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Olivier Mathieu

@oliviermathieu.bsky.social

43 followers 28 following 5 posts

Biologist studying the molecular bases of epigenetics Research Director @CNRS @cnrs.bsky.social Group leader @iGReD_Clermont

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Olivier Mathieu @oliviermathieu.bsky.social · 5h

Thanks Ignacio

Olivier Mathieu @oliviermathieu.bsky.social · 2d

New record!

Reposted by Olivier Mathieu

CNRS Biologie @cnrsbiologie.bsky.social · 5d

#ResultatScientifique 🔎 L'équilibre entre activation et répression des gènes est crucial pour le développement et chez les plantes ils existent des protéines "gardiennes" de ce mécanisme !

✍️ O. Mathieu & G. Moissiard
👉 L'article dans @natplants.nature.com
buff.ly/v7R7mbj

Des protéines « gardiennes » préservent l’expression des gènes chez les plantes

Chez les organismes multicellulaires, l'équilibre entre l’activation et la répression des gènes est crucial pour le développement.

www.insb.cnrs.fr

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Olivier Mathieu @oliviermathieu.bsky.social · 2d

Thanks Lucas!

Olivier Mathieu @oliviermathieu.bsky.social · 2d

Our paper is finally out in Nature Plants. MAIL proteins antagonize Polycomb-mediated silencing. Full text here: rdcu.be/eJisX

Plant mobile domain protein–DNA motif modules counteract Polycomb silencing to stabilize gene expression

Nature Plants - This study reveals that plant proteins MAIL1, MAIN and MAIL2 function as anti-silencing factors that maintain active gene expression. They bind specific DNA motifs to prevent...

rdcu.be

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Reposted by Olivier Mathieu

manavellalab.bsky.social @manavellalab.bsky.social · Dec 30

Last good news from 2024!
Our latest paper on TE-derived small RNAs is finally out! It reveals a beautiful buffering mechanism involving epigenetics, chromatin organization, and pathogen resistance. A great collaboration with @plantevolution.bsky.social, don’t miss it!
www.nature.com/articles/s41...

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Reposted by Olivier Mathieu

EMBL Events @events.embl.org · Jan 27

📣 #EMBOMobileGenome is open for registrations!

Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍

📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl

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Reposted by Olivier Mathieu

PlantEvolution 🌱🌾 @plantevolution.bsky.social · Feb 10

In our latest @biorxiv-genomic.bsky.social preprint, we describe our approach to use PacBio HiFi reads to detect somatic TE transposition -- good enough to detect rare events that are present in only single cells. Led by Andrea Movilli.
#plantscience
www.biorxiv.org/content/10.1...

Diagram of somatic TE insertions across the A. thaliana genome

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Olivier Mathieu @oliviermathieu.bsky.social · Feb 13

while Plants == Mammals:
use(H3K4me3, mode="anti-DNA methylation", target="Arabidopsis")
www.nature.com/articles/s41...

Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis - Nature Plants

This study revealed that targeting H3K4me3 via the H3K4 methyltransferase SDG2 activates gene expression and removes DNA methylation by recruiting DNA demethylases. Conversely, the removal of H3K4me3 ...