ICYMI, the recordings of our #DevPres webinar on gene regulation are now available.
Check out the talks from @dev-journal.bsky.social PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social.
thenode.biologists.com/catch-up-on-...
#devbio 🎥

Check out the Perspective piece by our colleague @anzymiller.bsky.social and other fellows on the Pathway to Independence programme!

This exciting study led by @anzymiller.bsky.social is now published! NGN3 oscillations control the timing of differentiation during pancreas development through a fold-change sensitive gene regulatory motif. Congratulations to all authors!

A must read!

Thank you Samuel!

Overall, our exploration of HES1 and HES5 in the same cell suggests that a co-expressing hybrid state is enabled by oscillatory dynamics and synchronisation at single cell level.

Using in vivo data, we show that the fraction of neural progenitor cells that co-express HES1 and HES5 becomes reduced between E9.5 and E10.5. This is supported by analysis of existing transcriptomics data showing that progenitors are exiting the hybrid state during development.

In the coupled model, the resolution of the cross-repressive motif into a single dominant HES occurs through a change in cross-repression threshold and/or level; this suggests that a similar process could occur during development to give rise to separate HES1 and HES5 expression domains.

Using a computational model of HES protein repressing mRNA, we find that differences in protein stability give them distinct free-running oscillatory periods, but co-expression results in phase-locking, with slower HES5 entraining faster HES1.

Using in-vitro neural progenitor cultures and timelapse imaging, we show that most cells are in a hybrid HES1/HES5 state characterised by co-oscillation at a common 3-4h period. At the same time, a minority of progenitors show resolution of the hybrid state into one dominant HES.

In our latest study by @veronicabiga.bsky.social, we explore how the “Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif”:
www.biorxiv.org/content/10.1...

We're very excited to announce that our colleague @anzymiller.bsky.social is about to begin her @dev-journal.bsky.social Pathway to Independence journey! This will provide mentoring and support to emerging researchers in developmental biology and stem cells . journals.biologists.com/dev/pages/pi...

We are also highlighting John Gurdon, 2012 Nobel laureate in Physiology or Medicine and former Chair of the Board of Directors at @biologists.bsky.social, as an extraordinary biologist. #100biologists

We're excited to host two fantastic speakers at our next online @physicsoflifeuk.bsky.social ECR Seminar on Tuesday 15 April, 2–3 PM BST:
Tisma Milos and Thomas McLean
chaired by @veronicabiga.bsky.social

Please register below for the Zoom link:
lnkd.in/dSynrAe8

We are highlighting Kate Storey, who served as a Director at @biologists.bsky.social from 2007 to 2022 and co-founded the Company’s Workshop programme, as an extraordinary biologist. #100biologists

While we update our page- you can check out more on our website papalopululab.wordpress.com

We just joined Bluesky and we're hoping to connect with fellow scientists interested in quantitative and developmental biology! Follow us for future updates! Logo credit goes to @golgigraphics.bsky.social