Patrick McArthur
@patrick-mcarthur.bsky.social
Just another guy passionate about medicine!
My interests:
translational science, research methodology, hardcore music, liberation movements, past/present/future of healthcare
My interests:
translational science, research methodology, hardcore music, liberation movements, past/present/future of healthcare
IIRC, the ROI of NIH research investment is second only to IRS funding
July 27, 2025 at 10:55 PM
IIRC, the ROI of NIH research investment is second only to IRS funding
Reposted by Patrick McArthur
Indirect rates are not determined by NIH. Instead, they are the product of elaborate negotiations between each institution and the “cognizant federal agency” according to an Office of Management and Budget document, Circular A-21.
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February 8, 2025 at 12:51 AM
Indirect rates are not determined by NIH. Instead, they are the product of elaborate negotiations between each institution and the “cognizant federal agency” according to an Office of Management and Budget document, Circular A-21.
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For more information (that is markedly less simplified but presented in a much more fun way), check out one of my favorite episodes of the best podcast around.
Or at least read the show notes found here: curiousclinicians.com/2021/09/01/e...
Or at least read the show notes found here: curiousclinicians.com/2021/09/01/e...
Episode 33: How does Sinemet’s name provide insights into why it was developed and its mechanism of action?
For this week’s episode, we discussed drug names. More specifically, we talked about how one drug’s name says a lot about its development and mechanism of action. The drug: Sinemet (carbidopa…
curiousclinicians.com
December 28, 2024 at 8:54 PM
For more information (that is markedly less simplified but presented in a much more fun way), check out one of my favorite episodes of the best podcast around.
Or at least read the show notes found here: curiousclinicians.com/2021/09/01/e...
Or at least read the show notes found here: curiousclinicians.com/2021/09/01/e...
Fun fact: With L-dopa alone, patients would have nausea and vomiting. The drug Sinemet (sin:without emesis:vomiting) was named for solving this problem!
Adding Carbidopa (an inhibitor of the enzyme that activates L-dopa) only blocks its action before the BBB!
Thanks, @curiousclinpod.bsky.social!
Adding Carbidopa (an inhibitor of the enzyme that activates L-dopa) only blocks its action before the BBB!
Thanks, @curiousclinpod.bsky.social!
December 28, 2024 at 8:48 PM
Fun fact: With L-dopa alone, patients would have nausea and vomiting. The drug Sinemet (sin:without emesis:vomiting) was named for solving this problem!
Adding Carbidopa (an inhibitor of the enzyme that activates L-dopa) only blocks its action before the BBB!
Thanks, @curiousclinpod.bsky.social!
Adding Carbidopa (an inhibitor of the enzyme that activates L-dopa) only blocks its action before the BBB!
Thanks, @curiousclinpod.bsky.social!
Mirrored pairs explain a lot, but chirality is hard!
In this 3D world, the reason you can't flip your left hand palm up to mirror your right hand is the exact same reason we have to separate L Dopa and R Dopa to make medicine that doesn't cause neutropenia!
In this 3D world, the reason you can't flip your left hand palm up to mirror your right hand is the exact same reason we have to separate L Dopa and R Dopa to make medicine that doesn't cause neutropenia!
December 28, 2024 at 8:36 PM
Mirrored pairs explain a lot, but chirality is hard!
In this 3D world, the reason you can't flip your left hand palm up to mirror your right hand is the exact same reason we have to separate L Dopa and R Dopa to make medicine that doesn't cause neutropenia!
In this 3D world, the reason you can't flip your left hand palm up to mirror your right hand is the exact same reason we have to separate L Dopa and R Dopa to make medicine that doesn't cause neutropenia!