Novoa Lab joined the PRBB Open Day 2025🔬🧬🌊 @prbb.org to share our passion for RNA research with the public. Thanks to everyone who came to explore science with us and thanks organisers for making this event possible! #PRBBOpenDay #OpenScience

A little lunch selfie to mark our return to bluesky after summer break! 🌱 Exciting projects ahead—stay tuned for updates from the Novoa Lab🤙🏻

Last month, the @novoalab.bsky.social attended the Premis Nacionals de Recerca ceremony to celebrate @evamarianovoa.bsky.social receiving the National Young Researcher Award! 🎉👏
Huge congratulations again, Eva - an incredible and well-deserved recognition! 🧬🏆

🚨 Fresh preprint from Novoa Lab!
Curious about RNA modification-aware basecaller performance?
Dive into the detailed recap by @gdiensthuber.bsky.social and explore the full story here: bit.ly/4lXqNul 🧬🔍

Another epic Novoa Lab retreat in the books!
A big thank you to everyone who made it such a success — from the science-packed discussions and hands-on workshops to the brainstorming, games, sunny pool sessions, and delicious BBQs. And special thanks to the organizers!⚘️
@evamarianovoa.bsky.social

Big thanks to the @crg.eu community and the Novoa lab memebers for all the support and discussions.

Please read us and share your comments! :)

m6ABasecaller can predict m6A modifications at SINGLE MOLECULE resolution and we use it to ask exciting biological questions: we explored the cross-talk between m6A sites within the same read, the interaction between m6A and polyA tail lengths, the m6A differences between isoforms and much more!

You can use the m6ABasecaller on a stand-alone sample, without the need for a WT/KO comparison to identify your sites to call m6A modifications completely de novo in different species (e.g. human, mouse, zebrafish…)

But what’s the big deal with modification basecalling?

Yes, it was developed with RNA002 chemistry, so if you have RNA002 sequencing data you can use m6ABasecaller to identify m6A in individual reads directly during the basecalling process. If you only have RNA004 data, there’s also promising results about it so stay tuned for updates from Novoa lab ;)

Leveraging the tool NanoRMS2 (github.com/novoalab/nan...) we generated labels to train the first modification-aware basecaller for m6A, which we called m6ABasecaller (github.com/novoalab/m6A...).

This was a great collaborative effort co-lead by @soniacruciani.bsky.social, Anna Delgado-Tejedor and Leszek Pryszcz with the help of Rebeca Medina and Laia Llovera and under the supervision of @evamarianovoa.bsky.social

New manuscript from the Novoa lab was published this week in Genome Biology! You can give it a read here: rdcu.be/ebiIs