Emily Diseroad, PharmD, BCPPS
@pharmdemily.bsky.social
Pediatric Critical Care PharmD @ CCHMC. Fast Pitch Softball Player. Maryland Native. Reader. John’s Personal Chef.
views are my own and do not reflect the views of my employer
#pharmsky #pedsICU #medsky #PCCM
views are my own and do not reflect the views of my employer
#pharmsky #pedsICU #medsky #PCCM
I'm so disappointed I didn't know this was a hazard of gel nail polish use. More people need to know the risks!
January 26, 2025 at 6:36 PM
I'm so disappointed I didn't know this was a hazard of gel nail polish use. More people need to know the risks!
For a more technical read:
2‐Hydroxyethyl methacrylate (HEMA): A clinical review of contact allergy and allergic contact dermatitis—Part 1. Introduction, epidemiology, case series and case reports
2-Hydroxyethyl methacrylate (HEMA) has been increasingly recognised as a contact allergen and was added to the European baseline series in 2019. In this article (2 parts), the results of an extensive...
onlinelibrary.wiley.com
January 26, 2025 at 6:36 PM
For a more technical read:
It started with weeks of skin peeling that I thought was just dry skin in this cold weather... but I finally put it together when I woke up with swollen, itchy, red, and tingly fingers. I had my gel removed promptly but no resolution of symptoms yet.
The Nail Hub has a short article on this:
The Nail Hub has a short article on this:
Understanding HEMA and Its Role in Nail Allergies
a common ingredient in many nail products, especially gel and acrylic nails. While HEMA is essential for the durability and adhesion of these products, it also poses a risk of causing allergic reactio...
www.thenailhub.com
January 26, 2025 at 6:36 PM
It started with weeks of skin peeling that I thought was just dry skin in this cold weather... but I finally put it together when I woke up with swollen, itchy, red, and tingly fingers. I had my gel removed promptly but no resolution of symptoms yet.
The Nail Hub has a short article on this:
The Nail Hub has a short article on this:
My take: interpret these results with ⚠️caution⚠️! Maximal receptor activity does not necessarily correlate with appropriate clinical response/desired effect. I would think of these more as max dose recommendations vs starting doses. I won't be applying these recommendations in the #PICU for IWS.
January 26, 2025 at 6:24 PM
My take: interpret these results with ⚠️caution⚠️! Maximal receptor activity does not necessarily correlate with appropriate clinical response/desired effect. I would think of these more as max dose recommendations vs starting doses. I won't be applying these recommendations in the #PICU for IWS.
They specifically compared these doses to those standardly used for NAS in neonates and ADHD and Tourette’s syndrome in children - stating that usual prescribed doses do not result in maximal α-2 agonist activity.
January 26, 2025 at 6:24 PM
They specifically compared these doses to those standardly used for NAS in neonates and ADHD and Tourette’s syndrome in children - stating that usual prescribed doses do not result in maximal α-2 agonist activity.
The authors conclude: "Based on pediatric PBPK model simulations, the doses 30 mCg/kg for neonates and 0.4 mg/day for children are recommended to reach a target concentration that are predicted to result in maximal α-2 agonist activity."
January 26, 2025 at 6:24 PM
The authors conclude: "Based on pediatric PBPK model simulations, the doses 30 mCg/kg for neonates and 0.4 mg/day for children are recommended to reach a target concentration that are predicted to result in maximal α-2 agonist activity."
Dr. Parker nicely summarizes current evidence in iron deficiency in critically ill children!
January 6, 2025 at 2:34 PM
Dr. Parker nicely summarizes current evidence in iron deficiency in critically ill children!
December 20, 2024 at 12:55 PM
Major pro of epoprostenol for CRRT anticoagulation: no therapeutic monitoring
Major con: underperformance of filter life according to Deep et al (when compared with other studies reporting on citrate and heparin)
Major con: underperformance of filter life according to Deep et al (when compared with other studies reporting on citrate and heparin)
December 20, 2024 at 12:52 PM
Major pro of epoprostenol for CRRT anticoagulation: no therapeutic monitoring
Major con: underperformance of filter life according to Deep et al (when compared with other studies reporting on citrate and heparin)
Major con: underperformance of filter life according to Deep et al (when compared with other studies reporting on citrate and heparin)
Providing my #PICU perspective...
Valproic acid is on the #KIDSlist (avoid in <2 yrs, caution in <6 yrs). Would avoid in pts on carbapenems or may need a carbapenem, liver failure or on other hepatotoxic meds, and pancreatitis.
Could use as a last line therapy in the remaining narrow population
Valproic acid is on the #KIDSlist (avoid in <2 yrs, caution in <6 yrs). Would avoid in pts on carbapenems or may need a carbapenem, liver failure or on other hepatotoxic meds, and pancreatitis.
Could use as a last line therapy in the remaining narrow population
December 15, 2024 at 1:40 PM
Solodiuk, et al developed the WAT-A2A tool to monitor for dexmedetomidine and clonidine withdrawal in acutely ill children. Different from WAT-1, it includes HR and DBP. Inter-rater reliability was high.
December 15, 2024 at 1:23 PM
Solodiuk, et al developed the WAT-A2A tool to monitor for dexmedetomidine and clonidine withdrawal in acutely ill children. Different from WAT-1, it includes HR and DBP. Inter-rater reliability was high.
I have long been a critic of using the WAT-1 tool for assessment of alpha-2 agonist withdrawal, despite the PANDEM recommendations to use symptoms + benzo/opioid withdrawal screening tool to monitor for IWS. Anecdotally, I believe this strategy results in many false positives.
December 15, 2024 at 1:18 PM
I have long been a critic of using the WAT-1 tool for assessment of alpha-2 agonist withdrawal, despite the PANDEM recommendations to use symptoms + benzo/opioid withdrawal screening tool to monitor for IWS. Anecdotally, I believe this strategy results in many false positives.