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IPNA Pediatric Nephrology @ped-neph.bsky.social · 9h

Renal hypodysplasia (RHD) is a common & severe form of congenital anomalies of the kidney and urinary tract, often leading to CKD in children. Read this Original Article on characteristics of RHD in children: insights from a 10-yr single-center cohort.
link.springer.com/article/10.1...

Clinical and prognostic characteristics of renal hypodysplasia in children: insights from a 10-year single-center cohort

IPNA Pediatric Nephrology @ped-neph.bsky.social · 10h

Thrombotic occlusion of permanent double lumen catheters (PDLC) in hemodialysis has traditionally been treated with urokinase (UK). Read this Original Article comparing the efficacy of alteplase & UK in pharmacomechanical thrombolysis of PDLC in children.
link.springer.com/article/10.1...

Comparative efficacy of alteplase and urokinase in pharmacomechanical thrombolysis of permanent double lumen hemodialysis catheters in children

IPNA Pediatric Nephrology @ped-neph.bsky.social · 1d

Emphysematous pyelonephritis (EPN) is a critical & life-threatening necrotizing UTI, & is extremely rare in children. Read these Clinical Insights into a case of concurrent EPN & proteinaceous calculi w/recurrent Escherichia coli UTI. Open Access.
link.springer.com/article/10.1...

Emphysematous pyelonephritis and infection-related calculi

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 1d

The concept of optimal dialysis is derived from the recognition that dialytic care involves more than just providing adequate clearance. Read this Editorial Commentary that asks if home is best when it comes to pediatric hemodialysis.
link.springer.com/article/10.1...

Is home best when it comes to pediatric hemodialysis?

IPNA Pediatric Nephrology @ped-neph.bsky.social · 2d

Nephrotic syndrome (NS) is a common pediatric kidney disorder characterized by proteinuria, hypoalbuminemia, & edema. Read this Original Article on urinary leukotriene E4 for predicting steroid sensitivity in children w/NS. Open Access.
link.springer.com/article/10.1...

Urinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 5d

Urinary extravasation (UE) in patients w/PUV, in the form of urinomas or urinary ascites, is thought to represent a pop-off mechanism. Read this Original Article on the impact of UE in PUV: clinical implications of urinomas & ascites on kidney function.
link.springer.com/article/10.1...

Impact of urinary extravasation in posterior urethral valves: clinical implications of urinomas and ascites on kidney function

IPNA Pediatric Nephrology @ped-neph.bsky.social · 6d

VUR is a pediatric urological condition associated w/kidney scarring, which can lead to hypertension, proteinuria & CKD. Read this Original Article on urinary periostin as a novel non-invasive biomarker for kidney scarring in pediatric VUR patients.
link.springer.com/article/10.1...

Urinary periostin as a novel non-invasive biomarker for kidney scarring in pediatric vesicoureteral reflux patients

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 6d

IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide. Identifying prognostic markers is crucial for early intervention & long-term mgmt. Read this Review of new prognostic markers for IgAN in children.
link.springer.com/article/10.1...

New prognostic markers for IgA nephropathy in children

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 7d

Aquaporins (AQPs) are proteins that transport water molecules across membranes. Read this Original Article on the correlation between polymorphisms of the AQP-1 gene & peritoneal function in children on chronic peritoneal dialysis.
link.springer.com/article/10.1...

Correlation between polymorphisms of the aquaporin-1 gene and peritoneal function in children on chronic peritoneal dialysis

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 7d

Patients w/kidney failure require dialysis or kidney transplantation. Transplantation is often not possible due to a shortage of donor organs. Read this Review of xenotransplantation & its application to pediatric kidney disease. Free access this month.
bit.ly/4nxY1BG

Recent progress in xenotransplantation and its application to pediatric kidney disease

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 12d

Measures of early postnatal fluid balance may be associated w/severe intraventricular hemorrhage (sIVH) &/or death in extremely preterm infants in the first postnatal week. Read this Original Article for more. Open Access.
link.springer.com/article/10.1...

Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 12d

MIRAGE syndrome is a rare multisystem disorder caused by gain-on-function SAMD9 variants. Read these Clinical Insights into a 1-yr-old boy w/MIRAGE syndrome & nephrotic syndrome, whose kidney histopathology revealed membranous nephropathy.
link.springer.com/article/10.1...

A 1-year-old boy with MIRAGE syndrome and nephrotic syndrome, whose kidney histopathology revealed membranous nephropathy-like findings: a case report

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 13d

Read this Editorial Commentary on how we can make novel treatments of glomerular diseases available for children as early & safely as possible. Includes a historical perspective, differences between glomerular diseases, & a discussion.
link.springer.com/article/10.1...

How can we make novel treatments of glomerular diseases available for children as early and safely as possible?

IPNA Pediatric Nephrology @ped-neph.bsky.social · 13d

Native kidney biopsy is an important diagnostic procedure in pediatric nephrology. Read this Original Article on adequacy & safety of pediatric native kidney biopsy using 16- & 18-gauge needles.
link.springer.com/article/10.1...

Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 14d

Accurate glomerular filtration rate estimation (eGFR) is essential for managing pediatric kidney transplant recipients. Read this Original Article on comparing different equations for eGFR in pediatric kidney transplant recipients. Open Access.
link.springer.com/article/10.1...

Comparison of different equations for estimating the glomerular filtration rate in pediatric kidney transplant recipients

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 14d

Pediatric CKD causes significantly impaired health-related quality of life (hrQOL) & caregiver burden. Read this Original Article on hrQOL, mental health, & caregiver burden in children w/autosomal recessive polycystic kidney disease. Open Access.
link.springer.com/article/10.1...

Health-related quality of life, mental health and caregiver burden in children with autosomal recessive polycystic kidney disease

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 15d

Idiopathic nephrotic syndrome (INS) is a significant kidney disorder in pediatrics. Read this Original Article on macrophage migration inhibitory factor & angiopoietin-like protein 4 as markers for steroid response in children w/INS. Open Access.
link.springer.com/article/10.1...

Macrophage migration inhibitory factor and angiopoietin-like protein 4 as markers for steroid response in children with idiopathic nephrotic syndrome

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 16d

AI is a transformative force in pediatric nephrology, enabling improvements in diagnostic accuracy & therapeutic precision. Read this Review of AI-powered insights in pediatric nephrology: current applications & future opportunities. Open Access.
link.springer.com/article/10.1...

AI-powered insights in pediatric nephrology: current applications and future opportunities

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 19d

Read this Original Article on progression of the eGFR in asphyxiated neonates undergoing therapeutic hypothermia during the first 10 days of life. Part of the Topical Collection Advances in Neonatal Nephrology. Open Access.
link.springer.com/article/10.1...

Progression of the estimated glomerular filtration rate in asphyxiated neonates undergoing therapeutic hypothermia during the first 10 days of life

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 20d

In addition to acute morbidity & mortality, AKI is associated w/development of CKD & other long-term sequelae. Read this Editorial Commentary on assessing Major Adverse Kidney Events (MAKE) in children < 2 years.
link.springer.com/article/10.1...

Special considerations for assessing Major Adverse Kidney Events (MAKE) in children < 2 years of age

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 21d

Membranous-like glomerulopathy w/masked IgG-kappa deposits is rare & occurs primarily among young females w/previously diagnosed autoimmune diseases. Read these Clinical Insights on MGMID in a pediatric patient w/juvenile idiopathic arthritis. Open Access.
link.springer.com/article/10.1...

Figure 1. From: Membranous-like glomerulopathy with masked IgG-k deposits in a pediatric patient with juvenile idiopathic arthritis. A Thickening of the glomerular basement membranes with abundant GBM “spikes” and “vacuoles” (Jones silver stain, × 400). B By routine immunofluorescence on fresh/frozen tissue, the glomeruli are negative for IgG and kappa and lambda light chains (× 400). C Following protease digestion of the formalin-fixed, paraffin-embedded tissue, direct immunofluorescence shows positive granular capillary wall staining for IgG and kappa light chain, and negative staining for lambda light chain (× 400). D Electron microscopy reveals numerous subepithelial immune-type electron-dense deposits with frequent GBM “spike” formation (× 4000)

IPNA Pediatric Nephrology @ped-neph.bsky.social · 21d

Complement inhibitor therapies, notably eculizumab, have been established as complement dysregulation disease treatment for more than a decade. Read this Editorial Commentary on a new era of complement inhibition: are we ready for the infectious risks?
link.springer.com/article/10.1...

Suggested meningococcal infection prevention strategies

IPNA Pediatric Nephrology @ped-neph.bsky.social · 22d

Takayasu arteritis (TAK) is a granulomatous large-vessel vasculitis typically affecting young adult females. Pediatric cases are rare. Read this Management Dilemma about kidney transplantation following abdominal aorto-aortic bypass in infantile TAK.
link.springer.com/article/10.1...

Navigating complex clinical decisions: kidney transplantation following abdominal aorto-aortic bypass in infantile Takayasu arteritis

IPNA Pediatric Nephrology @ped-neph.bsky.social · 22d

Pediatric hypertension is a concern, w/prolonged exposure to high BP potentially causing electrical instability & increasing arrhythmia risk. Read this Original Article on cardiac electrophysiological balance index.
link.springer.com/article/10.1...

A novel marker of electrical instability in children with hypertension: cardiac electrophysiological balance index

IPNA Pediatric Nephrology @ped-neph.bsky.social · 23d

The link between obesity, urine metabolic disturbances, & kidney stones in children & adolescents remains controversial. Read this Systematic Review /Meta-analysis of the association between BMI, urine metabolic disturbance, & pediatric nephrolithiasis.
link.springer.com/article/10.1...

Association between body mass index, urine metabolic disturbances, and nephrolithiasis in pediatric patients