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NOVOS
@novoslabs.bsky.social
Making the latest scientific advances in longevity accessible and achievable for all. #YoungerForLonger
Resistance-training injuries show clear sex-specific patterns: a 10-year U.S. ED review found sharp rises in shoulder and trunk/lower-back cases, especially from pressing and overhead lifts.
In your gym, do the injuries you see follow these sex-specific trends?
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From the NovosLabs community on Reddit: Resistance training injuries: 10-year U.S. ED trends show sex-specific patterns worth addressing
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December 10, 2025 at 1:02 PM
Detraining after 60 hits fast: blood pressure climbs, triglycerides and glucose go up, HDL drops, and body fat rises even if weight doesn’t. The decline gets sharper after ~3 months (17-studies).
If training had to stop, what would be your top priority to keep stable reddit.com/r/NovosLabs/...
From the NovosLabs community on Reddit: Detraining in older adults: how fast do cardiovascular risk factors worsen after you stop training? (systematic review, N=17 studies)
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December 9, 2025 at 11:39 PM
Even “normal” liver fat wasn’t so normal: in 597 adults, every +1% (MRI) increased the odds of metabolic issues, and risks showed up well below the usual 5.6% cutoff.
If small changes already matter, what’s the one thing you’d adjust starting today?
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From the NovosLabs community on Reddit: Even "normal" liver fat is associated with features of metabolic syndrome (N=597, MRI-PDFF). Do the thresholds need to be updated?
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December 9, 2025 at 2:49 PM
Capacity peaks around 30, then declines accelerate to ~2.0–2.5% per year by the mid-40s in this 47-year Swedish cohort
Which metric are you prioritizing before 40 to counter the early decline?
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From the NovosLabs community on Reddit: 47 years of data: capacity peaks early, declines faster than we think. What’s your plan after 40?
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December 8, 2025 at 2:10 PM
29 human trials: ginger modestly lowers inflammation in the bloodstream, with clearer effects at ~2–3 g/day for 8–12 weeks. How does this change your ginger supplementation routine?
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From the NovosLabs community on Reddit: Ginger supplementation and inflammation: 29-trial dose–response meta-analysis finds modest biomarker improvements
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December 5, 2025 at 5:11 PM
L-theanine cut oxidative stress, stabilized calcium, and dialed down ferroptosis in a diquat muscle-stress model, a surprisingly broad mitochondrial rescue for a simple amino acid.
Does this shift how you think about recovery supplements?
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From the NovosLabs community on Reddit: L-theanine for muscle oxidative stress: preclinical data link mitochondria, Ca²⁺ balance, and ferroptosis inhibition
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December 4, 2025 at 6:14 PM
Ultra-low LDL (<40 mg/dL) after stroke was linked to lower recurrence in 5,291 patients , with no hemorrhage penalty. How would this change your LDL-target thinking for secondary prevention?
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From the NovosLabs community on Reddit: Very low LDL cholesterol (<40 mg/dL) after ischemic stroke: benefits without a hemorrhage penalty
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December 4, 2025 at 2:36 PM
Time-restricted fasting plus NMN boosted mouse endurance and grip in a 6-week study, with mitochondrial and microbiome improvements.
Would you ever combine TRF + NMN in your own training?
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From the NovosLabs community on Reddit: Time-restricted fasting plus NMN: mouse study reports better endurance/strength via mitochondrial and microbiome shifts
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December 3, 2025 at 5:12 PM
Oral hyaluronic acid improved skin hydration and wrinkle scores across 7 human trials, some effects as early as 4 weeks. But heterogeneity is real.
Which endpoint matters most to you: hydration %, wrinkle depth, or elasticity?
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From the NovosLabs community on Reddit: Oral hyaluronic acid for skin: 7-trial meta-analysis finds gains in hydration, elasticity, and wrinkle depth
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December 3, 2025 at 1:24 PM
Vitamin C slowed ovarian aging over 3.3 years in primates fewer senescent cells, more follicles preserved, and ‘younger’ cellular clocks.
If you track reproductive aging, how (and when) would findings like these shape your supplement choices?
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From the NovosLabs community on Reddit: Vitamin C and ovarian aging: 3.3-year primate study reports slowed cellular clocks and preserved follicles
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December 2, 2025 at 3:37 PM
Rhodiola rosea boosts VO₂max and time-to-exhaustion in 26 trials (N=668), though most evidence comes from short-term studies.
Are these results enough for you to add Rhodiola to your endurance stack?
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From the NovosLabs community on Reddit: Rhodiola rosea and endurance: 26-trial meta-analysis reports small but significant gains (VO₂max, time-to-exhaustion)
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December 1, 2025 at 4:38 PM
Magnesium improved insomnia scores in small RCTs (320–500 mg for 7–8 weeks), but overall sleep evidence is still modest.
