github.com/KarchinLab/o...

Post 4/4
Hosted MCP endpoint: mcp.opencravat.org/sse (not a web page).
Claude: connect MCP server → URL above → No Auth → enable tools.
ChatGPT: Settings → Apps → Developer Mode → Create App → URL above → No Auth.
Also open source + runnable locally.

Post 3/4
Tools: coords, rsIDs, CAids, HGVS (g/c/p), protein missense → genomic HGVS via SynVar, + discover annotators/output fields. Uses GRCh38/hg38 + public OpenCRAVAT annotation service.

Post 2/4
More than “lookup”: give it a variant (rsID/HGVS/coords) and it returns clinical assertions (ClinVar/ClinGen, CIViC), population freqs (gnomAD + cohorts), effect predictors, + specialized resources (e.g., BRCA1 functional assay scores). Research/decision support ≠ clinical confirmation.

; (3) run non-sensitive analyses locally and scale compute in cloud for bulk jobs; (4) automate QC and reporting templates; (5) train non-programmer staff using the GUI. #annotator #opencravat #bioinformatics #opensource #genomics

Would you be interested in organizing or speaking at meetups, writing blog posts, or promoting the project?
Are you part of any communities or organizations where you could share our project?
#annotator #opencravat #bioinformatics #opensource #genomics

Would you be open to helping improve documentation or writing user guides?
Do you have skills in UI/UX design, and would you be interested in helping us improve the user interface?
#annotator #opencravat #bioinformatics #opensource #genomics

Would you be willing to review pull requests or help triage GitHub issues?
Can you help test new features or provide feedback on pre-release versions?
Would you be interested in setting up automated test cases or improving test coverage?
#annotator #opencravat #bioinformatics #opensource #genomics