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NYU Pain Research Center @nyupainresearch.bsky.social · 5d

@karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @sdavidson.bsky.social @mariafialho.bsky.social @tonelloraquel.bsky.social @rbruni2.bsky.social

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NYU Pain Research Center @nyupainresearch.bsky.social · 5d

Huge thanks to "3-Minute Mondays!" for this fantastic feature! Don't forget to subscribe @nyudentistry on #YouTube.... To learn more about the #NYU #PainResearchCenter. Click below to dive in! www.youtube.com/watch?v=naoQ... #YouTube #NYUDentistryoutubechannel #PainResearchCenter

"3-Minute Mondays!": NYU Pain Research Center

YouTube video by NYUDentistry

www.youtube.com

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

Big congratulations to postdoc Sarah Najjar from the Margolis Lab on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

🎉 Congrats to Dr. Moayedi on receiving the Whitehead Fellowship! This project explores how sensory feedback from upper airway muscles supports voicing—unlocking neural pathways with big implications for treating airway disorders. 👏🧠💬

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

The PRC PRIMED team is on fire! 🔥
They recently hosted an incredible virtual seminar featuring Dr. Rhian Stavely, who delivered a fascinating talk titled:
"Understanding Enteric Neuroplasticity to Inform Regenerative Therapies."
Exciting insights and cutting-edge science—well done, team!

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

@ykmiura.bsky.social Welcome Dr. Miura!

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

Huge news! The Moayedi Lab has officially received their first R01 grant to study the neural mechanisms of astringency transduction and sensation! Can we get a whoop whoop hooray?! 🥳🎉🪩 @yaldamoayedi.bsky.social

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

A warm #welcome to Dr. Jordyn M. Boesch, our newest PRC Associate Member! 🐾 A board-certified veterinary anesthesiologist at Cornell, she’s now diving into translational research to bridge animal and human pain relief. #OneHealth #PainResearch blogs.cornell.edu/comparativep...

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

Thank you Brian Kim, MD, MTR for visiting the #NYU #PRC, giving a spectacular talk on neuroimmune interactions in bladder hypersensitivity and meeting with our members!

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

What a blast with Dr. Zhen Wang at PRC PRIMED! 🎉 His amazing talk, "An Interorgan Neuroimmune Circuit Drives Visceral Hypersensitivity," had us all engaged and inspired. #NeuroImmune #PRCPrimed #ScienceRocks 👏👏👏

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

PRC Highlight: Warm #welcome to Associate Member to the PRC! Kenny Chan, PhD studies how gut-brain-immune interactions under chronic stress drive depression and IBS—aiming to find targets to ease both neuropsychiatric and GI symptoms.

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

Flashback Friday! The PRC PRIMED was thrilled to welcome back Dr. Thomas Myers, a candidate in Dr. Robin Krimm’s lab at the University of Louisville. His engaging presentation, titled “Genetic Identification of a Fungiform-Innervating Low-Threshold Mechanoreceptor,” was a hit with everyone!

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

Amazing new paper from the Sadler Lab showing gut microbiota and metabolite contributions to pain in sickle cell disease. Congratulations to you and your team on this impressive work Kate! www.sciencedirect.com/science/arti... @katesadlerphd.bsky.social @utdpaincenter.bsky.social

Gut microbiota and metabolites drive chronic sickle cell disease pain in mice

Individuals with sickle cell disease (SCD) suffer from debilitating chronic pain that does not have a clear etiology. Recent 16S ribosomal RNA gene se…

www.sciencedirect.com

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NYU Pain Research Center @nyupainresearch.bsky.social · 19d

PRC Highlight: We are excited to #welcome Dr. Yuki Miura as an Associate Member to the PRC. Yuki’s work leverages stem cell–derived organoids and assembloids to model human neural circuits -level disruption contributes to neurological disorders and pain! 🧪🧑‍🔬 #YukiMiura #PRC

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NYU Pain Research Center @nyupainresearch.bsky.social · 21d

The PRC & Molecular Pathobiology Dept made a splash at the NYU Plenary! Great catching up with Jeff Love, Lillian Moran, Gretchen North, Dr. Sasan Rabieh, Dr. Denise Trochesset, Nuray Ozu, Dr. Davide Cuocolo, Candy Tobar & more! Till the spring

