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Reposted by Winona Oliveros

Beatriz Urda @beatrizurda.bsky.social · Sep 2

1/ Everything that could go wrong in paper publishing… did.
A story of patience, absurdity, and persistence 🌀 <1min

From Alfonso Valencia’s lab and a very stubborn PhD student (me).

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Reposted by Winona Oliveros

Guigó Lab @guigolab.bsky.social · Jul 28

🚨 We are hiring a Postdoc @crg.eu! 🧬
 Within the EU-funded #PrecisionTox project. We are developing computational methods to predict toxicity by integrating RNA-seq data from humans and model species 🪱🪰🐸🐠. The project will help replace animal testing.

🔗 Apply now: recruitment.crg.eu/content/jobs...

Post-Doctoral Researcher for Precision Tox | CRG Online Recruitment Portal

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

recruitment.crg.eu

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BSC-CNS @bsc-cns.bsky.social · Jun 5

🚬The molecular impact of cigarette smoking resembles aging across tissues

⭕This is the 1st comprehensive, multi-tissue analysis to show that smoking doesn’t just harm specific organs like the lungs 🫁

📄By BSC & Universidade do Porto researchers, published in Genome Medicine: bsc.es/Zt2

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Reposted by Winona Oliveros

The Guardian @theguardian.com · Jun 5

Breakthrough in search for HIV cure leaves researchers ‘overwhelmed’

Exclusive: Melbourne team demonstrates way to make the virus visible within white blood cells, paving the way to fully clear it from the body A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells. The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle. Continue reading...

www.theguardian.com

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Winona Oliveros @oliveroswinona.bsky.social · Jun 4

This work highlights the widespread and multi-layered impact of smoking on biological aging and reinforces the value of integrative, system-level approaches to public health research.

It’s been an immense pleasure to collaborate on this project with such a talented team!

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Winona Oliveros @oliveroswinona.bsky.social · Jun 4

In this study, we show how tobacco use accelerates aging across nearly all tissues in the human body; not just through histological changes, but also at the levels of DNA methylation and gene expression.

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Winona Oliveros @oliveroswinona.bsky.social · Jun 4

🧬 I’m thrilled to share our latest publication in Genome Medicine, led by the brilliant @ramirezjmiguel.bsky.social :

“The molecular impact of cigarette smoking resembles aging across tissues”

👉 genomemedicine.biomedcentral.com/articles/10....

The molecular impact of cigarette smoking resembles aging across tissues - Genome Medicine

Background Tobacco smoke is the main cause of preventable mortality worldwide. Smoking increases the risk of developing many diseases and has been proposed as an aging accelerator. Yet, the molecular ...

genomemedicine.biomedcentral.com

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npujol.bsky.social @npujol.bsky.social · May 27

so well deserved! congratulations!!! @pclavell.bsky.social @melelab.bsky.social 🚀⭐️💫

European Society of Human Genetics @eshg.bsky.social · May 27

ESHG2025# Early Career awards:
For outstanding science presented at the conference

- Allison Newman, Exeter, UK
- Hristiana Lyubenova, Berlin, Germany
- Robin J. Hofmeister, Lausanne, Switzerland
- Pau Clavell-Revelles, Barcelona, Spain

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Pau Clavell-Revelles @pclavell.bsky.social · May 30

It's been an absolute pleasure to present my work on long-read transcriptomics in front of such a big audience at the European Conference of Human Genetics @eshg.bsky.social in Milano.
The feedback and the discussion were extremely interesting and useful!

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Pau Clavell-Revelles @pclavell.bsky.social · May 30

I am so happy to learn that I won the Early Career Award for an outstanding presentation at the ESHG!!
Thanks to @melelab.bsky.social, @guigolab.bsky.social and to my awesome colleagues that also attended the conference for their support @rubenchazarra.bsky.social @ramirezjmiguel.bsky.social

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Tuuli Lappalainen @tuuliel.bsky.social · May 6

Our new contribution to the quest to find causal GWAS genes! Sam Ghatan from my lab at @nygenome.org led a systematic comparison of eQTLs and CRISPRi+scRNA-seq screens. TL;DR: they provide highly complementary insights, with ortogonal pros and cons. 🧵👇
www.biorxiv.org/content/10.1...

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Winona Oliveros @oliveroswinona.bsky.social · May 8

I’m so sorry to hear this, John. Keeping you and your family in my thoughts. When I faced something similar, what kept me going was thinking about how proud they are of what we do. Just spending time with them and doing your best really matters. You will get through this, I’m sure of it!

