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Pierre Apostolides

@pfapostolides.bsky.social

83 followers 82 following 64 posts

Cellular physiologist LARPing as a systems neuroscientist. Enthusiastic about new age music, fine scale model building (mostly styrene, sometimes computational), and non-linear processes in biological networks. www.apostolideslab.org

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Pierre Apostolides @pfapostolides.bsky.social · 20h

Yessss. Very happy to read this.

Cf pubmed.ncbi.nlm.nih.gov/19198604/

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 1d

iGABASnFR Imaging Reveals Diffusion-Driven GABA Clearance in the Cerebral Cortex https://www.biorxiv.org/content/10.1101/2025.10.07.680664v1

Pierre Apostolides @pfapostolides.bsky.social · 4d

Emilio Estevez’ second best, next to Repo Man

Pierre Apostolides @pfapostolides.bsky.social · 14d

Cool paper. love how far the work has come from initial characterization of cellular consequences of SCN2A mutations to roadmap for therapeutic strategies.

Kevin Bender @neurobender.bsky.social · 21d

SCN2A loss is strongly linked to neurodevelopmental delays and, at times, seizure. In an amazing collaboration with @nadavahituv.bsky.social, led by Serena Tamura, Andrew Nelson, and Perry Spratt, we leveraged CRISPR activator approaches to rescue this loss.

rdcu.be/eGU0W

CRISPR activation for SCN2A-related neurodevelopmental disorders

Nature - Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in...

rdcu.be

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Pierre Apostolides @pfapostolides.bsky.social · 16d

Thank you to NIMH for supporting our work. Excited to keep thinking about reinforcement learning in the auditory midbrain.

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Reposted by Pierre Apostolides

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 21d

Coincidence detection supported by electrical synapses is shaped by the D-type K+ current https://www.biorxiv.org/content/10.1101/2025.09.17.676857v1

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Pierre Apostolides @pfapostolides.bsky.social · 23d

First day in a new brain region. We’re gonna have so much fun here.

Reposted by Pierre Apostolides

Ross Williamson @rswilliamson.bsky.social · Sep 6

Really excited to share the latest work from my lab, where we identify how distinct cortical projections differentially encode sensory category and choice.

A cortical output channel for perceptual categorization

Perceptual categorization allows the brain to transform diverse sensory inputs into discrete representations that support flexible behavior. Auditory cortex (ACtx) has been implicated in this process,...

www.biorxiv.org

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Pierre Apostolides @pfapostolides.bsky.social · Sep 4

slice cultures are actually pretty cool because culturing massively increases local connectivity

Pierre Apostolides @pfapostolides.bsky.social · Sep 4

This is cool. Peptide modulation of circuit excitability. Makes me think that peptide release might be a reason why so many of these interneuron types do the retro-axonal barrage firing thing

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Sep 4

Somatostatin released by single O-LM interneurons slowly inhibits intrinsic neuronal excitability in a paracrine and autocrine manner https://www.biorxiv.org/content/10.1101/2025.08.31.673310v1

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Pierre Apostolides @pfapostolides.bsky.social · Sep 3

What a horrible night to have a curse (of dimensionality)

Pierre Apostolides @pfapostolides.bsky.social · Sep 1

Predictive processing at its finest.

Pierre Apostolides @pfapostolides.bsky.social · Aug 26

Just asked GPT5 what it thinks about whole-cell voltage clamp

Pierre Apostolides @pfapostolides.bsky.social · Aug 25

GPT just caught a really nasty error in my code that I had missed. How can anyone say this isn’t useful

Reposted by Pierre Apostolides

The Society Of Rockets @societyofrockets.bandcamp.com · Aug 8

Happy 808 Day B-Girls and B-Boys! Is there honestly a more iconic piece of music tech? Also, bonus points for any nerds that can properly name the electro-baller in the photo.

#808day #tr808 #drummachine #electro #hiphop #rap #musictech #analog #musiccommunity #techno #acidhouse

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Pierre Apostolides @pfapostolides.bsky.social · Aug 1

Deleted post because I subsequently saw that a Figs pun has already been made. Not novel, incremental, will revise.

Pierre Apostolides @pfapostolides.bsky.social · Jul 20

So this?

media.tenor.com/n0VLot3ppZkA...

media.tenor.com

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Reposted by Pierre Apostolides

Drug Monkey @drugmonkey.bsky.social · Jul 19

You keep putting up proposals until you happen to get a favorable set of three reviewers who are also iconoclast enough to argue for your non-mainstream idea.

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Reposted by Pierre Apostolides

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jul 12

Synaptic properties of layer 6 auditory corticothalamic inputs in normal hearing and noise-induced hearing loss https://www.biorxiv.org/content/10.1101/2025.07.08.663770v1

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Pierre Apostolides @pfapostolides.bsky.social · Jul 11

What I’m hearing you say is that the theory needs to make explicit predictions about the biophysics and squishy biology that underlies the algorithm. There’s some great examples of this in Eve Marder’s work, and also the work Angus Silver did in granule cell layer these past 15 years.

Pierre Apostolides @pfapostolides.bsky.social · Jul 8

Gonna start patching cultured neurons again

Pierre Apostolides @pfapostolides.bsky.social · Jul 2

I love Ulver because it’s Depeche Mode for metal dudes who don’t want to admit they like Depeche Mode.

Pierre Apostolides @pfapostolides.bsky.social · Jul 2

A new Perturbator single with…Ulver? 2025 keeps getting better.

Pierre Apostolides @pfapostolides.bsky.social · Jul 1

Yeah that would make sense actually. Cool!!

Pierre Apostolides @pfapostolides.bsky.social · Jul 1

Desensitization of a resting ATP-gated conductance?

Pierre Apostolides @pfapostolides.bsky.social · Jul 1

Awesome! What’s the outward component due to?

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