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Oxford University Clinical Research Unit @oucru.bsky.social · 7h

www.oucru.org/oucru-contri...

OUCRU contributes to defining the first core outcome measurement set for Dengue - OUCRU

A major international collaboration between ISARIC researchers at King’s College London and the Oxford University Clinical Research Trials Unit (OUCRU) has created the first global Core Outcome Measur...

www.oucru.org

Oxford University Clinical Research Unit @oucru.bsky.social · 7h

Read the paper: www.thelancet.com/journals/lan...

Core outcome measurement set for clinical trials in dengue: an international Delphi consensus study (DEN-CORE)

Dengue, caused by any one of four distinct virus serotypes, is the most rapidly spreading mosquito-borne viral disease worldwide. It is a primary arboviral infection with increasing global incidence, ...

www.thelancet.com

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Oxford University Clinical Research Unit @oucru.bsky.social · 7h

Sophie Yacoub, Co-Lead of the DEN-CORE Project and former Head of OUCRU Dengue Research Team, shared: “Bringing together a global consensus on clinically relevant outcomes to be measured in all future dengue clinical trials is a major step forward for the dengue therapeutics field.”

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Oxford University Clinical Research Unit @oucru.bsky.social · 7h

📢 A major international collaboration between ISARIC researchers at @kingscollegelondon.bsky.social and OUCRU has created the first global Core Outcome Measurement Set (COMS) for dengue clinical trials.

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Oxford University Clinical Research Unit @oucru.bsky.social · 1d

www.oucru.org/oucru-workshop-on-early-warning-systems-for-climate-sensitive-infectious-diseases/

OUCRU workshop drives dialogue on early warning systems for climate-sensitive infectious diseases - OUCRU

Researchers, policymakers, and health professionals gathered at the Oxford University Clinical Research Unit (OUCRU) for a workshop on “Enablers and Barriers to Development and Implementation of Early...

www.oucru.org

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Oxford University Clinical Research Unit @oucru.bsky.social · 1d

💡 #AWARE is a three-year global initiative (2023–2025) led by Brown University Pandemic Center and funded by the Gates Foundation Gates Ventures and Wellcome Trust. Together with Brazil, Kenya & South Africa, Vietnam’s experience highlights the country as a model for outbreak preparedness.

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Oxford University Clinical Research Unit @oucru.bsky.social · 1d

Participants discussed the barriers and enablers to implementing early warning and response systems for climate-sensitive infectious diseases and exchanged ideas on how to scale and sustain these efforts.

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Oxford University Clinical Research Unit @oucru.bsky.social · 1d

OUCRU recently hosted a workshop to share the #AWARE study findings, bringing together more than 30 healthcare professionals, policymakers, and hospital representatives from across Vietnam.

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Oxford University Clinical Research Unit @oucru.bsky.social · 1d

Vietnam is among the countries most affected by #climatechange, driving the spread of infectious diseases.

Our 𝗔𝗱𝘃𝗮𝗻𝗰𝗲 𝗪𝗮𝗿𝗻𝗶𝗻𝗴 𝗮𝗻𝗱 𝗥𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝗘𝘅𝗲𝗺𝗽𝗹𝗮𝗿𝘀 𝗔𝗪𝗔𝗥𝗘 study explored how advanced tools can be integrated into national surveillance systems to strengthen outbreak prediction and preparedness.

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Oxford University Clinical Research Unit @oucru.bsky.social · 7d

This appointment underlines OUCRU Vietnam’s continued commitment to strengthening research capacity and supporting the development of future scientists and healthcare professionals in Vietnam.

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Oxford University Clinical Research Unit @oucru.bsky.social · 7d

Dr Minh conducted his PhD research at OUCRU and was awarded his degree in 2014 by @theOpenUniversity United Kingdom. He has worked at Children’s Hospital 1 since 1998 and, over nearly three decades, has taken on a series of leadership roles.

