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Dr. Patrick Hwu @patrickhwumd.bsky.social · 28d

It was a pleasure to share the latest on next-gen cell therapies @ufhealthcancer.bsky.social today.

Thank you for the opportunity to kick off your fall Grand Rounds. It’s always inspiring to connect with colleagues who share our drive to push the boundaries of discovery and care.

UF Health Cancer Center @ufhealthcancer.bsky.social · 28d

We had the honor of hosting @patrickhwumd.bsky.social president and CEO of @moffittnews.bsky.social, at UF today for an incredible talk on next-generation T-cell therapies for cancer. It was an inspiring and motivating way to kick off our fall Oncology Grand Rounds series. Thank you, Dr. Hwu!

Dr. Hwu and Dr. Licht pose with a photo with an award.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Aug 11

Had fun trying some new songs with @drdanarocks.bsky.social! What do you think of our take on the Chapell Roan megahit #PinkPonyClub?

#MusicMonday #DocsWhoRock #TheReMissions

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Dr. Patrick Hwu @patrickhwumd.bsky.social · May 24

🌟These findings may lead to vaccine and adoptive cell therapy strategies against pancreatic cancer.

🔗 Here's a link to the full study: lnkd.in/etf8fkf8

#Immunotherapy #PancreaticCancer #CancerResearch

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Dr. Patrick Hwu @patrickhwumd.bsky.social · May 24

➡️ In a recent study, investigators found that tumors make mistakes (translational errors) in the production of peptides that can lead to novel shared antigens on pancreatic cancers.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · May 24

➡️ This requires the identification of target peptides, called antigens, that are present in pancreatic cancers but not in normal tissues. While this can result from tumor DNA mutations, there is still a limited number of antigens capable of being recognized by T cells.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · May 24

#ScienceSaturday 🧵

❓ How can we target pancreatic cancer with T cells?

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Dr. Patrick Hwu @patrickhwumd.bsky.social · May 3

🌟 Since cancers increase with age, future work towards understanding the mechanisms underlying these observations may lead to new treatment strategies.

🔗 Here's a link to the full article via @nejm.org - www.nejm.org/doi/full/10....

#Immunology #Immunotherapy #CancerResearch

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Dr. Patrick Hwu @patrickhwumd.bsky.social · May 3

➡️ Analyzing nearly 50 thousand cancer patients, @oriolpich.bsky.social et al. found that patients whose tumors were infiltrated with CHIP-mutated immune cells had a worse prognosis, possibly due to increased inhibitory myeloid cells.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · May 3

#ScienceSaturday 🧵

❓ How does aging affect the immune cells infiltrating tumors?

➡️ As we age, our circulating blood and immune cells can develop mutations called clonal hematopoiesis of indeterminate potential (CHIP).

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Apr 15

🗣️ Share this with the women in your life! The @NCCN has shared updated screening guidelines for women with extremely dense breasts. Moffitt’s Dr. Bethany Niell explains the new guidelines and why they are important.

www.moffitt.org/endeavor/arc...

Screening Guidelines Updated for Women With ‘Extremely Dense’ Breasts

Recommendations now encourage supplemental breast MRIs for certain patients

www.moffitt.org

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Apr 11

Excited to be joined by biotech executives, entrepreneurs, investors and researchers today at #MoffittBoB to discuss the latest advances in cancer care. A big thank you to Florida Secretary of Commerce Alex Kelly for kicking off the event at our leadership breakfast.

@moffittnews.bsky.social

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Apr 1

🌟 Early findings suggest this approach could improve outcomes for patients who do not respond well to current immunotherapies. Personalized TIL could be an important tool in the fight against gastrointestinal cancers!

Here’s a link to the full study- www.nature.com/articles/s41591-025-03627-5

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Apr 1

➡️ In this study, published in Nature Medicine, Lowery, et al. found that expanding TILs that recognize patient-specific tumor mutations can enhance the immune response against cancer. When combined with anti-PD1, the response rate was 23 percent in patients with GI cancers.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Apr 1

📢 New landmark research out today on #TILTherapy for GI cancers

❓Can neoantigen-specific tumor-infiltrating lymphocytes (TILs) improve #immunotherapy for gastrointestinal cancers?

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 31

Happy #NationalDoctorsDay! Join me in recognizing all of our inspiring docs who make a difference in the lives of our patients every day @moffittnews.bsky.social! Photos from our Doctors’ Day lunch celebration! 🩺🥼

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 29

🌟 This study suggests that inhibiting MDK could be a valuable strategy to improve immunotherapy outcomes in melanoma!

🔗 Here’s a link to the full study: www.nature.com/articles/s43018-025-00929-y

@naturecancer.bsky.social

Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 29

➡️ Targeting MDK in preclinical models restored dendritic cell function, enhanced the activation of cytotoxic T cells, and improved antitumor immune responses.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 29

➡️ In this study, MDK was shown to induce immune suppression by altering dendritic cell function. This impaired the ability of the immune system to effectively target and eliminate melanoma cells, allowing the tumor to progress.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 29

#ScienceSaturday 🧵

➡️ Melanoma secretes a protein called midkine (MDK), which plays a key role in reprogramming dendritic cells in the tumor microenvironment.

❓ How can this impact immune responses?

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 26

Thank you to Lakeland Commissioner Stephanie Madden and other Polk County leaders for joining us this week to tour our brand-new Moffitt at SouthShore ambulatory center!

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Reposted by Dr. Patrick Hwu

Moffitt Cancer Center @moffittnews.bsky.social · Mar 7

Moffitt Cancer Center is proud to be the first standalone cancer center in the world to open a Nikon Center of Excellence! This prestigious achievement reflects our commitment to cutting-edge imaging technology and groundbreaking cancer research.

Read more: bit.ly/41L1R0L

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 1

🔗 Here’s a link to the full study- www.science.org/doi/10.1126/...

Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 1

🌟 This highlights the potential importance of B cells in antitumor immune responses and may indicate that B cell activation strategies should be studied in cancer patients.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 1

➡️ In a recent article by Ayana Ruffin, et al. dysfunctional (double negative) B cells were found to accumulate in patients with head and neck cancer and were associated with disease progression.

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Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 1

➡️ B cells, which produce antibodies, are important to prevent infections and are now being studied for their role in antitumor immune responses.

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