A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Polycomb chromatin domains are chromosomal regions decorated with histone H2A monoubiquitination at lysine 119 (H2Aub1) and histone H3 trimethylation at lysine 27 (H3K27me3). These domains are dynamic...

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Paternal exercise influences exercise capacity and metabolic health of offspring, but the underlying mechanisms remain poorly understood. We demonstra…

Polycomb group (PcG) proteins form chromatin modifying complexes that stably repress lineage- or context-specific genes in animals, plants, and som...

Site-specific DNA binding by proteins is critical for regulating transcriptional activity and cell fate decision. However, identifying proteins bou...

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An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

And would we ever elect an atheist?

In the intricate dance of gene regulation that governs plant and animal development, Polycomb group proteins have historically taken center stage. These proteins orchestrate gene silencing by catalyzing the trimethylation of lysine 27 on histone H3 (H3K27me3), a well-known epigenetic mark responsible for maintaining genes in an inactive state. This regulatory mechanism has been widely studied for its pivotal role in developmental pathways and cellular differentiation, yet a lingering question remains: how do some actively transcribed genes evade this silencing machinery despite possessing features that would typically attract Polycomb-mediated repression?

ABSTRACT. Our current understanding of the molecular basis of embryonic development and the shared machinery underlying this remarkable process has its roots in three papers published 40 years ago, wh...

Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare?

My wife and I are off to Spain in a few days, so this will be my last column for a couple weeks. I mention Spain not that you’re especially interested in my ...

The Official U.S. Congressional website of Congresswoman Yassamin Ansari

Mediterranean olive groves, which have long been symbols of tradition and culinary heritage, now reveal warning signs of rapidly declining soil health across Europe’s agricultural landscapes. Driven by intensive farming, climate pressures and policy gaps, accelerating soil loss threatens both ecosystem health and rural livelihoods, signalling a critical need for sustainable soil management and adaptive strategies.

Homenaje con ocasión del centenario del nacimiento delprofesor Emiliano Aguirre  en el Museo Nacional de Ciencias Naturales