cellpress.bsky.social 🔬💡 #Proteomics Check it out! 👇
authors.elsevier.com/c/1koBJL7PXu...
6 8
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Feb 10
Thank you!
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Feb 10
Thank you Jan!
nishahemandhar.bsky.social
Nisha Hemandhar @nishahemandhar.bsky.social · Feb 8
If that was the peak of my climb, then every grueling step—each hardship endured—prepared me for an extraordinary destiny!

Thanks to everyone who made this possible, especially @forna.bsky.social for your support and mentorship over the years!
@imprsgs.bsky.social #PhDone
2 8