Patricia
@patriciasch.bsky.social
Molecular biologist interested in RNA-Protein interactions.
She/Her, Sie/Ihr
She/Her, Sie/Ihr
Reposted by Patricia
New method drop:
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
June 2, 2025 at 10:30 AM
New method drop:
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
Reposted by Patricia
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Patricia
Spatial architecture of development and disease
go.nature.com/477Dmxs
#Review by Enikő Lázár & Joakim Lundeberg
Free to read here: rdcu.be/eJ9E4
go.nature.com/477Dmxs
#Review by Enikő Lázár & Joakim Lundeberg
Free to read here: rdcu.be/eJ9E4
Spatial architecture of development and disease - Nature Reviews Genetics
Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. The authors review spatially resolved molecular changes across diseases and discuss the potential of spatial multi-omics for clinical applications, including the recent impact of artificial intelligence.
go.nature.com
October 9, 2025 at 8:41 AM
Spatial architecture of development and disease
go.nature.com/477Dmxs
#Review by Enikő Lázár & Joakim Lundeberg
Free to read here: rdcu.be/eJ9E4
go.nature.com/477Dmxs
#Review by Enikő Lázár & Joakim Lundeberg
Free to read here: rdcu.be/eJ9E4