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Reposted by Tuuli Lappalainen

Ewan Birney @ewanbirney.bsky.social · 1d

Some thoughts on the blossoming of genomic medicine stimulated by the excellent @ga4gh.org meeting in lovely Uppsala Sweden. www.linkedin.com/pulse/though...

Thoughts from Uppsala - Genomic Medicine blossoming

I have had a wonderful three days in Uppsala Sweden, at the Global Alliance for Genomics and Health plenary hosted locally by the generous SciLifeLab . It was a meeting of course focused on the standa...

www.linkedin.com

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Reposted by Tuuli Lappalainen

Rob Patro @robp.bsky.social · 1d

Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬

Rob Patro @robp.bsky.social · 2d

And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!

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Tuuli Lappalainen @tuuliel.bsky.social · 1d

This is a landmark paper and resource describing circulating proteome variation in human diseases. Congrats to many colleagues in 🇸🇪 @proteinatlas.bsky.social @scilifelab.se !

Jochen Schwenk @jochwenk.bsky.social · 1d

🚨 A new open-access resource of @proteinatlas.bsky.social

A human pan-disease🩸 atlas of the circulating proteome

👉 www.proteinatlas.org/humanproteom...
📖 www.science.org/doi/10.1126/...

🤩 @buenoalvez.bsky.social and many more!

@kawresearch.bsky.social
@scilifelab.se
@kthuniversity.bsky.social

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Tuuli Lappalainen @tuuliel.bsky.social · 1d

Jep. Oman kokemuksen mukaan (🇸🇪🇺🇸🇪🇺 jne) biotieteissä ainakaan näitä ei todellakaan lueta sillä silmällä, osaako hakija asetella sukupuolentutkimuksen termistön kauniiseen järjestykseen, vaan ihan järki kädessä. Hyvin harvassa on hakemukset, jotka saa näistä lausunnoista miinusta.

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Tuuli Lappalainen @tuuliel.bsky.social · 1d

On helpompi laittaa kaikille sama vaatimus; jos ei ole tasa-arvonäkökulmia niin sitten lausunto on lyhyt, versus jonkinlainen etukäteisarviointi sille, missä hakemuksissa lausunto on tarpeen. Ehkä rahoittajat voisi avata logiikkaa enemmän turhan stressin (tai woke-valituksen) ehkäisemiseksi.

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Tuuli Lappalainen @tuuliel.bsky.social · 1d

En tiedä SA:sta, mutta muualla nämä eivät yleensä vaikuta pisteytykseen ellei siellä ole jotain aivan karseaa, ja aivan erityisen ansiokkaat projektit/tutkijat saavat tilaisuuden tuoda tämän esille. Mutta yleensä pointtina on pakottaa kaikki tutkijat miettimään edes hetki tasa-arvonäkökulmaa.

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Tuuli Lappalainen @tuuliel.bsky.social · 1d

Nämä ovat totta yhtä aikaa: 1) tällaisten lausuntojen kirjoittaminen tuntuu usein aika turhalta, 2) ei ole pahitteeksi, että tutkijoita pakotetaan harvakseltaan miettimään, millaisia tasa-arvonäkökulmia projektissa tai tutkimustiimissä on, ja miten niitä on huomioitu.

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Reposted by Tuuli Lappalainen

Inigo Martincorena @imartincorena.bsky.social · 1d

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Inigo Martincorena @imartincorena.bsky.social · 2d

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

www.nature.com

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Reposted by Tuuli Lappalainen

Andrew Iwaniuk @evoneuro.bsky.social · 1d

As I tell my students, if you arrived at a simple answer in biology you have done one of two things: arrived at the wrong answer or asked the wrong question

Claus Wilke @clauswilke.com · 3d

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...

We still can’t predict much of anything in biology

Biology is hard. Yes, even for AI.

blog.genesmindsmachines.com

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Reposted by Tuuli Lappalainen

👻madeline boOoOoOodent👻 @oldenoughtosay.com · 2d

the answer to the trolley problem is not to pick who to sacrifice, it’s to dismantle the system that led to an unsafe trolley crossing.

if any part of your morality strategy involves picking a group to let die on a hill, throw the entire strategy out. it’s wrong.

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Reposted by Tuuli Lappalainen

Jo Wolff @jowolff.bsky.social · 2d

This was not a sample of academics.

YouGov @yougov.co.uk · 2d

How many browsing tabs do you typically have open?*

1: 6%
2-5: 54%
6-10: 14%
11-20: 8%
21-30: 2%
More than 30: 3%

*across all windows, on desktop/laptop

yougov.co.uk/topics/techn...

