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Petri Kursula @petrikursula.bsky.social · Feb 4

Oh, I feel the pressure building up... 🧪

LINXS @linxsinstitute.bsky.social · Feb 4

Come meet our ChemLife guest researcher @petrikursula.bsky.social next month when he gives his seminar on The self-assembling proteolipid structure of myelin!

Details: www.linxs.se/events/2025-...

LINXS Guest Seminar: The self-assembling proteolipid structure of myelin with Petri Kursula - ChemLife — LINXS

Welcome to a seminar with LINXS guest researcher Petri Kursula!

www.linxs.se

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Reposted by Petri Kursula

Nina Kozlova @nina-kozlova.bsky.social · Jan 26

First post over here!
And it’s a link to our NDRG1 preprint!

bioRxivpreprint @biorxivpreprint.bsky.social · Jan 26

A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance https://www.biorxiv.org/content/10.1101/2025.01.22.634323v1

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Petri Kursula @petrikursula.bsky.social · Jan 21

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #9

Petri Kursula @petrikursula.bsky.social · Jan 12

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #8

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Reposted by Petri Kursula

1000WomeninSTEM @1000womeninstem.bsky.social · Jan 10

6️⃣6️⃣ Dorothy June Sutor (1929-1990) 🇳🇿 #womeninSTEM New Zealand crystallographer. She was the first to establish the existence of C - H ⋯ O hydrogen bonds in crystals in 1962. Her work was wrongly criticised by Jerry Donohue.

www.chemistryworld.com/features/the...

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Petri Kursula @petrikursula.bsky.social · Jan 11

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #7

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Reposted by Petri Kursula

Anonymous @youranoncentral.bsky.social · Jan 10

Over 60 German and Austrian universities, the German Federal Court of Justice and multiple top German football clubs have announced that they will be withdrawing from Twitter (X), due to US oligarch Elon Musk's "discussion" (collaboration) with Germany's neo-Nazi party (AfD) Alice Weidl.

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Petri Kursula @petrikursula.bsky.social · Jan 10

Yes this is exactly my strategy.

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Petri Kursula @petrikursula.bsky.social · Jan 10

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #6

6

Petri Kursula @petrikursula.bsky.social · Jan 8

Oh yes this 3rd edition from 1988 still lives on...

Petri Kursula @petrikursula.bsky.social · Jan 8

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #5

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Reposted by Petri Kursula

Mikko Tuomi @mustapipa.bsky.social · Dec 30

Näin tiede asetetaan poliittiseen kontrolliin.

"Akatemian tehtävien hoitaminen ei saa olla ristiriidassa Suomen kansallisen turvallisuuden, Suomen kansainvälisten velvoitteiden tai Suomen ulko- ja turvallisuuspolitiikan kanssa."
suomenkuvalehti.fi/mielipide/ku...

Kukaan ei huomannut uutista: hallitus vaatii huomioimaan ”turvallisuuteen liittyvät näkökohdat” tutkimuksen rahoituksessa

Luulisi, että esitys herättäisi uutisnälkäisessä toimittajassa kysymyksiä. Aletaanko Suomen Akatemiassa valvoa arvopohjaisen realismin noudattamista? kirjoittaa Anu Koivunen.

suomenkuvalehti.fi

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Petri Kursula @petrikursula.bsky.social · Dec 30

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #4

3

Petri Kursula @petrikursula.bsky.social · Dec 29

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky

#BookChallenge

#Books

Day #3

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Petri Kursula @petrikursula.bsky.social · Dec 28

Had a little holiday break but here we go again...
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #2

5

Petri Kursula @petrikursula.bsky.social · Dec 19

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order.
No explanations, no reviews, just covers.

#BookSky
#BookChallenge
#Books

Day #1

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Petri Kursula @petrikursula.bsky.social · Dec 17

#finland still has a lot to learn #racism www.theguardian.com/world/2024/d...

Black woman targeted by racist abuse in Finland over festival role

Finnish PM apologises to Daniela Owusu after she received hate messages after becoming first Black woman to represent Saint Lucia

www.theguardian.com

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Petri Kursula @petrikursula.bsky.social · Dec 13

One more preprint out - Santa can come now!
www.biorxiv.org/content/10.1... 🧪

Paratope mapping of tilvestamab, an anti-AXL function blocking antibody, using high-throughput bacterial expression of secreted scFv-ompY fusion proteins

Targeting AXL with a highly selective antibody presents a promising approach for inhibiting AXL and potentially improving cancer treatment. An essential step in antibody optimisation is the mapping of...

www.biorxiv.org

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Petri Kursula @petrikursula.bsky.social · Dec 10

The nanobodies were additionally expressed as intrabodies in both cultured oligodendrocytes and COS-7 cells. The nanobodies are freely available tools for structural biology as well as functional studies and molecular imaging.

Petri Kursula @petrikursula.bsky.social · Dec 10

Fluorescently labelled nanobodies were validated for staining of both teased nerve fibres and whole brain sections, as well as STED microscopy of nodes of Ranvier.

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Petri Kursula @petrikursula.bsky.social · Dec 10

We developed and characterised a set of high-affinity nanobody binders against the myelin enzyme CNPase. A thorough biophysical characterisation was accompanied by high-resolution X-ray crystallography to identify the precise epitopes for each nanobody.

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Petri Kursula @petrikursula.bsky.social · Dec 10

Hats off to funding sources and research infrastructures @unioulu.bsky.social @dfgpublic.bsky.social (again, cannot find most of you here but maybe soon).

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Petri Kursula @petrikursula.bsky.social · Dec 10

Great collaborative effort with good friends including @opazo.bsky.social @myelincentric.bsky.social @sigurbjornm.bsky.social and many others (sorry if I did not find the rest you on this platform yet).

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Petri Kursula @petrikursula.bsky.social · Dec 10

...and there we have it - the first paper for 2025 😀

onlinelibrary.wiley.com/doi/10.1111/...

Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies

The enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is abundant in non-compact myelin. While its in vitro catalytic activity is well understood, the in vivo function of CNPase remains un...

onlinelibrary.wiley.com

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Petri Kursula @petrikursula.bsky.social · Dec 10

Hehe, this is great! 7 years in the making, but only the starting point for the future - followup data are already being collected. 🧪

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