Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. Read more:
academic.oup.com/nar/article-...

Only just over a week left to apply for a postdoc position in our lab - if you are passionate about mtDNA maintenance and biochemistry or signaling, here is your chance!

Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...

Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share!
www.umu.se/en/work-with...

Our newest paper on mtDNA instability signaling by Gustavo Carvalho, Tran Nguyen and Bruno Repolês et al is out: Activating AMPK improves pathological phenotypes due to mtDNA depletion - Carvalho - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/full/10....

We are hiring!
We're looking for a Postdoctoral Researcher to explore the dynamics of human mitochondrial DNA replication at the single-molecule level.

Review the details below👇or visit borjaibarralab.com 💻