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Tuuli Lappalainen @tuuliel.bsky.social · 2d

We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...

Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center

Find a career with New York Genome Center

jobs.silkroad.com

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Reposted by Tuuli Lappalainen

Jeremy Berg @jeremymberg.bsky.social · 4d

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

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jeremymberg.github.io

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Reposted by Tuuli Lappalainen

Jonathan Pritchard @jkpritch.bsky.social · 4d

I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.

I did this last year and it was great to meet a whole bunch of new people, at all career stages!

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Reposted by Tuuli Lappalainen

Bart Deplancke @bartdeplancke.bsky.social · 5d

🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China

Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics

This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.

www.nature.com

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Reposted by Tuuli Lappalainen

Senator Scott Wiener @scottwiener.bsky.social · 8d

The regime’s new proposed “compact” with universities — conditioning federal funds on giving up academic freedom & free speech & throwing trans & non-US students under the bus — is unconstitutional.

Every university must reject it. It’s classic hang together or hang separately.

Opinion | Trump’s ‘Compact’ With Universities Is Just Extortion

www.nytimes.com

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Reposted by Tuuli Lappalainen

Patrick Goymer @patrickgoymer.bsky.social · 9d

As we mourn Jane Goodall, this @nature.com article explores three ways in which she changed science:

1. Altering the way we view both other primates and ourselves
2. Inspiring generations of women scientists
3. Communicating science in a way that engaged the public

www.nature.com/articles/d41...

Jane Goodall’s legacy: three ways she changed science

The primatologist challenged what it meant to be a scientist.

www.nature.com

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Reposted by Tuuli Lappalainen

Erin Sikorsky @erinsikorsky.bsky.social · 9d

Oof, one of my heroes.

Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91

www.nytimes.com

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Reposted by Tuuli Lappalainen

Max Kozlov @maxkozlov.bsky.social · 10d

Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.

“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.

www.nature.com/articles/d41...

NIH races to spend its 2025 grant money — but fewer projects win funding

Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.

www.nature.com

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Reposted by Tuuli Lappalainen

Jake Grumbach @jakemgrumbach.bsky.social · 10d

Since the Ezra & Ta-Nehisi discussion is still happening: the main point I think most are missing is that Klein is saying the role of the journalist-intellectual is to do strategic politics, whereas Coates says the role of the journalist-intellectual is to tell the truth

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Reposted by Tuuli Lappalainen

Andrea Ganna @andganna.bsky.social · 11d

Why it matters? progression genetics is more relevant drug targets + clinical care.

👉 Solutions:
• Build larger, harmonized cohorts & refined progression phenotypes
• Use proxy phenotypes from general population

Read: www.nature.com/articles/s41...

Limited overlap between genetic effects on disease susceptibility and disease survival - Nature Genetics

Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

www.nature.com

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Reposted by Tuuli Lappalainen

Nature Genetics @natgenet.nature.com · 11d

📢OUT TODAY @natgenet.nature.com

📰Limited overlap between genetic effects on disease susceptibility and disease survival.

By Zhiyu Yang, Nina Mars, Andrea Ganna and colleagues.

⬇️

www.nature.com/articles/s41...

Limited overlap between genetic effects on disease susceptibility and disease survival - Nature Genetics

Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

www.nature.com

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Reposted by Tuuli Lappalainen

Eric Topol @erictopol.bsky.social · 11d

A randomized trial of patients with advanced cancer who had genomically matched treatment vs standard of care showed substantial outcome improvement for the former
www.nature.com/articles/s41...

Genomically matched therapy in advanced solid tumors: the randomized phase 2 ROME trial - Nature Medicine

In the proof-of-concept phase 2 ROME trial, comprehensive genomic profiling followed by molecular tumor board evaluation and randomization of patients with metastatic solid cancer to receive personalized therapy or standard of care led to a significantly higher objective response rate and longer progression-free survival in patients who received personalized therapy.

www.nature.com

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Tuuli Lappalainen @tuuliel.bsky.social · 12d

Check out Lemminkäinen in the Finnish mythology: en.wikipedia.org/wiki/Lemmink...

Lemminkäinen - Wikipedia

en.wikipedia.org

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Tuuli Lappalainen @tuuliel.bsky.social · 15d

Same here, but this was me moving to a new city... This happened 12 years ago and since then I’ve checked a bag maybe 5 times.

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