Have you ever noticed a clear difference in your deep sleep or HRV with magnesium?
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From the NovosLabs community on Reddit: Does magnesium actually improve sleep? A 2025 narrative review maps mechanisms and human evidence
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December 1, 2025 at 2:38 PM
Curious about “red spinach” nitrate supplements? A 2025 safety review found them safe within the tested ranges, and one trial even reported ~19% longer time-to-exhaustion.
Have you tried nitrate supplements yourself, and did you notice any difference?
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From the NovosLabs community on Reddit: Red spinach nitrate safety for athletes: 2025 review finds short-term use safe, performance effects mixed
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November 28, 2025 at 5:59 PM
UK Biobank accelerometer data suggest that getting most of your daily steps in one longer continuous walk is linked to lower CVD and mortality risk compared with the same steps scattered throughout the day.
If you had 40 minutes, would you take them in one go?
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November 27, 2025 at 3:38 PM
New AHA statement: circadian health matters, timing and regularity of sleep, light, meals, and exercise all link to cardiometabolic risk.
What one timing change would you test first?
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From the NovosLabs community on Reddit: New AHA statement: circadian health and cardiometabolic risk—time your light, meals, and exercise
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November 26, 2025 at 1:31 PM
How low should LDL (bad cholesterol) go?
Clinical trials where people reached very low LDL levels around 20–40 mg/dL kept showing fewer cardiovascular events, with no clear safety issues.
Given your own baseline risk, what do you think your target LDL should be?
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From the NovosLabs community on Reddit: How Low Should LDL Cholesterol Go? 2025 Review Supports Targets <55 mg/dL—and Even ~20 mg/dL—in High-Risk Adults
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November 25, 2025 at 3:49 PM
7,000 steps/day provides roughly the same mortality benefit as 10,000, with the largest gains around 8–9k, according to large observational cohorts (Lancet Public Health).
On busy days, would you settle for 7k or still push for 10k?
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From the NovosLabs community on Reddit: 7,000 daily steps as good as 10,000? Lancet Public Health meta-analysis pinpoints the practical threshold for risk reduction
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November 24, 2025 at 8:03 PM
Post-exercise hot bathing at 40 °C increased strength gains compared with training alone in a small, short, unblinded RCT.
Would you add a 15–20 min soak after heavy sets?
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From the NovosLabs community on Reddit: Post-exercise hot bathing (40 °C) boosted strength gains
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November 24, 2025 at 1:38 PM
Strong evidence that it’s never too late to begin!
Starting exercise at 50–70 is associated with lower mortality compared with remaining inactive, based on large observational cohorts.
Which first 2–3 weekly sessions would you choose to kick off your routine?
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November 21, 2025 at 1:39 PM
Sleep regularity matters: Observational data show that people whose sleep timing swings by ±60 minutes tend to have worse metabolic health and mood.
How steady is your sleep, within 30 minutes, or more than an hour?
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From the NovosLabs community on Reddit: The 4th Pillar of Sleep Health: Sleep Regularity
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November 20, 2025 at 5:05 PM
Practical protein targets: Consume 1.2–1.6 g of protein per kg of body weight per day, with ~2–3 g of leucine per meal across 3–4 meals, suitable for vegan, vegetarian, or omnivorous diets.
How do you hit your per-meal protein or leucine targets, any tips or tricks?
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From the NovosLabs community on Reddit: Optimal protein ratio for vegan, vegetarian, and pesco meals: new model suggests simple % targets for protein quality and key minerals
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November 20, 2025 at 12:48 PM
Flavan-3-ol intake of 400–600 mg/day is linked to modest reductions in blood pressure and improvements in lipid profiles.Evidence comes from both RCTs and observational studies.
What’s your preferred source of flavan-3-ols?
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November 19, 2025 at 1:58 PM
Life’s Essential 8 (LE8) score flags near- and long-term risk: better LE8 = fewer events and slower aging signals.
If you tracked LE8, which component would you work on first?
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November 18, 2025 at 4:30 PM
Would you trust a blood RNA senescence score over your methylation clock?
A recent observational study found that a blood RNA senescence score closely tracks biological age in humans, though it still requires external validation.
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Blood RNA “senescence scores” predict biological age, multimorbidity, cognition, and 6-year mortality in a U.S.-representative cohort
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November 18, 2025 at 12:55 PM
New review: does building muscle improve insulin sensitivity and lipid profiles even without weight loss?
If you did an 8–12 week muscle-building phase, what actually changed for you ? fasting insulin, fasting glucose, long-term blood sugar (HbA1c), or triglycerides?
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From the NovosLabs community on Reddit: Muscle hypertrophy and metabolic health: new review quantifies fat loss and HbA1c drops linked to small gains in muscle mass
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November 17, 2025 at 4:14 PM