Valentine Svensson
@nxn.se
Molecular cell biology and stats / ML, mostly scRNA-seq.
Principal Scientist at Tahoe Tx.
https://www.nxn.se/archive
Principal Scientist at Tahoe Tx.
https://www.nxn.se/archive
Technically DESeq2 is a hierarchical model, but only does two levels (treatment effects partially pool genes). I've used standard multilevel modeling packages for pseudobulks in hierarchical designs at times. They write in the paper that situation may differ for few non-zero effects like gene expr.
January 23, 2026 at 6:27 AM
Technically DESeq2 is a hierarchical model, but only does two levels (treatment effects partially pool genes). I've used standard multilevel modeling packages for pseudobulks in hierarchical designs at times. They write in the paper that situation may differ for few non-zero effects like gene expr.
Self-aware autocorrelation
January 15, 2026 at 8:26 AM
Self-aware autocorrelation