Peter Gerlach
@peter-gerlach.bsky.social
PhD student in the Ioannidis Lab at Stanford University. Generally interested in population genetics.
Reposted by Peter Gerlach
How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS.
In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time!
doi.org/10.64898/202...
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In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time!
doi.org/10.64898/202...
1/n
High false sign rates in transcriptome-wide association studies
Transcriptome-wide association studies (TWAS) are widely used to identify genes involved in complex traits and to infer the direction of gene effects on traits. However, despite their popularity, it r...
doi.org
January 6, 2026 at 2:30 AM
How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS.
In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time!
doi.org/10.64898/202...
1/n
In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time!
doi.org/10.64898/202...
1/n
Reposted by Peter Gerlach
It was a pleasure to work with co-first-author @peter-gerlach.bsky.social, who led the proteomics analysis, along with our mentors @jeffspence.github.io and @jkpritch.bsky.social!
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January 6, 2026 at 2:30 AM
It was a pleasure to work with co-first-author @peter-gerlach.bsky.social, who led the proteomics analysis, along with our mentors @jeffspence.github.io and @jkpritch.bsky.social!
18/n
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