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Kevin Baker

@orthoengineer.bsky.social

280 followers 320 following 81 posts

Husband | Father | Assoc. Scientist @hfhs-bjc.bsky.social, Assoc. Professor @ Michigan State CHM | Orthopaedic Research (mostly osteoarthritis and intervertebral disc degeneration) | All things: #Detroit, U.P., Great Lakes Freighters, Local Sports

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Kevin Baker @orthoengineer.bsky.social · Feb 4

ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!

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Kevin Baker @orthoengineer.bsky.social · 6d

The @tigers.bsky.social win in the Wild Card, 2 games to 1! The bats finally came alive and they had some clutch defense/pitching. Bless you boys and on to the Mariners! #Detroit

Kevin Baker @orthoengineer.bsky.social · 19d

Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!

Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · 19d

🚨🚨 New Publication Alert: The Ali Lab published a review on advancements in genomics, genetics, and epigenetics of #osteoarthritis. Fantastic work Thomas Wilson, Madhu Baghel and @amandality.bsky.social!

www.oarsijournal.com/article/S106...

Osteoarthritis year in review 2025: Genetics, genomics, and epigenetics

This review provides an overview of the work performed in the realms of genetics, genomics and epigenetics in osteoarthritis (OA) research over the past year.

www.oarsijournal.com

Kevin Baker @orthoengineer.bsky.social · Sep 2

Big thanks to CSRS for funding and to all of our co-authors! More data in the pipeline!

Kevin Baker @orthoengineer.bsky.social · Sep 2

We demonstrated that CCL5-loaded hydrogels efficiently recruited AMD3100-mobilized MSCs to target, degenerative lumbar discs in rats. Additionally, we showed beneficial effects (individual and combined) of systemic AMD3100 and local CCL5 delivery on microCT and histology of degenerative discs.

Kevin Baker @orthoengineer.bsky.social · Sep 2

Sharing our new publication on the topic of recruiting endogenous, pharmacologically-mobilized MSCs to degenerative lumbar intervertebral discs. Early results but step in the right direction! 1/
journals.sagepub.com/doi/full/10....

Local RANTES/CCL5 Delivery and Peripheral Blood Mobilization of Endogenous Marrow-Derived Mesenchymal Stem Cells to Mitigate Lumbar Intervertebral Disc Degeneration - Sapan Gandhi, Christopher S. Lai,...

Study Design Translational rodent study. Objectives To investigate (1) chemokine-mediated mesenchymal stem cell mobilization and homing to the intervertebral d...

journals.sagepub.com

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Kevin Baker @orthoengineer.bsky.social · Aug 16

Amazing #fishing trip to Northern Ontario with K1 before he moves in @umich.edu next week! 🥹

Kevin Baker @orthoengineer.bsky.social · Jul 31

More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.

Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · Jul 31

🚨🚨New publication alert! The Ali Lab @amandality.bsky.social ‬ in the @hfhs-bjc.bsky.social uses sequencing to profile microRNAs in early-stages of both osteoarthritis and rheumatoid arthritis! Now published in Scientific Reports ‪@natureportfolio.nature.com‬, read it here: rdcu.be/eylic

Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis

Scientific Reports - Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis

rdcu.be

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Kevin Baker @orthoengineer.bsky.social · Jul 26

Excited to put this new system to good use, and thankful for the rich history of uCT imaging here @hfhs-bjc.bsky.social from the Yeni Lab. Looking forward to some fun contrast-enhanced imaging of articular cartilage and intervertebral disc! #orthosky

Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · Jul 26

The Henry Ford Health Bone & Joint Center has a storied history with microCT imaging of MSK tissues, thanks primarily to Dr. Yeni's group. Today we took a large leap forward with the installation of a brand new Scanco MicroCT-90 system! #orthopaedics #imaging #bone #cartilage

Kevin Baker @orthoengineer.bsky.social · Jul 20

The @tigers.bsky.social are on a 6 game skid. The @detroitlions.bsky.social are in mid-season form with injuries nearly everyday. Only 6 more Saturdays until @umichfball.bsky.social, though!

