Lightnews — Scholar-powered news

PacBio

@pacbio.bsky.social

5.4K followers 12K following 400 posts

Our mission is to enable the promise of genomics to better human health by creating the world’s most advanced sequencing technologies.

Posts Media Videos Starter Packs

Pinned

PacBio @pacbio.bsky.social · Nov 12

A little birdie told us we should migrate to bluer skies. 😉 Hello Bluesky world. 👋🌎 Please re-share this post so we can follow you and help to grow the genomics community on here! 🧬✨

6 68 170

PacBio @pacbio.bsky.social · 2h

Just in: #PacBio HiFi long-read sequencing is powering the National Institute on Aging’s Long Life Family Study.

Up to 7,800 genomes and epigenomes will be sequenced on Revio systems to uncover rare variants, methylation patterns, and other factors linked to healthy aging.

🔗 bit.ly/3IUDdFo

2 2

PacBio @pacbio.bsky.social · 22h

In a landmark #PopulationGenomics study, All of Us researchers used #HiFisequencing of 1,027 participants to identify hundreds of #StructuralVariants disease associations, with over half missed by short reads. What are you missing in your research?

Read the study here: bit.ly/4ocq49K

#PacBio

Population-scale Long-read Sequencing in the All of Us Research Program

The All of Us Research Program (AoU) is a national biobank seeking to enroll one million individuals in the United States to link genomic and biomedical data, including short- and long-read whole-geno...

bit.ly

1 4

PacBio @pacbio.bsky.social · 1d

#PacBio expands its partnership with @seqwell.bsky.social to bring the LongPlex™ Multiplexing Kit to more labs.

LongPlex™ complements #HiFisequencing with streamlined tagmentation and multiplexing to deliver faster, cost-efficient prep for population-scale studies.

Press release: bit.ly/48Y3z3I

PacBio @pacbio.bsky.social · 1d

Join our second #ASHG25 CoLab at 2:30pm in CoLab Theater 2!

Explore how #PacBio HiFi multiomics connects genomes, transcriptomes, and proteomes to reveal links between genetic variation, isoforms, and protein diversity.

Full program here: bit.ly/4nmBnfn

PacBio @pacbio.bsky.social · 2d

The 2025 #Epigenetics SMRT Grant is open!

Submit a 100-word proposal for a chance to win free sequencing with Fiber-seq, which combines genome sequence, 5mC methylation, and chromatin accessibility for a multiomic view of regulation.

Apply here: bit.ly/4nGQrEW

1 3

PacBio @pacbio.bsky.social · 4d

Join our first #ASHG25 CoLab at 3:15pm in CoLab Theater 1!

Explore how #PacBio PureTarget enables PCR-free #HiFisequencing of challenging genes for high-throughput germline diagnostics and custom disease research panels.

More details here: bit.ly/4nmBnfn

PacBio @pacbio.bsky.social · 5d

Tandem repeats are a blind spot in genomics despite their link to disease.

Hear Egor Dolzhenko from #PacBio explain how TRGT with HiFi sequencing resolves them and don’t miss his #ASHG25 platform talk on computational analysis of tandem repeats.

Watch: bit.ly/4o1Jez5

1 2

PacBio @pacbio.bsky.social · 5d

Did you know? Revio & Vega include on-instrument 6mA calling for the Fiber-seq chromatin accessibility assay. Thanks to Fiber-seq expert @mrvollger.bsky.social for the thoughtful evaluation and recommendation.

Reagents for the assay are also available from our friends at EpiCypher: bit.ly/42YwGQE

3 5

PacBio @pacbio.bsky.social · 6d

Struggling with complex single-gene disorders like Thalassemia?

Traditional short reads often miss key variants. With HiFi + Vega, Berry Genomics increased diagnosis rates and accelerated R&D.

See how HiFi is transforming genomics: bit.ly/4gGkp9t

#TheresHiFiForThat

PacBio @pacbio.bsky.social · 6d

Discover highly accurate PacBio #HiFisequencing for #AAVResearch.

Sequence full-length AAV genomes to characterize vectors, optimize designs, uncover novel capsids, and assess host genome integration events.

📄 Read the app brief: bit.ly/473ogdb

#PacBio #GeneTherapy

PacBio @pacbio.bsky.social · 7d

"It’s a 10 but… their sequencing misses the repeats."

@alexdainis.bsky.social puts the trend to the test in the lab. 👩‍🔬

Want the full story? The Sequencing 101 guide shows best practices every lab should know: bit.ly/4gGkp9t

#TheresHiFiForThat

PacBio @pacbio.bsky.social · 7d

Group chat on speakerphone means fragments, overlaps, confusion.

Short reads do the same to transcripts.

HiFi = every isoform, end to end.

📘 Get the Seq 101 guide: bit.ly/4gGkp9t

#TheresHiFiForThat #PacBio #ScienceHumor

PacBio @pacbio.bsky.social · 8d

Two weeks to go until #ASHG25! 🎉

Stop by to see #PacBio Revio and Vega in action, chat with our scientists, and explore how long-read sequencing is shaping the future of human genomics.

