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Phase Genomics @phasegenomics.bsky.social · 21h

Skip the computational guesswork. Hi-C / proximity ligation reveal complete chromosomal architecture based on actual intracellular contacts.

From plant genomes to metagenomes, Phase Genomics delivers chromosome-scale assemblies traditional methods can’t: phasegenomics.com/resources-an...

Phase Genomics @phasegenomics.bsky.social · 8d

In this great new paper, the authors use metagenomic Hi-C to show that #phage with broad host range are fairly common, contrary to the prevailing view on their biology. Cutting edge methods like Hi-C are shedding light on our blind spots in the microbial world.

Phages with a broad host range are common across ecosystems - Nature Microbiology

Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.

www.nature.com

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Phase Genomics @phasegenomics.bsky.social · 14d

ProxiMeta™ turns your benchtop box into a Hi-C metagenomics powerhouse. Order before Sept. 30 to lock in 20% savings on the 8-sample ProxiMeta Classic Hi-C Kit, or 50% on the 2-sample ProxiMeta Starter Hi-C Kit.

🔗https://phasegenomics.com/contact-us/

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Phase Genomics @phasegenomics.bsky.social · 21d

Don’t let your lab’s grant dollars go to waste. Order before September 30 to save 20% on ProxiMeta™ Classic Hi-C Kit, or 50% on the ProxiMeta Starter Hi-C Kit.

✔️ Hands-off workflow ✔️ Flexible timelines ✔️ PGShield™ to keep samples shelf-stable

🔗https://phasegenomics.com/contact-us/

Phase Genomics @phasegenomics.bsky.social · 26d

Join us at the Microbiome Innovation One Health Conference in Oxford on Sept 15! @ivanliachko.bsky.social will present how ProxiMeta™ maps microbes, viruses, plasmids & resistance genes, bringing clarity to complexity across human, animal and environmental health.

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Phase Genomics @phasegenomics.bsky.social · Sep 4

🧬 Important Slug News!
Researchers assembled a chromosome-scale #genome for Deroceras laeve using Proximo Hi-C and @pacbio.bsky.social - making it a useful model for study of #genomics, #evolution, and slimyness... Congrats to Alfredo Varela-Echavarría & team!

🔗 academic.oup.com/g3journal/ad...

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Phase Genomics @phasegenomics.bsky.social · Aug 21

A fungus among us: Proximo Hi‑C + @pacbio.bsky.social HiFi produced telomere‑to‑telomere genomes for VCG‑01111/01112, uncovering 4 accessory chromosomes, >3.6 My divergence, SIX6 and novel effectors—pinpointing drivers of high virulence. www.mdpi.com/2309-608X/11...

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Phase Genomics @phasegenomics.bsky.social · Aug 19

Stanford researchers just achieved another 1st: Using ProxiMeta™, helped isolate p-crAssphage, a common gut virus and shape shifter that can switch between producing viruses and quietly living in bacteria like a plasmid. Read more in @cp-cellhostmicrobe.bsky.social: www.cell.com/cell-host-mi...

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Reposted by Phase Genomics

Ivan Liachko @ivanliachko.bsky.social · Aug 12

New study uses long-read + @phasegenomics.bsky.social Hi-C to assemble chromosome-scale #genome of Trichomonas vaginalis and bird-infecting relatives, revealing key genes tied to bird-to-human spillover. Congrats to Jane Carlton, ‪@mikeschatz.bsky.social‬ and team!

Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in spillover from birds to humans - Nature Communications

The sexually transmitted human parasite Trichomonas vaginalis belongs to a clade of host-switching trichomonads that parasitize mammals, birds, livestock, and pets. Here the authors describe a chromos...

nature.com

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Phase Genomics @phasegenomics.bsky.social · Aug 6

Structural variants often go undetected by traditional cytogenetics. A new review in Genes shows how Genomic Proximity Mapping™ (GPM) detects complex SVs right from FFPE. Read more Dr. Patrick Gonzales at the University of Kansas Medical Center: www.mdpi.com/2073-4425/16...

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Phase Genomics @phasegenomics.bsky.social · Aug 5

Scenes from #CGC2025: Min Fang, MD, PhD at Fred Hutch shared how Genomic Proximity Mapping™ (GPM) powers her next-gen cytogenomic analysis in AML. If you’re at #CGC2025 this year, stop by booth 23 to speak with the Phase Genomics team about how #GPM can accelerate your research!

Phase Genomics @phasegenomics.bsky.social · Aug 4

When sample quality is low, insight usually is too. Not with Genomic Proximity Mapping™ (GPM).

Phase Genomics’ GPM works on #FFPE and mosaic samples. It’s just one assay, no metaphase prep, and no tradeoff in resolution. A new preprint shows how: www.medrxiv.org/content/10.1...

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Phase Genomics @phasegenomics.bsky.social · Aug 1

Comprehensive cytogenetics from any sample type—including #FFPE—in just one assay:

CytoTerra® delivers genome-wide SV detection with no culture, no HMW DNA, and results in as little as 5 days. Stop by booth 23 & check out our presentations to see it in action at #CGC2025.

