Tonu Pius
@piustonu.bsky.social
🦠 #MRSA Immunotherapeutics 🥼 Missiakas Lab | Vaccine 💉 ImmunArtes | Visualizing discovery 🎥 CINEscience | 🇮🇳🇺🇸
Reposted by Tonu Pius
Thrilled to share my work from the @jkagan1.bsky.social lab!
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus
Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...
www.biorxiv.org
September 26, 2025 at 11:31 AM
Thrilled to share my work from the @jkagan1.bsky.social lab!
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
Reposted by Tonu Pius
I’m excited to share our latest work! We challenge the widely thought notion that cohousing and cross-fostering can normalize the microbiomes of genetically distinct mice: www.cell.com/cell-reports... 🐁🦠🧬
Cohousing or cross-fostering followed by cohousing does not normalize the microbiomes of genetically distinct adult mice
Lietuvninkas et al. use state-of-the-art gnotobiotic approaches to investigate whether
cohousing or cross-fostering overpower the role of genetics in shaping the fecal bacterial
commensal population. ...
www.cell.com
October 9, 2025 at 8:55 AM
I’m excited to share our latest work! We challenge the widely thought notion that cohousing and cross-fostering can normalize the microbiomes of genetically distinct mice: www.cell.com/cell-reports... 🐁🦠🧬
Reposted by Tonu Pius
A major challenge in RNA delivery is overcoming poor loading efficiency into nanoparticles. F. Machinandiarena solves this by using "SSHELs", our particles inspired by bacterial spores, to deliver RNA specifically to HER2+ ovarian cancer cells.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me
December 20, 2025 at 4:11 PM
A major challenge in RNA delivery is overcoming poor loading efficiency into nanoparticles. F. Machinandiarena solves this by using "SSHELs", our particles inspired by bacterial spores, to deliver RNA specifically to HER2+ ovarian cancer cells.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Reposted by Tonu Pius
Lantibiotic-producing bacteria impact microbiome resilience & resistance
Gut colonization w/ lantibiotic-producing Blautia pseudococcoides SCSK prevents recovery of antibiotic-induced dysbiosis & increases susceptibility to K. pneumoniae & C. difficile
www.cell.com/cell-host-mi...
Gut colonization w/ lantibiotic-producing Blautia pseudococcoides SCSK prevents recovery of antibiotic-induced dysbiosis & increases susceptibility to K. pneumoniae & C. difficile
www.cell.com/cell-host-mi...
Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance
Lantibiotic-producing gut commensals are prevalent in human gut microbiomes. Cole
et al. demonstrate that gut colonization with lantibiotic-producing Blautia pseudococcoides
SCSK (BpSCSK) prevents rec...
www.cell.com
December 3, 2025 at 4:11 PM
Lantibiotic-producing bacteria impact microbiome resilience & resistance
Gut colonization w/ lantibiotic-producing Blautia pseudococcoides SCSK prevents recovery of antibiotic-induced dysbiosis & increases susceptibility to K. pneumoniae & C. difficile
www.cell.com/cell-host-mi...
Gut colonization w/ lantibiotic-producing Blautia pseudococcoides SCSK prevents recovery of antibiotic-induced dysbiosis & increases susceptibility to K. pneumoniae & C. difficile
www.cell.com/cell-host-mi...