Kevin Baker
@orthoengineer.bsky.social
Husband | Father | Assoc. Scientist @hfhs-bjc.bsky.social, Assoc. Professor @ Michigan State CHM | Orthopaedic Research (mostly osteoarthritis and intervertebral disc degeneration) | All things: #Detroit, U.P., Great Lakes Freighters, Local Sports
Pinned
ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!
Awesome to see our Department Chair @shouldergeek.bsky.social and members of the @henryfordhealth.bsky.social Sports Med team at America's Thanksgiving Parade in #Detroit!
November 27, 2025 at 3:15 PM
Awesome to see our Department Chair @shouldergeek.bsky.social and members of the @henryfordhealth.bsky.social Sports Med team at America's Thanksgiving Parade in #Detroit!
Who says PIs dont stand by their posters!? Presenting our ACL reconstruction research at #TERMISAM2025 in #Detroit.
November 10, 2025 at 8:34 PM
Who says PIs dont stand by their posters!? Presenting our ACL reconstruction research at #TERMISAM2025 in #Detroit.
Fantastic time at the 18th World Congress of the International Cartilage Regeneration & Joint Preservation Society in Boston. Presented our work on IDO-1 and #Kynurenines in #osteoarthritis, and a project focused on improved healing in #ACL reconstruction. As always - huge thanks to the team!
October 17, 2025 at 5:05 PM
Fantastic time at the 18th World Congress of the International Cartilage Regeneration & Joint Preservation Society in Boston. Presented our work on IDO-1 and #Kynurenines in #osteoarthritis, and a project focused on improved healing in #ACL reconstruction. As always - huge thanks to the team!
Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!
🚨🚨 New Publication Alert: The Ali Lab published a review on advancements in genomics, genetics, and epigenetics of #osteoarthritis. Fantastic work Thomas Wilson, Madhu Baghel and @amandality.bsky.social!
www.oarsijournal.com/article/S106...
www.oarsijournal.com/article/S106...
Osteoarthritis year in review 2025: Genetics, genomics, and epigenetics
This review provides an overview of the work performed in the realms of genetics,
genomics and epigenetics in osteoarthritis (OA) research over the past year.
www.oarsijournal.com
September 20, 2025 at 2:10 PM
Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!
Sharing our new publication on the topic of recruiting endogenous, pharmacologically-mobilized MSCs to degenerative lumbar intervertebral discs. Early results but step in the right direction! 1/
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Local RANTES/CCL5 Delivery and Peripheral Blood Mobilization of Endogenous Marrow-Derived Mesenchymal Stem Cells to Mitigate Lumbar Intervertebral Disc Degeneration - Sapan Gandhi, Christopher S. Lai,...
Study Design Translational rodent study. Objectives To investigate (1) chemokine-mediated mesenchymal stem cell mobilization and homing to the intervertebral d...
journals.sagepub.com
September 2, 2025 at 2:35 PM
Sharing our new publication on the topic of recruiting endogenous, pharmacologically-mobilized MSCs to degenerative lumbar intervertebral discs. Early results but step in the right direction! 1/
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Amazing #fishing trip to Northern Ontario with K1 before he moves in @umich.edu next week! 🥹
August 16, 2025 at 9:12 PM
Amazing #fishing trip to Northern Ontario with K1 before he moves in @umich.edu next week! 🥹
More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.
🚨🚨New publication alert! The Ali Lab @amandality.bsky.social in the @hfhs-bjc.bsky.social uses sequencing to profile microRNAs in early-stages of both osteoarthritis and rheumatoid arthritis! Now published in Scientific Reports @natureportfolio.nature.com, read it here: rdcu.be/eylic
Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis
Scientific Reports - Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis
rdcu.be
July 31, 2025 at 2:18 PM
More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.
Excited to put this new system to good use, and thankful for the rich history of uCT imaging here @hfhs-bjc.bsky.social from the Yeni Lab. Looking forward to some fun contrast-enhanced imaging of articular cartilage and intervertebral disc! #orthosky
The Henry Ford Health Bone & Joint Center has a storied history with microCT imaging of MSK tissues, thanks primarily to Dr. Yeni's group. Today we took a large leap forward with the installation of a brand new Scanco MicroCT-90 system! #orthopaedics #imaging #bone #cartilage
July 26, 2025 at 12:55 AM
Excited to put this new system to good use, and thankful for the rich history of uCT imaging here @hfhs-bjc.bsky.social from the Yeni Lab. Looking forward to some fun contrast-enhanced imaging of articular cartilage and intervertebral disc! #orthosky
We got some fishing in on the Huron River yesterday in Ann Arbor after K1 finished new student orientation @umich.edu.
July 16, 2025 at 4:59 PM
We got some fishing in on the Huron River yesterday in Ann Arbor after K1 finished new student orientation @umich.edu.
This was a fantastic opportunity to strengthen ties with our @michiganstateu.bsky.social colleagues! Grateful to be able to share our stem cell mobilization work. Many thanks to the Co-Chairs @amandality.bsky.social @mattharkeyphd.bsky.social, Charles Day MD and Jane Manfredi DVM PhD!
Members of the Bone & Joint Center had a great time sharing and learning about musculoskeletal research at @michiganstateu.bsky.social and @henryfordhealth.bsky.social during the HFH+MSU Musculoskeletal Research Retreat. Our Chairman @shouldergeek.bsky.social delivered inspiring opening remarks!
June 23, 2025 at 2:14 PM
This was a fantastic opportunity to strengthen ties with our @michiganstateu.bsky.social colleagues! Grateful to be able to share our stem cell mobilization work. Many thanks to the Co-Chairs @amandality.bsky.social @mattharkeyphd.bsky.social, Charles Day MD and Jane Manfredi DVM PhD!
