@nrajkanwar.bsky.social
Reposted
Thrilled to share our recent work describing an ancient coupling between protein quality control and redox-signaling through leveraging the tunability of Zn(II) binding by editing domains of two universally conserved aa-tRNA synthetases.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A metal ion mediated functional dichotomy encodes plasticity during translation quality control - Nature Communications
The editing domains of AlaRS (AlaRS-Ed) and ThrRS (ThrRS-Ed) are homologous, yet they differ in sensitivity to reactive oxygen species (ROS). Here, the authors reveal the mechanistic basis of how the ...
www.nature.com
April 17, 2025 at 3:42 PM
Thrilled to share our recent work describing an ancient coupling between protein quality control and redox-signaling through leveraging the tunability of Zn(II) binding by editing domains of two universally conserved aa-tRNA synthetases.
www.nature.com/articles/s41...
www.nature.com/articles/s41...