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Carvone derived cannabidiol enantiomers as novel anticonvulsants - Neuropsychopharmacology

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Screening carvone-derived (+)-CBD enantiomers found that longer alkyl chains ⬆️ anticonvulsant potency, with (+)-CBD-oct ⬇️ seizures, mortality & abnormal dendritic spines in 🐭, highlighting alkyl chain length as a key determinant of efficacy in next-gen CBD analogs for epilepsy

Neuropsychopharmacology - Carvone derived cannabidiol enantiomers as novel anticonvulsants

Moving from isolation to integration: a Bayesian multisensory perspective of interoception and psychosis - Neuropsychopharmacology

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This ✨ Early Career Commentary ✨ argues that interoception - the sensing & interpretation of internal bodily signals - should be studied within a Bayesian multisensory framework, since internal sensations are constantly integrated with external & proprioceptive inputs 🧠✋

Neuropsychopharmacology - Moving from isolation to integration: a Bayesian multisensory perspective of interoception and psychosis

Namesake of PF-05231023: how nomenclature confusion leads to experimental misinterpretation in pharmacologic research - Neuropsychopharmacology

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Acknowledging the compound used in their study, purchased as FGF21 receptor agonist PF-05231023, was misidentified (NMR analysis revealed it was Maleide-PEG2-AZD), the authors are conducting further investigations to clarify earlier reported findings

www.nature.com/articles/s41...

Neuropsychopharmacology - Namesake of PF-05231023: how nomenclature confusion leads to experimental misinterpretation in pharmacologic research

Change in brain molecular landscapes following electrical stimulation of the nucleus accumbens - Neuropsychopharmacology

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NAc deep brain stimulation (DBS) altered genes linked to synaptic plasticity, stress, & inflammatory signaling - particularly in glutamatergic neurons expressing Nlgn1, Snca, Pde10a, & Syt1 - revealing molecular mechanisms through which NAc DBS may modulate 🧠 circuits

Neuropsychopharmacology - Change in brain molecular landscapes following electrical stimulation of the nucleus accumbens

Clozapine induces perineuronal net remodeling in a developmental mouse model exhibiting schizophrenia-relevant phenotypes - Neuropsychopharmacology

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Perinatal NMDA receptor hypofunction ⬆️ perineuronal net thickness and rigidity, disrupted excitation–inhibition balance, & impaired cognition & social memory, which was partially restored by clozapine 💊

www.nature.com/articles/s41...

Neuropsychopharmacology - Clozapine induces perineuronal net remodeling in a developmental mouse model exhibiting schizophrenia-relevant phenotypes

Acute effects of MDMA, MDA, lysine-MDMA, and lysine-MDA in a randomized, double-blind, placebo-controlled, crossover trial in healthy participants - Neuropsychopharmacology

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In healthy humans, MDMA metabolite MDA produced longer & stronger psychedelic-like effects than MDMA, along with ⬆️ negative & fear-related responses 😱

Lys-MDA acted as a slow-release MDA, delaying onset & peak effects, while Lys-MDMA failed to release MDMA 💊

Neuropsychopharmacology - Acute effects of MDMA, MDA, lysine-MDMA, and lysine-MDA in a randomized, double-blind, placebo-controlled, crossover trial in healthy participants

Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound - Neuropsychopharmacology

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Low-intensity focused ultrasound disrupted functional connectivity along targeted tracts, ⬆️ positive affect, & ⬇️ cardiac-sympathovagal balance in patients w/ MDD, offering a potential tool for probing & treating mood-related🧠 networks

www.nature.com/articles/s41...

Neuropsychopharmacology - Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound

Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice - Neuropsychopharmacology

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RNAscope mapping showed limited CB1R–MOR co-expression, mainly in thalamic glutamatergic neurons, suggesting that cannabinoid–opioid synergy arises from parallel activation in distinct circuits rather than direct receptor interaction

www.nature.com/articles/s41...

Neuropsychopharmacology - Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice

Concerted elevations of cortical and striatal glutamate and GABA in antipsychotic-free individuals at clinical high-risk for psychosis - Neuropsychopharmacology

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Glutamate (Glx) & GABA were ⬆️ in antipsychotic-free individuals at clinical high risk for psychosis compared with healthy controls, showing that medication status critically influences MRS-based neurochemical results in psychosis research

www.nature.com/articles/s41...

