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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT
@picowerinstitute.bsky.social
130 followers 79 following 45 posts
A community of more than 250 MIT researchers dedicated to understanding the fundamental mechanisms of how the brain works and applying that insight to disease.
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 1d
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 1d
Our labs' studies have revealed a number of ways moods emerge in the brain and therefore are providing potential paths to address depression, PTSD, anxiety and bipolar disorder. Learn more in our Fall newsletter cover story. picower.mit.edu/news/many-me...
#neuroscience #depression #anxiety #bipolar
Many Mechanisms of Mood
Picower Institute studies reveal a number of ways moods emerge in the brain and therefore many potential paths to address depression, PTSD, anxiety and bipolar disorder.
picower.mit.edu
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 2d
Visually observing neural activity in freely moving animals requires identifying and tracking moving cells. In @elife.bsky.social the Flavell lab describes deep neural networks to enable this in a nematode worm (and applies some to jellyfish too!). elifesciences.org/reviewed-pre... #neuroscience
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 7d
Congratulations to Linlin Fan on earning a BBRF Young Investigator grant! 'Using all-optical methods, Fan’s lab will study whether and how serotonin modulates plasticity. bbrfoundation.org/content/brai... #neuroscience #memory
Brain & Behavior Research Foundation Awards 165 Young Investigator Grants to Advance Mental Health Research | Brain & Behavior Research Foundation
$11.4 million in two-year awards—selected from 895 applications—will fuel early-career breakthroughs in depression, schizophrenia, anxiety, PTSD, addiction, and more.
bbrfoundation.org
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 8d
Register now for "Circuits of Survival and Homeostasis" on 10/21! Seven talks will cover how brain-body circuits monitor, regulate, and repair fundamental physiological functions, offering insights into their mechanisms and potential therapeutic targets. docs.google.com/forms/d/e/1F... #neuroscience
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 9d
Hi! We expect to be able to post a selection of talks soon. Watch the story link.👀
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 9d
Before a packed house, speakers at MIT’s Aging Brain Initiative symposium 9/18 described how immune system factors during aging contribute to #Alzheimers, #Parkinsons and other conditions. The field is leveraging that knowledge to develop new therapies. picower.mit.edu/news/immune-...
Immune-informed brain aging research offers new treatment possibilities, speakers say
Before a packed house, speakers at MIT’s Aging Brain Initiative symposium described how immune system factors during aging contribute to Alzheimer’s, Parkinson’s and other conditions. The field is lev...
picower.mit.edu
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Reposted by The Picower Institute for Learning and Memory at MIT
earlkmiller.bsky.social
Earl K. Miller @earlkmiller.bsky.social · 16d
New paper!
Evidence for an active handoff between hemispheres during target tracking
www.jneurosci.org/content/earl...
#neuroscience
Evidence for an active handoff between hemispheres during target tracking
The brain has somewhat separate cognitive resources for the left and right sides of our visual field. Despite this lateralization, we have a smooth and unified perception of our environment. This rais...
www.jneurosci.org
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 16d
Full study: www.jneurosci.org/content/earl...
Evidence for an active handoff between hemispheres during target tracking
The brain has somewhat separate cognitive resources for the left and right sides of our visual field. Despite this lateralization, we have a smooth and unified perception of our environment. This rais...
www.jneurosci.org
1
picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 16d
As an object moves across your field of view, the brain seamlessly hands off visual processing from one hemisphere to the other like cell phone towers or relay racers do, a new study by @earlkmiller.bsky.social in @sfnjournals.bsky.social shows. picower.mit.edu/news/how-bra...
#neuroscience
How the brain splits up vision without you even noticing
As an object moves across your field of view, the brain seamlessly hands off visual processing from one hemisphere to the other like cell phone towers or relay racers do, a new MIT study shows.
picower.mit.edu
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 28d
Research study in @nature.com: www.nature.com/articles/s41...
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons - Nature
Loss-of-function variants of ABCA7, associated with Alzheimer’s disease, result in disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways in the human brain.
www.nature.com
picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 28d
A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to the development of #Alzheimers in some of the people who carry it. picower.mit.edu/news/study-e... @mitbcs.bsky.social #neuroscience
Study explains how a rare gene variant contributes to Alzheimer’s disease
Lipid metabolism and cell membrane function can be disrupted in the neurons of people who carry rare variants of ABCA7.
picower.mit.edu
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 29d
🫁↔️🧠 A review by Sara Prescott's lab lays out the latest airway-brain circuits research and makes the case that "ongoing research promises new insights into airway disease mechanisms and the neural basis of breathing-related behaviors." www.sciencedirect.com/science/arti... #biology #neuroscience
The airway-brain axis: Connecting breath, brain, and behavior
The neural control of breathing is both dynamic and essential, ensuring life-sustaining gas exchange while protecting the respiratory system from harm…
www.sciencedirect.com
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Sep 4
How do neurons sense (or get tricked by) the bacteria in the microbiome? A new preprint from the lab of Steve Flavell led by Cassi Estrem identifies chemical cues that trigger neurons in C. elegans models. www.biorxiv.org/content/10.1... #neuroscience #microbiome @mitbcs.bsky.social
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Sep 2
Excited (!) for our investigator Brady Weissbourd who will study how jellyfish larvae sense and use environmental cues to explore their world and decide where to settle, offering insights into marine population dynamics, invasive species control, and the neural basis of decisions in early life.