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Phase Genomics @phasegenomics.bsky.social · Jul 28

A major advance in the field of human #genetics and #cancer #genomics! As always, we are proud to have been able to contribute our small part to this huge undertaking.

🧬 130 haplotypes, many T2T
🧬 Closed 92% of assembly gaps
🧬 1,852 complex SVs
🧬 1,246 centromeres

www.nature.com/articles/s41...

Complex genetic variation in nearly complete human genomes - Nature

Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

www.nature.com

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Phase Genomics @phasegenomics.bsky.social · Jul 25

🌸 Chromosome-scale genome of Petunia hybrida assembled with Proximo Hi-C, PacBio HiFi, Illumina & Bionano. 7 pseudochromosomes, 99.8% BUSCO with Hi-C being key for resolving repeats. A powerful resource for Solanaceae genetics & breeding. #genome #HiC

📄 hubs.la/Q03ypPmb0

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Phase Genomics @phasegenomics.bsky.social · Jul 23

Introducing PGShield™ - our new room-temperature sample solution for Hi-C. No more dry ice shipments. Improved data quality and library yields. Store your samples for months without sacrificing data quality. Get a FREE 10mL bottle today! #genomics #HiC
🔗https://hubs.la/Q03yhGWf0

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Phase Genomics @phasegenomics.bsky.social · Jul 22

🌱🧬Researchers released haplotype-resolved, chromosome-level genomes of Eupatorium splendens - a plant known for medicinal properties and ability to thrive in contaminated soils. A powerful resource for studying stress adaptation & secondary metabolism. www.nature.com/articles/s41...

Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) - Scientific Data

Scientific Data - Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.)

www.nature.com

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Phase Genomics @phasegenomics.bsky.social · Jul 15

🍓 Meet ‘Yuexin’ - a next-gen #strawberry with smoother texture, better shelf life, and sweeter aroma. Scientists have released its fully phased #genome, revealing the genetic secrets behind these tasty traits. Proximo #HiC +
@pacbio.bsky.social for the win! 🧬

🔗 hubs.la/Q03tZvZD0

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Phase Genomics @phasegenomics.bsky.social · Jul 10

Meet the new ProxiMeta™ Starter Bundle, your all-in-one solution perfect for pilot studies and early-career researchers. It includes everything you need—from reagents to one-click data access—with success guaranteed for up to two samples. Learn more: bit.ly/4nEZMNF

Phase Genomics @phasegenomics.bsky.social · Jul 9

“It’s not a brute force technology. It’s a clever technology.”
— Jon Chee, CEO @ Excedr

In the finale of The Biotech Startups Podcast, Jon and @ivanliachko.bsky.social unpack how smart science powers Phase Genomics' impact in cancer research, metagenomics & more👇
youtu.be/fqL6ZvS2sNQ?...

Growth Without Venture Capital: The Bootstrapped Biotech Playbook | Ivan Liachko (Part 4/4)

YouTube video by The Biotech Startups Podcast | Excedr

youtu.be

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Phase Genomics @phasegenomics.bsky.social · Jul 8

New💩🚰👨‍🔬 study in #EnvMicrobiology uses shotgun & Hi-C metagenomics to reveal rapid shifts in antibiotic resistance genes and their microbial hosts, highlighting the dynamic nature of resistomes. #AMR #Metagenomics

🔗https://hubs.la/Q03tZ1Jf0

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Phase Genomics @phasegenomics.bsky.social · Jul 3

TBT: 🧬 Throwing it back to a cool study from Aug 2021! Using proximity ligation, this paper explores the two-compartment genome of R. irregularis, a model arbuscular mycorrhizal symbiont, using Proximo #HiC and @nanoporetech.com sequencing. @Blunt_Microbe

🔗 Full study: hubs.la/Q03tZ6Ch0

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Phase Genomics @phasegenomics.bsky.social · Jul 2

“If we don’t commercialize this, it’s going to be a crime against science.” - @ivanliachko.bsky.social, Founder and CEO

Hear how a postdoc aha moment became a platform accelerating #microbiome research, tackling #AMR & more on the Biotech Startups Podcast: www.youtube.com/watch?v=U2UG...

How 3D Genome Mapping is Changing Everything We Know About DNA | Ivan Liachko (Part 3/4)

YouTube video by The Biotech Startups Podcast | Excedr

www.youtube.com

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Phase Genomics @phasegenomics.bsky.social · Jul 1

Unleashing the wild side of lupins! 🌕🐺🍃
Researchers built #genomes of rough-seeded lupins - L. cosentinii & L. digitatus - revealing unique #gene expansions tied to stress resilience and seed traits. A howling good resource for legume breeding! #HiC
🔗 hubs.la/Q03v1F2c0

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Phase Genomics @phasegenomics.bsky.social · Jun 27

Can’t see the full picture with karyotyping or microarrays?

New research in
@Genes_MDPI
shows how Genomic Proximity Mapping (GPM) detects structural variants other tools miss - translocations, insertions & CN-LOH - even from FFPE!
hubs.la/Q03v2s2N0

#Cancer #Cytogenetics

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