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Pau Clavell-Revelles @pclavell.bsky.social · May 30

I am so happy to learn that I won the Early Career Award for an outstanding presentation at the ESHG!!
Thanks to @melelab.bsky.social, @guigolab.bsky.social and to my awesome colleagues that also attended the conference for their support @rubenchazarra.bsky.social @ramirezjmiguel.bsky.social

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Pau Clavell-Revelles @pclavell.bsky.social · May 30

It's been an absolute pleasure to present my work on long-read transcriptomics in front of such a big audience at the European Conference of Human Genetics @eshg.bsky.social in Milano.
The feedback and the discussion were extremely interesting and useful!

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Reposted by Pau Clavell-Revelles

npujol.bsky.social @npujol.bsky.social · May 27

so well deserved! congratulations!!! @pclavell.bsky.social @melelab.bsky.social 🚀⭐️💫

European Society of Human Genetics @eshg.bsky.social · May 27

ESHG2025# Early Career awards:
For outstanding science presented at the conference

- Allison Newman, Exeter, UK
- Hristiana Lyubenova, Berlin, Germany
- Robin J. Hofmeister, Lausanne, Switzerland
- Pau Clavell-Revelles, Barcelona, Spain

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Reposted by Pau Clavell-Revelles

Winona Oliveros @oliveroswinona.bsky.social · May 5

Excited to share our new preprint: The impact of sex, age, and genetic ancestry on DNA methylation across tissues. Briefly, we explored how sex, age, and genetic ancestry shape DNA methylation across tissues and individuals. Want to know a bit more? Follow this “bluetorial”!
doi.org/10.1101/2025...

The impact of sex, age, and genetic ancestry on DNA methylation across tissues

Background: Understanding the consequences of individual DNA methylation variation is crucial for the study of human biology and disease. However, the collective impact of demographic traits on DNA me...

www.biorxiv.org

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Reposted by Pau Clavell-Revelles

Melé Lab @melelab.bsky.social · May 23

📢Menopause affects half the population — yet it's been one of the most overlooked areas in aging research.
We found that aging in the female reproductive system unfolds in unexpected, organ-specific ways. 🔗 www.biorxiv.org/content/10.1...
1/8🧵

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Pau Clavell-Revelles @pclavell.bsky.social · Mar 21

🥰

Reposted by Pau Clavell-Revelles

Marta Melé @martamele.bsky.social · Mar 20

This has been a fantastic collaboration with @guigolab.bsky.social and led by @pclavell.bsky.social & @fairlie.bsky.social where we show something we suspected for some time: human gene annotations are European-biased, read this thread to know more about this work @bsc-cns.bsky.social @crg.eu

Melé Lab @melelab.bsky.social · Mar 20

Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️

WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!

🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!

Don't miss this thread🧵⬇️
1/13

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

www.biorxiv.org

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Pau Clavell-Revelles @pclavell.bsky.social · Mar 20

Thank you Sam!🥰

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Pau Clavell-Revelles @pclavell.bsky.social · Mar 20

Finally, thanks to @oliveroswinona.bsky.social and the whole @melelab.bsky.social and GENCODE team at @guigolab.bsky.social that contributed to my training to get all this work done!

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Pau Clavell-Revelles @pclavell.bsky.social · Mar 20

Thanks to @fdegalez.bsky.social for his effectiveness and decisive findings on the personal genomes sections and his endless will to contribute to this amazing project!🤩
3️⃣

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Pau Clavell-Revelles @pclavell.bsky.social · Mar 20

Also it has been amazingly engaging to be supervised by two great group leaders at once @martamele.bsky.social @rodericguigo.bsky.social throughout the project. Thanks a lot!
2️⃣

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Pau Clavell-Revelles @pclavell.bsky.social · Mar 20

One of the best experiences of this project is to get to do science in a team, where ideas and deeper insights truly make the difference! Most of it was a duo journey with @fairlie.bsky.social whose work, expertise and support has been pivotal to get such a paper in so "little" time. Thanks a lot!
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Melé Lab @melelab.bsky.social · Mar 20

Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️

WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!

🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!

Don't miss this thread🧵⬇️
1/13

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

www.biorxiv.org

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Pau Clavell-Revelles @pclavell.bsky.social · Mar 20

I never thought that I would wear again the lab coat 🥼 but I did it to sequence RNA with @nanoporetech.com at @guigolab.bsky.social . Thanks to @scarbonells.bsky.social , Carme and Zighi for their great teachings and patience in the wetlab. They definitely have solutions for everything!

Melé Lab @melelab.bsky.social · Mar 20

Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️

WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!

🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!

Don't miss this thread🧵⬇️
1/13

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

www.biorxiv.org

2 5

Pau Clavell-Revelles @pclavell.bsky.social · Mar 20

So excited about showing our work (@fairlie.bsky.social) to the world!!

Do not miss this thread with the main findings of our Long-Read Transcriptomics project on a Population-Diverse Cohort🤩

Melé Lab @melelab.bsky.social · Mar 20

Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️

WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!

🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!

Don't miss this thread🧵⬇️
1/13

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

www.biorxiv.org

4

Reposted by Pau Clavell-Revelles

Melé Lab @melelab.bsky.social · Mar 20

Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️

WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!

🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!

Don't miss this thread🧵⬇️
1/13

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

www.biorxiv.org

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Reposted by Pau Clavell-Revelles

Winona Oliveros @oliveroswinona.bsky.social · Mar 18

I am SO EXCITED about this! An incredible amount of work from two brilliant people. I believe a bluetorial is on the way, stay tuned! 💜 @fairlie.bsky.social @pclavell.bsky.social @melelab.bsky.social @guigolab.bsky.social

bioRxiv Genomics @biorxiv-genomic.bsky.social · Mar 17

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation https://www.biorxiv.org/content/10.1101/2025.03.14.643250v1

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Reposted by Pau Clavell-Revelles

bioRxiv Genomics @biorxiv-genomic.bsky.social · Mar 17

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation https://www.biorxiv.org/content/10.1101/2025.03.14.643250v1

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Pau Clavell-Revelles @pclavell.bsky.social · Dec 13

Excited to present my latest results from my PhD project about long-read transcriptomics at Jornades de Bioinformàtica i Genòmica by @scb.iec.cat
Stay tuned as in the following months @fairlie.bsky.social and I will be unveiling an exciting discovery from a human population-diverse perspective!

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