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Winona Oliveros @oliveroswinona.bsky.social · May 5

Our work provides a detailed view of epigenetic variation under healthy conditions, a useful baseline for future epigenetic studies.

Big thanks to my amazing co-author @ramirezjmiguel.bsky.social, the best partner I could ever ask for! And to the best PhD mentor @martamele.bsky.social!

The impact of sex, age, and genetic ancestry on DNA methylation across tissues

Background: Understanding the consequences of individual DNA methylation variation is crucial for the study of human biology and disease. However, the collective impact of demographic traits on DNA me...

www.biorxiv.org

Winona Oliveros @oliveroswinona.bsky.social · May 5

Aging & PRC:
Aging increases DNA methylation at PRC target sites across most tissues, consistent with the literature. But interestingly: not in the gonads!
Why gonads behave differently is still an open question.

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Winona Oliveros @oliveroswinona.bsky.social · May 5

Focusing on the sex differences, we found:
The female genome is hypermethylated across tissues.
Why? We hypothesize that it is likely due to the continuous activity of the Polycomb Repressive Complex (PRC), a key chromatin regulator in the X chromosome inactivation.

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Winona Oliveros @oliveroswinona.bsky.social · May 5

But does DNA methylation mediate gene expression changes?
Surprisingly, less than 10% of the expression variation linked to sex, age, or ancestry is explained by methylation, with ancestry showing the highest mediation.

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Winona Oliveros @oliveroswinona.bsky.social · May 5

Which factors matter most?
Genetic ancestry and age have stronger effects on methylation than sex.
But: (1) Age changes are widespread but modest. (2) Ancestry changes are more localized and often under genetic control.

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Winona Oliveros @oliveroswinona.bsky.social · May 5

First: DNA methylation varies more than gene expression across individuals.
This suggests methylation captures broader inter-individual variability, possibly including environmental and genetic effects.

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Winona Oliveros @oliveroswinona.bsky.social · May 5

Excited to share our new preprint: The impact of sex, age, and genetic ancestry on DNA methylation across tissues. Briefly, we explored how sex, age, and genetic ancestry shape DNA methylation across tissues and individuals. Want to know a bit more? Follow this “bluetorial”!
doi.org/10.1101/2025...

The impact of sex, age, and genetic ancestry on DNA methylation across tissues

Background: Understanding the consequences of individual DNA methylation variation is crucial for the study of human biology and disease. However, the collective impact of demographic traits on DNA me...

www.biorxiv.org

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Reposted by Winona Oliveros

Centre de Regulació Genòmica (CRG) @crg.eu · Apr 24

It's a beautiful spring day in Barcelona. Sunshine welcoming all our guests for the first day of the CRG's annual symposium! This year's theme is all about the mechanisms of gene expression.

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Viki Male @vikilovesfacs.bsky.social · Apr 24

👶🏼 Many #vaccines are not effective in newborns. So how do we protect them from infectious disease?

🤰🏽 By vaccination in #pregnancy!

Here we review…

💉 Established campaigns vs whooping cough, flu, COVID

💡 New approaches to RSV, GBS

🌈 Future challenges, opportunities

#ReproSky #ImmunoSky #IDSky

Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology

In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and t...

www.nature.com

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Eric Topol @erictopol.bsky.social · Apr 23

New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM

Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...

www.nejm.org

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Kristian G. Andersen @kgandersen.bsky.social · Apr 15

This is what scientific leadership and courage looks like:

www.harvard.edu

Harvard University

Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.

www.harvard.edu

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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · Apr 14

We called out Harvard in the past for inaction. So now we are happy to speak out with praise.

This is a major step forward.

It’s not just a lack of capitulation. It’s an aggressive effort leaning into public comms — exactly what is needed. Bravo to Harvard 👏

Malinda Lo @malindalo.bsky.social · Apr 14

Harvard redid its whole homepage to push back against the administration’s demands. I mean, this is just a website but I think it’s kind of a great PR move: www.harvard.edu

Harvard University

Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.

www.harvard.edu

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BSC-CNS @bsc-cns.bsky.social · Apr 14

🎆 Congratulations to @elisamasber.bsky.social, from the Aerosols, Dust and Climate group, on the successful defence of her #PhD thesis!

🙌We wish you all the best, Elisa!

#BSCTalent

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