Paul Harrison
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paulfharrison.bsky.social
Paul Harrison
@paulfharrison.bsky.social
Bioinformatician at Monash University, Melbourne, Australia.

I also use mastodon: @[email protected]
https://mastodon.online/@pfh

My homepage is:
https://logarithmic.net/pfh/

On Twitter I was: @paulfharrison
A question: How do biologists learn experimental design? Any suggestions for good textbooks or notable people responsible for current practices?

(I recently failed to convince some collaborators doing an experiment about data-visualization of the importance of a positive control.)
February 3, 2026 at 10:15 PM
For example parquet is a high performance format, but writing was a bottleneck until I wrote to multiple files at once. The arrow library then makes it easy to read across multiple files at once.

Zarr is another format that seems to lean-in to this idea, but I don't have much experience with it.
December 29, 2025 at 2:28 AM
This is my simplified version which I use to illustrate different types of error bars:

logarithmic.net/2017/dance/
Dance of the CIs
logarithmic.net
December 7, 2025 at 9:07 PM
Love this type of thing. I particularly like repeatedly sampling Confidence Intervals as a teaching tool. There's a web app that goes with a book caled "The New Statistics" where they call this the "Dance of the CIs".

esci.thenewstatistics.com
esci-web Main Menu
esci.thenewstatistics.com
December 7, 2025 at 9:02 PM
I should also note Shiny's own version of this, ExtendedTask, similarly allows an app to remain responsive.

If inputs to an ExtendedTask change while it is running, the new computation is delayed until the current one finishes. This isn't ideal for my application.

shiny.posit.co/r/articles/i...
Shiny - Non-blocking operations
Shiny is a package that makes it easy to create interactive web apps using R and Python.
shiny.posit.co
November 29, 2025 at 9:31 PM
The splats can also be used as weights for local model fitting.
October 11, 2025 at 7:36 AM
*Grimes
August 3, 2025 at 5:28 AM
If you've ever wondered why medical research has so many Chesterton's Fences, or what it would actually take to "do your own research", this would be a good starting point. (The target audience of the book is doctors seeking to use published medical research.)
August 3, 2025 at 5:18 AM
I did get the AMS. Not quite sure what I'm doing with it. Maybe some interesting possibilities mixing soft and hard materials.

I've heard good things about marble PLA.
July 31, 2025 at 4:27 AM
with apologies to grugbrain.dev
The Grug Brained Developer
grugbrain.dev
July 11, 2025 at 6:50 AM