Our paper on enhancing the repair of #RotatorCuff tears using pharmacologic methods to recruit endogenous MSCs is out in AJSM today! The project was fun, but I can't say enough about my amazing co-authors. Read it here:
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
May 30, 2025 at 2:06 PM
Our paper on enhancing the repair of #RotatorCuff tears using pharmacologic methods to recruit endogenous MSCs is out in AJSM today! The project was fun, but I can't say enough about my amazing co-authors. Read it here:
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Reposted by Kevin Baker
Another fantastic @henryfordhealth.bsky.social Research Symposium in the books! Inspiring to hear about all of the awesome research from across the campus. Equally amazing to hear from @boneybonebone.bsky.social of the Yeni Lab @hfhs-bjc.bsky.social talking about facet joint measurement via DTS!
May 10, 2025 at 2:27 AM
Another fantastic @henryfordhealth.bsky.social Research Symposium in the books! Inspiring to hear about all of the awesome research from across the campus. Equally amazing to hear from @boneybonebone.bsky.social of the Yeni Lab @hfhs-bjc.bsky.social talking about facet joint measurement via DTS!
K1 sent pics below of the 🇳🇱 flagged Iver Bright tanker (left) and the 989 ft. M/V American Century diesel-powered freighter (right) while fishing on the St. Clair River.
March 27, 2025 at 12:50 AM
K1 sent pics below of the 🇳🇱 flagged Iver Bright tanker (left) and the 989 ft. M/V American Century diesel-powered freighter (right) while fishing on the St. Clair River.
With the @tigers.bsky.social home opener less than two weeks away, it's time to channel Sparky Anderson. #GrittyTigers #Detroit
March 14, 2025 at 1:10 PM
With the @tigers.bsky.social home opener less than two weeks away, it's time to channel Sparky Anderson. #GrittyTigers #Detroit
Great paper from @boneybonebone.bsky.social of the Yeni Lab in the @hfhs-bjc.bsky.social. DTS could be very useful for understanding facet joint loading associated with spondyloarthropathies, or even new interbody or interspinous spacer devices! #Orthosky #Spine
New paper from Dr. Yeni, @boneybonebone.bsky.social, et al. just published in @jbiomech.bsky.social! The team used digital tomosynthesis (DTS) to quantify spinal facet joint width. They also showed that this technique can be used in vivo to dynamically observe human facet joint loading! #Orthosky
March 1, 2025 at 7:37 PM
Great paper from @boneybonebone.bsky.social of the Yeni Lab in the @hfhs-bjc.bsky.social. DTS could be very useful for understanding facet joint loading associated with spondyloarthropathies, or even new interbody or interspinous spacer devices! #Orthosky #Spine
Grateful to be a (very) small part of such an amazing study! All credit to the awesome @amandality.bsky.social and her team for this important #osteoarthritis discovery just published in @naturecomms.bsky.social. The miR-evolution is now!
Excited to share our work on the small but mighty microRNA-126-3p in @naturecomms.bsky.social! We found this microRNA is elevated in four knee osteoarthritis cohorts and show in an animal model that it reduces the severity of knee osteoarthritis - at least in part via angiogenesis. rdcu.be/ebycj
February 27, 2025 at 10:00 PM
Grateful to be a (very) small part of such an amazing study! All credit to the awesome @amandality.bsky.social and her team for this important #osteoarthritis discovery just published in @naturecomms.bsky.social. The miR-evolution is now!
A very Detroit end to day spent helping some neighbors. Spotted this pheasant pair just off Kercheval and Field. (Sorry for the poor quality)
February 15, 2025 at 5:35 PM
A very Detroit end to day spent helping some neighbors. Spotted this pheasant pair just off Kercheval and Field. (Sorry for the poor quality)
ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!
February 4, 2025 at 4:54 PM
ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!
Our folks just sent pictures of the St. Clair River in East China, Michigan. Lots of ice piling up and the CGC Mackinaw cutting a path.
January 25, 2025 at 7:10 PM
Our folks just sent pictures of the St. Clair River in East China, Michigan. Lots of ice piling up and the CGC Mackinaw cutting a path.
Was great to be back at @michigantech.bsky.social and hanging in the Keweenaw Peninsula again for a few days!
January 18, 2025 at 10:24 PM
Was great to be back at @michigantech.bsky.social and hanging in the Keweenaw Peninsula again for a few days!
Took advantage of the unseasonable weather today and went fishing with the whole family on the Huron River in Ann Arbor. No fish but plenty of fresh air and sunshine!
December 28, 2024 at 10:54 PM
Took advantage of the unseasonable weather today and went fishing with the whole family on the Huron River in Ann Arbor. No fish but plenty of fresh air and sunshine!
Time to get the new printer up and running for the boys!
December 27, 2024 at 6:03 PM
Time to get the new printer up and running for the boys!
The 1,013.5 ft. M/V Paul R. Tregurtha was anchored just offshore in East China, Michigan on the St. Clair River today. Longest #freighter on the #GreatLakes!
December 25, 2024 at 1:07 AM
The 1,013.5 ft. M/V Paul R. Tregurtha was anchored just offshore in East China, Michigan on the St. Clair River today. Longest #freighter on the #GreatLakes!
I love the random, amazing stuff one can find walking around Detroit...like this awesome firetruck in Corktown!
December 21, 2024 at 10:25 PM
I love the random, amazing stuff one can find walking around Detroit...like this awesome firetruck in Corktown!
The Tryptophan slander is egregious this Thanksgiving. Like, do you want neurotransmitters? Would you like some NAD+, or we just skipping Kynurenines altogether?
November 29, 2024 at 9:27 PM
The Tryptophan slander is egregious this Thanksgiving. Like, do you want neurotransmitters? Would you like some NAD+, or we just skipping Kynurenines altogether?