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NYU Pain Research Center @nyupainresearch.bsky.social · 23d

New research identifies SLC45A4 as a pain gene, encoding a neuronal polyamine transporter that shows genetic association with human pain. #therapeutictarget #paintreatment www.nature.com/articles/s41...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

www.nature.com

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NYU Pain Research Center @nyupainresearch.bsky.social · 28d

PRC Highlight: #MargolisLab making strides again! Congrats to Chalystha Lee who received the 2025 ISSR Travel Award at the #ISSR2025 hosted in Vienna! With mentorship from Dr. Kara Margolis & Dr. Michael Gershon lighting the way. #mentorship #ISSR #womeninresearch @chalysthalee.bsky.social

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NYU Pain Research Center @nyupainresearch.bsky.social · 28d

A new study sheds light on a potential new way to treat migraine. Activating the nociceptin receptor (NOP) system can block the pain caused by CGRP. A peripherally restricted compound showed the same efficacy as a brain-penetrant one. bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

BPS Publications

Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene-related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ recep...

bpspubs.onlinelibrary.wiley.com

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NYU Pain Research Center @nyupainresearch.bsky.social · 28d

New research on COVID-19 and pain reveals something fascinating. Researchers found that the SARS-CoV-2 nucleocapsid (N) protein can intensify and prolong pain by interacting with a key pain channel, Nav1.7. This discovery could open the door for new therapies. journals.lww.com/pain/fulltex...

SARS-CoV-2 N protein interacts with Nav1.7 to promote... : PAIN

ong COVID sequelae. The mechanisms underlying somatosensory abnormalities induced by SARS-CoV-2 remain largely unclear. In this study, we investigate the role of the SARS-CoV-2 nucleocapsid (N) protei...

journals.lww.com

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NYU Pain Research Center @nyupainresearch.bsky.social · 28d

The Margolis Lab had a great time at #ANMS2025 in Minneapolis! Postdocs Sarah, Lin & Chalystha gave abstract talks, PRC Director Kara closed the conference, and we met Keynote Speaker & 2021 Nobel Laureate David Julius and his team! #ANMS225

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NYU Pain Research Center @nyupainresearch.bsky.social · 28d

Why does pain persist in rheumatoid arthritis even when inflammation fades? New review uncovers how ectopic nociceptor sprouting may be the missing link, offering fresh targets beyond antirheumatic drugs. link.springer.com/article/10.1...

Ectopic Nociceptor Sprouting as a Key Peripheral Driver of Pain in Rheumatoid Arthritis - Current Rheumatology Reports

Purpose of review Pain is one of the most debilitating sequelae of rheumatoid arthritis. Established and emerging therapies offer effective disease control for many patients, though they often have un...

link.springer.com

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NYU Pain Research Center @nyupainresearch.bsky.social · 28d

Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications

Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

www.nature.com

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NYU Pain Research Center @nyupainresearch.bsky.social · Aug 29

Fascinating new study on TMD! Researchers found that TMJ injury leads to persistent pain behaviors and peripheral sensitization of trigeminal nociceptors in mice, with distinct sex-dependent effects. buff.ly/jsFza40

buff.ly

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NYU Pain Research Center @nyupainresearch.bsky.social · Aug 29

Incredible! A new imaging system has allowed researchers to map the entire adult mouse peripheral nervous system at micrometer resolution. This is a massive leap in understanding cellular interactions in health and disease. #Neuroscience www.sciencedirect.com/science/arti...

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution

In contrast to the rapid advancements in mesoscale connectomic mapping of the mammalian brain, similar mapping of the peripheral nervous system has re…

www.sciencedirect.com

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NYU Pain Research Center @nyupainresearch.bsky.social · Aug 29

Awesome new paper from the Khoutorsky Lab showing that transplanting healthy microbiota reduces fibromyalgia pain in mice and in humans! #microbiome #fibromyalgia #chronicpain www.cell.com/neuron/fullt...

The gut microbiota promotes pain in fibromyalgia

Cai et al. revealed that transplanting gut microbiota from women with fibromyalgia—a chronic widespread pain condition of unknown etiology—into mice induces pain. It also induces phenotypes commonly o...

www.cell.com

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