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pinkigahlot.bsky.social
Pinki Gahlot
@pinkigahlot.bsky.social
26 followers 31 following 3 posts
Doctoral researcher in the Meyer lab at University of Duisburg-Essen Cellular stress | Lysosomal damage | Neurodegeneration
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pinkigahlot.bsky.social
Pinki Gahlot @pinkigahlot.bsky.social · Aug 11
Thank you! :)
Reposted by Pinki Gahlot
hemmo-lab.bsky.social
Hemmo Meyer Lab @hemmo-lab.bsky.social · Aug 10
Excellent thesis defense by Pinki Gahlot concluding brillant work on a sensor module, SPG20-ITCH that detects lipid packing defects in the limiting membrane of permeabilized #lysosomes and initiates #lysophagy.
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Reposted by Pinki Gahlot
natrevmcb.nature.com
Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · Aug 4
New Online! Lysosomal membrane homeostasis and its importance in physiology and disease
Lysosomal membrane homeostasis and its importance in physiology and disease
Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.
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Reposted by Pinki Gahlot
embojournal.org
The EMBO Journal @embojournal.org · Jul 30
ATXN3-p97 facilitates #lysosomal restoration after damage by deubiquitinating LAMP2 and targeting it for degradation via microautophagy
Hemmo Meyer and coworkers @hemmo-lab.bsky.social
www.embopress.org/doi/full/10....
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pinkigahlot.bsky.social
Pinki Gahlot @pinkigahlot.bsky.social · Aug 4
Timing could be one of the factors. Additionally, I would say that the extent of damage would be a determinant as well in that case.
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pinkigahlot.bsky.social
Pinki Gahlot @pinkigahlot.bsky.social · Aug 1
Thrilled to share our work on the role of Ataxin-3 in lysosome regeneration published in @embojournal.org . Here we show that Atxn3 targets K48-K63 branched ubiquitin chains on damaged lysosomes and mediates restoration of lysosomal function via microautophagy.

www.embopress.org/doi/full/10....
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