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Sep 2
Open access paper in @cp-cell.bsky.social by the labs of Manolis Kellis and Li-Huei Tsai: www.cell.com/cell/fulltex...
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience
A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...
www.cell.com
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Sep 2
A sweeping study by MIT researchers shows the importance of understanding #Alzheimers disease as a battle over how well brain cells regulate the expression of their genes. picower.mit.edu/news/alzheim... #neuroscience #epigenomics @mitbcs.bsky.social @csail.mit.edu
Alzheimer’s erodes brain cells’ control of gene expression, undermining function, cognition
Study of 3.5 million cells from more than 100 human brains finds that Alzheimer’s progression—but also resilience to disease—depends on preserving epigenomic stability.
picower.mit.edu
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Aug 27
Don't skip the textbook section!
thetransmitter.bsky.social
The Transmitter @thetransmitter.bsky.social · Aug 27
In The Transmitter's reading list, we highlight the most anticipated upcoming neuroscience books and other notable 2025 releases. Featuring titles by @okaysteve.bsky.social, @dr-brein.bsky.social, @nicolecrust.bsky.social,‬ Xiao-Jing Wang and many more.

By @franciscorr25.bsky.social
bit.ly/45MvK41
The Transmitter’s reading list: Six upcoming neuroscience books, plus notable titles in 2025
Dig into an exploration of the fundamental aspects of intelligence, a new textbook about theoretical neuroscience and a memoir about memory research, among other new releases.
bit.ly
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Reposted by The Picower Institute for Learning and Memory at MIT
thetransmitter.bsky.social
The Transmitter @thetransmitter.bsky.social · Aug 27
In The Transmitter's reading list, we highlight the most anticipated upcoming neuroscience books and other notable 2025 releases. Featuring titles by @okaysteve.bsky.social, @dr-brein.bsky.social, @nicolecrust.bsky.social,‬ Xiao-Jing Wang and many more.

By @franciscorr25.bsky.social
bit.ly/45MvK41
The Transmitter’s reading list: Six upcoming neuroscience books, plus notable titles in 2025
Dig into an exploration of the fundamental aspects of intelligence, a new textbook about theoretical neuroscience and a memoir about memory research, among other new releases.
bit.ly
2 15 43
picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Aug 27
🗓️If you are gonna be around Boston Sept. 18 and are interested in how the immune and nervous systems intersect in the context of brain aging, we've got an amazing day planned for you! Join us. Registration is open! picower.mit.edu/events/neuro... #neuroscience #alzheimers #aging #immunology
The Neuro-Immune Axis and the Aging Brain
picower.mit.edu
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Reposted by The Picower Institute for Learning and Memory at MIT
earlkmiller.bsky.social
Earl K. Miller @earlkmiller.bsky.social · Aug 20
Inside the search for a universal signature of unconsciousness
bigthink.com/neuropsych/u...
"Neuroscientists like Earl K. Miller argue that the brain’s coordinated waves do the real work"
#neuroscience @picowerinstitute.bsky.social @mitbcs.bsky.social
Inside the search for a universal signature of unconsciousness
A universal marker of unconsciousness could transform both medicine and our understanding of the mind.
bigthink.com
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Reposted by The Picower Institute for Learning and Memory at MIT
earlkmiller.bsky.social
Earl K. Miller @earlkmiller.bsky.social · Aug 19
@matthiasmichel.bsky.social and I are pleased as punch to present the Fall schedule for the new MIT Consciousness Club.
sites.google.com/view/mit-con...
#neuroscience
MIT Consciousness Club
The MIT Consciousness Club aims to foster interdisciplinary research on consciousness at MIT and in the broader Boston area by organizing a monthly event featuring an expert talk on consciousness foll...
sites.google.com
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picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Aug 7
Full study: www.nature.com/articles/s41...
Multi-photon, label-free photoacoustic and optical imaging of NADH in brain cells - Light: Science & Applications
Label-free, multiphoton photoacoustic microscope (LF-MP-PAM) with a near-infrared femtosecond laser to observe endogenous NAD(P)H of neurons in brain slices and cerebral organoids.
www.nature.com
picowerinstitute.bsky.social
The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · Aug 7
By combining several cutting-edge imaging technologies, a new microscope system could enable unprecedentedly deep and precise visualization of metabolic and neuronal activity, potentially even in humans picower.mit.edu/news/mit-ima... #neuroscience #microscopy @mitbcs.bsky.social
MIT imaging tech promises deepest looks yet into living brain tissue at single-cell resolution
By combining several cutting-edge imaging technologies, a new microscope system could enable unprecedentedly deep and precise visualization of metabolic and neuronal activity, potentially even in huma...
picower.mit.edu
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Reposted by The Picower Institute for Learning and Memory at MIT
earlkmiller.bsky.social
Earl K. Miller @earlkmiller.bsky.social · Aug 5
Senior professors only wear lab coats for warmth.
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