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Oxford University Clinical Research Unit @oucru.bsky.social · 7d

𝗢𝗨𝗖𝗥𝗨 𝗮𝗹𝘂𝗺𝗻𝘂𝘀 𝗮𝗽𝗽𝗼𝗶𝗻𝘁𝗲𝗱 𝗮𝘀 𝗻𝗲𝘄 𝗗𝗶𝗿𝗲𝗰𝘁𝗼𝗿 𝗼𝗳 𝗖𝗵𝗶𝗹𝗱𝗿𝗲𝗻’𝘀 𝗛𝗼𝘀𝗽𝗶𝘁𝗮𝗹 𝟭, 𝗛𝗼 𝗖𝗵𝗶 𝗠𝗶𝗻𝗵 𝗖𝗶𝘁𝘆, 𝗩𝗶𝗲𝘁𝗻𝗮𝗺

Dr Ngô Ngọc Quang Minh, an OUCRU PhD graduate, has been appointed as the new Director of Children’s Hospital 1, the leading paediatric referral hospital for Ho Chi Minh City and southern Vietnam.

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Oxford University Clinical Research Unit @oucru.bsky.social · 24d

👉 Follow #MODRA journey and see how these emerging scientists will shape the future of global health!

Oxford University Clinical Research Unit @oucru.bsky.social · 24d

They also connected with leading experts and trainers in infectious diseases and global health, gaining more than knowledge: the confidence to think big, the tools to act, and a network of mentors and peers to support them well into their careers.

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Oxford University Clinical Research Unit @oucru.bsky.social · 24d

🔥 Each had drafted a seed award proposal – with the chance to secure up to USD 30,000 to launch their research.

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Oxford University Clinical Research Unit @oucru.bsky.social · 24d

At their first intensive training week in Bangkok, participants reflected on their strengths, explored new approaches through design thinking, and gained practical skills in leadership, budgeting, and proposal writing.

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Oxford University Clinical Research Unit @oucru.bsky.social · 24d

Fifteen emerging scientists from South and Southeast Asia begin an 18-month journey with the 𝗠𝗢𝗥𝗨-𝗢𝗨𝗖𝗥𝗨 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗔𝗰𝗮𝗱𝗲𝗺𝘆 (𝗠𝗢𝗗𝗥𝗔). This programme equips early-career postdoctoral researchers with the skills, networks, and confidence to transform research ideas into real-world impact.

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 21

To our knowledge, this is the first time scRNA-seq has been applied to examine CSF in adult TBM patients in the world.

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 21

www.oucru.org/new-study-ma...

New study maps immune cells fuelling harmful inflammation in tuberculous meningitis - OUCRU

Tuberculous meningitis harms not only through infection, but also through the body’s own overactive immune response. Using single-cell RNA sequencing, OUCRU scientists have identified specific immune ...

www.oucru.org

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 21

The team also established a clear workflow and analysis pipeline for paired CSF and blood samples. This lays the foundation for larger studies to explore disease mechanisms and develop new treatment strategies for TBM and other brain infections.

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 21

Using the advanced single-cell RNA sequencing (scRNA-seq) technique, a team of OUCRU researchers has mapped key immune cells in cerebrospinal fluid that may be driving inflammation in TBM patients.

This shows the potential to explore new targeted treatments to reduce immune-mediated brain injury.

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 21

Tuberculous meningitis (TBM) is the most severe and life-threatening form of tuberculosis. Even with treatment, it carries a high fatality rate of 20% to 50%. Half of survivors live with permanent neurological complications.

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 21

New study from OUCRU maps the immune cells fuelling inflammation in tuberculous meningitis – the deadliest form of TB 🔥

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 7

Professor Timothy Walker is part of OUCRU’s #Tuberculosis (TB) research group. His work integrates genomics, pharmacology, and public health to tackle drug-resistant TB and sustain the global effectiveness of TB control efforts.

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Oxford University Clinical Research Unit @oucru.bsky.social · Aug 7

Professor Louise Thwaites' work has transformed #ICU care in resource-limited settings, from practice defining clinical trials to launching #VITAL, an innovation hub for low-cost diagnostic tools. She now leads a Wellcome Trust-funded #AI project to advance pneumonia research and care.

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