Boston, we’re ready for you!

Details here: bit.ly/4nmBnfn

PacBio @pacbio.bsky.social · 8d

Join us at the PacBio Industry Workshop at #ASHG25! Celebrate 25 years of #PacBio innovation and explore the future of genomics with HiFi sequencing.

📅 Friday, Oct 17 | 12–1pm ET

Learn how PacBio technology can enhance your research. Details here: bit.ly/4nmBnfn

PacBio @pacbio.bsky.social · 9d

The 2025 Long-Read Low Pass SMRT Grant is calling for proposals in plant + animal sciences! 🌱🐾

Two winners will receive free #PacBio HiFi sequencing to advance conservation or agricultural research.

Apply with your 100-word proposal: bit.ly/3IgrReu

1 2

PacBio @pacbio.bsky.social · 11d

🎉 #PacBio is turning 25 and we are bringing the #PacBioBlockParty to #ASHG25. Join us for a night of celebration with the genomics community.

And a big thanks to our sponsors for their support: SPT Labtech, Twist Bioscience, Hamilton, and n6!

Spaces are filling up fast! RSVP today: bit.ly/46xnUeI

1 2

PacBio @pacbio.bsky.social · 12d

Vega in the lab. Revio at Gene Omics.

Dr. Ibrahim Bitar knows how to make microbial genomics work.

Curious? Start with the Seq 101 guide: bit.ly/4gGkp9t

#TheresHiFiForThat #PacBio #Genomics

1 1

PacBio @pacbio.bsky.social · 12d

Carrier screening doesn’t have to be fragmented.

PacBio #PureTarget powered by #HiFisequencing enables labs to replace legacy assays and resolve challenging genes like FMR1, SMN1, and HBA1/2 in one workflow with high-confidence insights.

Read more in the blog: bit.ly/3KiqLQd

How PureTarget is modernizing research into carrier screening - PacBio

Puretarget kits bring HiFi long-read sequencing to carrier screening research and modernizes how labs approach inherited disease.

https://bit.ly/3KiqLQd"

PacBio @pacbio.bsky.social · 13d

Can one test replace many?

A JAMA Pediatrics study by @childrensmercy.org evaluated long-read HiFi sequencing as a first-line approach for pediatric rare disease research, with potential to improve solves, reduce turnaround time, and bypass multiple sequential testing.

Read more: bit.ly/3VtHjHh

Children's Mercy @childrensmercy.org · 15d

Our new study in Journal of the American Medical Association Pediatrics shows a single long-read sequencing test can ID rare genetic conditions in kids faster & more accurately. This means fewer tests, quicker answers & a potential breakthrough.
@research.childrensmercy.org
https://cmkc.link/4gFemlo

Unlocking Answers Faster: Children’s Mercy Revolutionizes Genetic Disease Diagnosis with a Single-Test

Children’s Mercy, one of the nation’s top independent pediatric health systems, is once again leading the way in genomic medicine. In a landmark study, published in the prestigious Journal of the Amer...

cmkc.link

1 2

PacBio @pacbio.bsky.social · 13d

⏰ Last call! The human #microbiome webinar is tomorrow.

See how #PacBio HiFi sequencing delivers clarity with full-length 16S rRNA and shotgun metagenomics, revealing strain-level insights, novel taxa, and functional pathways.

Register now: bit.ly/46wBttB

PacBio @pacbio.bsky.social · 14d

GRWM: Sequencing microbes. 👩‍🔬✨

@alexdainis.bsky.social shows how HiFi plex prep takes you from iced coffee → pipettes → complete genomes. #TheresHiFiForThat

Download the Seq 101 guide + you could join us at a 2026 genomics conference of your choice: bit.ly/4gGkp9t

1 3

PacBio @pacbio.bsky.social · 14d

Our PacBio #PureTarget launch is making waves.

Conor Hale at @FierceBiotech was among those covering how new carrier screening panels bring accuracy, scale, and efficiency to family planning research labs.

Read more: bit.ly/425REwJ

#PacBio #CarrierScreening #HiFisequencing

PacBio @pacbio.bsky.social · 15d

👯 Alleles. Variants. Repeats. Isoforms.

If it looks the same, HiFi shows you where it’s not.

#TheresHiFiForThat → bit.ly/3JminPa

PacBio @pacbio.bsky.social · 15d

🚨 Last call! This week, join PAG’s free webinar to see how long-read low-pass sequencing and pangenomes are reshaping #genomics.

From structural variation to trait discovery, explore scalable insights across species. Sponsored by #PacBio.

Register: bit.ly/4mbCkFU

1 2

PacBio @pacbio.bsky.social · 15d

Heading to #ASHG25? Visit #PacBio at booth 919!

Connect with our team, explore live demos of #Revio and #Vega, and discover the latest in long-read sequencing. While you’re there, enter our daily Labubu drawing!

See the full program here: bit.ly/4nnRGbn