Pau Pascual
@paupascual.bsky.social
Love to see cells under a microscope | researcher @CRG.eu | @UPenn | 🏳️🌈
It is always delightful to read Juan Valcarcel's thoughts. A very well-deserved Carmen y Severo Ochoa awardee and, even better, a colleague from whom we all learn in seminars and talks. @crg.eu elpais.com/ciencia/2025...
Juan Valcárcel, biólogo molecular: “Cada uno de nosotros es una experiencia única. ¿Qué sentido tiene clonarnos?”
“Una forma de vida sintética no se ha producido aún, que yo sepa, pero no hay ninguna razón por la que no se pueda producir”, dice el científico, premio Carmen y Severo Ochoa de Investigación
elpais.com
December 20, 2025 at 12:44 PM
It is always delightful to read Juan Valcarcel's thoughts. A very well-deserved Carmen y Severo Ochoa awardee and, even better, a colleague from whom we all learn in seminars and talks. @crg.eu elpais.com/ciencia/2025...
Great news in these important days to fight #HIV infection that has taken the life of so many and caused stigma and discrimination.
Two studies suggest that T cells with stem-cell-like properties could work with antibody therapies to control HIV after a person stops taking antiviral pills
go.nature.com/441EK3M
go.nature.com/441EK3M
Antibodies and T cells join forces for sustained HIV remission
Two studies suggest that T cells with stem-cell-like properties could work with antibody therapies to control HIV after a person stops taking antiviral pills.
go.nature.com
December 4, 2025 at 10:18 PM
Great news in these important days to fight #HIV infection that has taken the life of so many and caused stigma and discrimination.
POM121 is one of the transmembrane nucleoporins that anchors the Nuclear Pore to the nuclear envelope. The Rodriguez-Bravo+labs identified a nuclear-soluble pool of POM121 that enhances the aggressiveness of prostate cancer, offering new therapeutic opportunities for this disease. shorturl.at/Z2Ked
Off-pore Nucleoporin sPOM121 Transcriptionally Propels β-Catenin–driven Tumor Progression and Immune Escape in Prostate Cancer
Transcriptional reprogramming, mediated by off-pore, nucleoplasm-localized sPOM121, leads to therapy resistance and immune evasion and represents a vulnerability to β-catenin inhibition in prostate ca...
aacrjournals.org
November 4, 2025 at 10:47 AM
POM121 is one of the transmembrane nucleoporins that anchors the Nuclear Pore to the nuclear envelope. The Rodriguez-Bravo+labs identified a nuclear-soluble pool of POM121 that enhances the aggressiveness of prostate cancer, offering new therapeutic opportunities for this disease. shorturl.at/Z2Ked
Reposted by Pau Pascual
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
October 23, 2025 at 7:56 AM
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
Really cool read - 'New generation of cancer-preventing vaccines could wipe out tumors before they form | Science | AAAS' www.science.org/content/arti...
New generation of cancer-preventing vaccines could wipe out tumors before they form
Shots enter early clinical trials for healthy people at high risk for disease
www.science.org
September 28, 2025 at 10:37 PM
Really cool read - 'New generation of cancer-preventing vaccines could wipe out tumors before they form | Science | AAAS' www.science.org/content/arti...
Reposted by Pau Pascual
Whitehead Institute honors the life and legacy of Nobel Laureate David Baltimore (1938–2025), its Founding Director and a globally revered scientific leader. 1/4
lnkd.in/eUKd4zxh
lnkd.in/eUKd4zxh
September 8, 2025 at 7:40 PM
Whitehead Institute honors the life and legacy of Nobel Laureate David Baltimore (1938–2025), its Founding Director and a globally revered scientific leader. 1/4
lnkd.in/eUKd4zxh
lnkd.in/eUKd4zxh
Great news, providing access to CRISPR therapy for rare diseases in children is giving hope to many families
chanzuckerberg.com/newsroom/cen...
chanzuckerberg.com/newsroom/cen...
Advancing Cures for Rare Diseases
With the launch of the new center, we're one step closer to making personalized CRISPR cures a reality for children born with rare genetic diseases.
chanzuckerberg.com
July 9, 2025 at 8:26 PM
Great news, providing access to CRISPR therapy for rare diseases in children is giving hope to many families
chanzuckerberg.com/newsroom/cen...
chanzuckerberg.com/newsroom/cen...
How are some enhancers able to regulate genes over megabase distances when they usually act in genes over kilobase distances? This is about a cis-element that helps enhancers to increase substantially their genomic interaction capacity.. Cool! www.nature.com/articles/s41...
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 6, 2025 at 9:56 PM
How are some enhancers able to regulate genes over megabase distances when they usually act in genes over kilobase distances? This is about a cis-element that helps enhancers to increase substantially their genomic interaction capacity.. Cool! www.nature.com/articles/s41...
Reposted by Pau Pascual
Introducing Arc Institute’s first virtual cell model: STATE
June 23, 2025 at 5:28 PM
Introducing Arc Institute’s first virtual cell model: STATE
Reposted by Pau Pascual
💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜
El 8-M de las científicas: miles de mujeres se vuelcan para despertar vocaciones en la niñas
Un movimiento imparable ha arrancado con fuerza: es el sigiloso 8-M de las científicas. Mujeres determinadas a enseñar a las chicas que pueden ser profesionales capaces
www.lavanguardia.com
February 11, 2025 at 8:42 AM
💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜
Today is #WorldCancerDay, a time to support those impacted, honor the memories of loved ones we've lost, and reflect on the important work we, as scientists, do.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
February 4, 2025 at 10:33 PM
Today is #WorldCancerDay, a time to support those impacted, honor the memories of loved ones we've lost, and reflect on the important work we, as scientists, do.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity.
This is such a step forward! Kudos to the authors. KRAS is mutated in around 25% of cancers and was considered “undruggable”, being this a good example of how the drug discovery field is being changed quickly with new computing tools and power. Hopefully the impact to patients arrives also soon! 🚀
Excited to share our latest work, published this morning in Nature Biotechnology! 🎉 We developed a hybrid quantum computing-enhanced generative model to design KRAS inhibitors. Check it out here: rdcu.be/d68Fs.
Some fascinating insights along the way:
Some fascinating insights along the way:
January 26, 2025 at 8:22 PM
This is such a step forward! Kudos to the authors. KRAS is mutated in around 25% of cancers and was considered “undruggable”, being this a good example of how the drug discovery field is being changed quickly with new computing tools and power. Hopefully the impact to patients arrives also soon! 🚀