Neuropsychopharmacology - Concerted elevations of cortical and striatal glutamate and GABA in antipsychotic-free individuals at clinical high-risk for psychosis

There is still so much work to be done: a mother’s perspective - Neuropsychopharmacology

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A mother recounts her son’s prolonged struggle with severe childhood mental illness, marked by shifting diagnoses/medications & persisting symptoms, despite expert care; she calls for more rigor in diagnosing & treating pediatric mental illness

www.nature.com/articles/s41...

Neuropsychopharmacology - There is still so much work to be done: a mother’s perspective

Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories - Neuropsychopharmacology

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This 🔥 Hot Topic 🔥 highlights how 🧠 bioenergetics (e.g., the regulation of energy metabolism & mitochondrial function) drive psychiatric vulnerability, highlighting metabolic interventions that may ⬆️ energetic balance & support 🧠 development

www.nature.com/articles/s41...

Neuropsychopharmacology - Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories

A review of the impact of structural racism on lived experiences of adolescents of African descent: Implications for development, brain structure, and health - Neuropsychopharmacology

Neuropsychopharmacology @npp-journal.bsky.social · 1d

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This 🔃 Review 🔃 examines how structural racism is embedded in nearly every sector of society, creating social & environmental contextual drivers that affect mental & physical health of minoritized populations

www.nature.com/articles/s41...

Neuropsychopharmacology - A review of the impact of structural racism on lived experiences of adolescents of African descent: Implications for development, brain structure, and health

Building brain resilience through brain capital - Neuropsychopharmacology

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This 🔥 Hot Topic 🔥 introduces Building Brain Resilience through Brain Capital - an emerging concept that cuts across sectors & holds the promise of transforming the way we treat mental illnesses 🧠

www.nature.com/articles/s41...

Neuropsychopharmacology - Building brain resilience through brain capital

Role of molecularly defined lateral septum cell types and circuits in social behaviors - Neuropsychopharmacology

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This 🔥 Hot Topic 🔥 highlights new insights into how the lateral septum regulates social behavior via the amygdala & PFC

Cross-species molecular studies suggest conserved mechanisms that may underlie social dysfunction in psychiatric disorders

www.nature.com/articles/s41...

Neuropsychopharmacology - Role of molecularly defined lateral septum cell types and circuits in social behaviors

In Memoriam: Terry A. Ketter, MD - Neuropsychopharmacology

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Terry A. Ketter, M.D., Fellow of @acnporg.bsky.social passed away on November 1, 2024

www.nature.com/articles/s41...

Neuropsychopharmacology - In Memoriam: Terry A. Ketter, MD

Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function - Neuropsychopharmacology

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Impaired astrocyte function biases action toward excessive goal-directed responding, suggesting striatal neuroinflammation may promote maladaptive goal-directed behaviors, challenging the view that compulsivity arises solely from habit dominance / @bradfield-neuro.bsky.social

Neuropsychopharmacology - Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function

Digital frontlines: leveraging AI to augment human expertise in crisis and combat situations - Neuropsychopharmacology

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This 🔥 Hot Topic 🔥 discusses how AI-assisted decision-support systems, including large language models, could strengthen mental health care in conflict zones by supporting clinician reasoning & consistency under extreme stress

www.nature.com/articles/s41...

Neuropsychopharmacology - Digital frontlines: leveraging AI to augment human expertise in crisis and combat situations

From symptom-based heterogeneity to mechanism-based profiling in youth ADHD: the promise of computational psychiatry - Neuropsychopharmacology

Neuropsychopharmacology @npp-journal.bsky.social · 1d

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This 🔃 Review🔃 discusses how computational psychiatry can reveal latent mechanisms in ADHD & mood disorders, emphasizing ways to ⬆️ reliability & develop more precise, ecologically valid models for diagnosis & treatment / @nadjagingjehli.bsky.social

www.nature.com/articles/s41...

Neuropsychopharmacology - From symptom-based heterogeneity to mechanism-based profiling in youth ADHD: the promise of computational psychiatry

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Neuropsychopharmacology @npp-journal.bsky.social · 1d

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Neuropsychopharmacology @npp-journal.bsky.social · 1d

#ThisWeekInNPP

Neuropsychopharmacology @npp-journal.bsky.social · 1d

#ThisWeekInNPP