Kevin Baker @orthoengineer.bsky.social · Jul 16

We got some fishing in on the Huron River yesterday in Ann Arbor after K1 finished new student orientation @umich.edu.

Kevin Baker @orthoengineer.bsky.social · Jun 30

Congrats, Blaine! Excellent study!

Kevin Baker @orthoengineer.bsky.social · Jun 23

This was a fantastic opportunity to strengthen ties with our @michiganstateu.bsky.social colleagues! Grateful to be able to share our stem cell mobilization work. Many thanks to the Co-Chairs @amandality.bsky.social @mattharkeyphd.bsky.social, Charles Day MD and Jane Manfredi DVM PhD!

Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · Jun 23

Members of the Bone & Joint Center had a great time sharing and learning about musculoskeletal research at @michiganstateu.bsky.social and @henryfordhealth.bsky.social during the HFH+MSU Musculoskeletal Research Retreat. Our Chairman @shouldergeek.bsky.social delivered inspiring opening remarks!

Jonathan Braman, MD (Chair, Orthopaedic Surgery at Henry Ford Health) delivers opening remarks at the Henry Ford + Michigan State University Musculoskeletal Research Retreat held in East Lansing, MI on 06/17/2025.

Kevin Baker @orthoengineer.bsky.social · Jun 2

Sending positive thoughts from across the river, Frank!

Kevin Baker @orthoengineer.bsky.social · May 30

Without generous philanthropic support, this project would not have been possible. Special shout outs to (known) Bluesky co-authors @maerzlab.bsky.social @zlammlin.bsky.social @eriebaker.bsky.social @hfhs-bjc.bsky.social @henryfordhealth.bsky.social @umich.edu @corewellhealth.bsky.social

Kevin Baker @orthoengineer.bsky.social · May 30

Our paper on enhancing the repair of #RotatorCuff tears using pharmacologic methods to recruit endogenous MSCs is out in AJSM today! The project was fun, but I can't say enough about my amazing co-authors. Read it here:
journals.sagepub.com/doi/10.1177/...

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Kevin Baker @orthoengineer.bsky.social · May 19

Tariff on the new microCT we purchased will be somewhere between 0 and 32%. Cool. Cool, cool.

Kevin Baker @orthoengineer.bsky.social · May 14

Not until Javy says so...

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Reposted by Kevin Baker

Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · May 10

Another fantastic @henryfordhealth.bsky.social Research Symposium in the books! Inspiring to hear about all of the awesome research from across the campus. Equally amazing to hear from @boneybonebone.bsky.social of the Yeni Lab @hfhs-bjc.bsky.social talking about facet joint measurement via DTS!

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Kevin Baker @orthoengineer.bsky.social · Apr 18

Not sure that was eccentric, but a good representation nonetheless.

Kevin Baker @orthoengineer.bsky.social · Apr 17

This is acceptable for walks that cost the pitcher 9+ throws.

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Kevin Baker @orthoengineer.bsky.social · Apr 16

Save some tenure for the rest of us, dude.

Kevin Baker @orthoengineer.bsky.social · Mar 27

I respect your 🇨🇦 pandering in times like these.

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Kevin Baker @orthoengineer.bsky.social · Mar 27

K1 sent pics below of the 🇳🇱 flagged Iver Bright tanker (left) and the 989 ft. M/V American Century diesel-powered freighter (right) while fishing on the St. Clair River.

Kevin Baker @orthoengineer.bsky.social · Mar 20

A new manuscript acceptance was a much needed win this week. So grateful to work with smart people! More to come on the accepted manuscript once proofs are up. For now, I'll just say that it is pretty cool that we can convince cells to go to specific places...like the #rotatorcuff maybe?

shrek from the movie shrek looks at the camera

ALT: shrek from the movie shrek looks at the camera

media.tenor.com

Kevin Baker @orthoengineer.bsky.social · Mar 14

With the @tigers.bsky.social home opener less than two weeks away, it's time to channel Sparky Anderson. #GrittyTigers #Detroit