Lightnews — Scholar-powered news

Pagès lab

@pageslab.bsky.social

520 followers 190 following 7 posts

DNA damage and genome instability group Cancer Research Center of Marseille. #DNAdamage, #TranslesionSynthesis, #HomologousRecombination, in bacteria & yeast

Posts Media Videos Starter Packs

Pagès lab @pageslab.bsky.social · 26d

open access version here: hal.science/hal-05250217

The RecBC complex protects single-stranded DNA gaps during lesion bypass

Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication...

hal.science

1 4

Pagès lab @pageslab.bsky.social · 26d

New paper out! We show that RecBC remodels single-stranded DNA gaps to protect them from ExoI (sbcB) 3′-5′ exonuclease degradation during replication of damaged DNA.

doi.org/10.1073/pnas...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

doi.org

1 3 4

Reposted by Pagès lab

CNRS Biologie @cnrsbiologie.bsky.social · Apr 11

#RésultatScientifique 🔎 Découvrez la dernière publication de Vincent Pagès et de ses collaborateurs !

🤝 @cnrs-dr12.bsky.social @insermpacacorse.bsky.social @univ-amu.fr @paoli-calmettes.bsky.social @pageslab.bsky.social @crcm.bsky.social

👉 @narjournal.bsky.social
buff.ly/rVeGV9B

4 4

Pagès lab @pageslab.bsky.social · Mar 25

Thanks Annabel!

Pagès lab @pageslab.bsky.social · Mar 24

Our key findings:
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS

Pagès lab @pageslab.bsky.social · Mar 24

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability.
doi.org/10.1093/nar/...

4 6 12

Pagès lab @pageslab.bsky.social · Feb 25

How does Pol IV overcome strong replication blocks in E. coli? Our latest study with @joeloparo.bsky.social uncovers a bipartite clamp interaction that helps Pol IV compete with Pol III, enabling efficient TLS at stalled forks and reducing mutagenesis.
https://buff.ly/3Xbgjxd

1 3

Pagès lab @pageslab.bsky.social · Dec 17

Recruiting a postdoc to work on our yeast project

1 3