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Plenty of Room - Newsletter @plenty-of-room.bsky.social · 23d

Yeah it's an interesting comparison! I like DNA as a scaffold, but proteins have amazing functionality!

Plenty of Room - Newsletter @plenty-of-room.bsky.social · 24d

Can we play Lego using proteins? Oh yeah! With some help from machine learning 🧪🧬🖥️

Read how here! plentyofroom.beehiiv.com/p/ai-designe...

AI-Designed Protein Nanoassembly: Molecular Lego's Next Frontier!

AI-powered protein design creates modular nanostructures, transforming molecular engineering by unlocking protein building blocks that assemble like dynamic Lego components.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Sep 4

Can you use DNA traps to fight tumors?

This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬

Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr

DNA Trash Cans: Outsmarting Tumor Signals with Origami Tech!

DNA origami creates innovative "tumor traps" that capture cancer-signaling molecules, offering a groundbreaking approach to targeting and neutralizing uncontrolled cellular growth.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Sep 2

What do emus (yeah, the bird!) and protein dynamics have in common? 🧪

More than you would expect! Don't miss this cool work at the interface of AI and protein structures 😎

Read and subscribe 👉 plentyofroom.beehiiv.com/p/ai-powered...

AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements!

AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 28

400 million tonnes of plastic are produced each year, with tons of environmental problems.

Can DNA-based plastic be the solution? Super cool work! 🧪🖥️🧬

PS read and subscribe here 👉 plentyofroom.beehiiv.com/p/dna-plasti...

DNA Plastics: Recyclable, Biodegradable Revolution!

DNA and sugar chains create biodegradable, recyclable plastics, offering an innovative solution to global plastic pollution through groundbreaking molecular engineering.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 26

Turning plastic waste into paracetamol, using bacteria? 😲 Is there something more sci-fi? 🧪

But yeah, now it's possible!
Read all about it here 👉👉 plentyofroom.beehiiv.com/p/synbio-bre...

Synbio Breakthrough: Turning Plastic Bottles into Life-Saving Drugs!

Synthetic biology transforms plastic waste into life-saving drugs, showcasing innovative chemistry that turns environmental challenges into medical breakthroughs.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 22

Is AI joining the CRISPR chat?

CRISPR-GPT is a new AI-collaboration tool created to make the design of gene editing experiments as easy as possible!

Is this the future of science? 🤔🧪
Subscribe to get more like this plentyofroom.beehiiv.com/p/ai-joins-t...

AI Joins The Crispr Chat: AI Gene Editing Revolution!

AI-powered CRISPR-GPT transforms gene editing, introducing a conversational AI co-pilot that makes genetic modification more accessible and intuitive for researchers.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 21

What do emus (yeah, the bird!) and protein dynamics have in common? 🧪

More than you would expect! Don't miss this cool work at the interface of AI and protein structures 😎

Read and subscribe 👉 plentyofroom.beehiiv.com/p/ai-powered...

AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements!

AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.

plentyofroom.beehiiv.com

3

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 20

Light up the membrane! 💡🧪🧬🖥️

Transmembrane proteins are membrane gatekeepers, but designing new functional ones is hard.

This paper applies the power of ML to create transmembrane proteins that can bind small molecules and fluoresce 🏮

Read and subscribe! 👉 plentyofroom.beehiiv.com/p/ai-designe...

AI-Designed Transmembrane Proteins: Glowing Cellular Membranes!

AI design creates fluorescent transmembrane proteins, revealing cellular interactions through innovative molecular engineering and small molecule probes.

plentyofroom.beehiiv.com

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Reposted by Plenty of Room - Newsletter

Carl T. Bergstrom @carlbergstrom.com · Aug 12

1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said."

It's literally a vital feature of both science and of representative democracy.

I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.

RFK Jr. in interview with Scripps News: ‘Trusting the experts is not science’

HHS Secretary RFK Jr. sat down with Scripps News for a wide-ranging interview, discussing mRNA vaccine funding policy changes and a recent shooting at the Centers for Disease Control and Prevention.

www.scrippsnews.com

540 2.8K 10K

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 8

Emus and protein science?
Proteins are dynamic, but it's hard to study their transitions 🧪🖥️🧬

BioEmu uses machine learning to emulate protein dynamics with high precision and speed!

It complements simulations: first test with BioEmu, then continue with MD.

Read and subscribe tinyurl.com/enf5apzc

AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements!

AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.

plentyofroom.beehiiv.com

5

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 5

Is there something cooler than structural biology papers? 🧪🖥️🧬
Looking at RNA structures, of course! 😎
Do we know what these RNA nanocages do? No.
Are they cool? Yes.
Did they try to use them for drug delivery? Also yes.

Subscribe and get more like this at plentyofroom.beehiiv.com/p/rna-nanoca...

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 29

Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable".

But today a new method creates binders using the power of computational methods! 🧪🖥️🧬

Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...

AI-Designed Protein Targeting: Taming Disordered Protein Chaos!

AI-powered computational design unlocks disordered protein targets, transforming our understanding of flexible molecular structures and potential therapeutic approaches.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 27

Yes it would be amazing to see more targeting of less organised proteins!

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 25

New issue is here 🎉

Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable".

But today a new method creates binders using the power of computational methods! 🧪🖥️🧬

Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...

AI-Designed Protein Targeting: Taming Disordered Protein Chaos!

AI-powered computational design unlocks disordered protein targets, transforming our understanding of flexible molecular structures and potential therapeutic approaches.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 20

Do you want to save your data in DNA? Well, now is coming closer!

This amazing work from University of Washington and Microsoft explore how to use CRISPR-Cas9 to access data in DNA databases. Cool! 🧪🧬🖥️

Read the whole breakdown here 👉 plentyofroom.beehiiv.com/p/crispr-bas...

CRISPR-Based Data Storage: DNA Search Engine Revolution!

CRISPR-Cas9 breakthrough: Innovative DNA data storage and retrieval method uses genetic engineering to transform digital information archiving.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 15

Is it possible to leverage AI to create functional RNAs?

Well, from now yes! 🧪
Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

AI RNA Design: Generating Functional Molecules with Machine Learning!

AI RNA design: Advanced machine learning techniques create functional RNA molecules, from CRISPR guides to innovative toehold switches.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 11

Just in case you missed this super cool paper 😎🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 10

Bacteria turning plastic into drugs? Oh yeah!

Sometimes bacteria aren't enough to solve problems. What about merging biocompatible chemistry and bacteria to turn plastic bottles into paracetamol? 🧪🖥️🧬

Want to get more like this? Just subscribe! 👉 plentyofroom.beehiiv.com/p/synbio-bre...
#chemistry

Synbio Breakthrough: Turning Plastic Bottles into Life-Saving Drugs!

Synthetic biology transforms plastic waste into life-saving drugs, showcasing innovative chemistry that turns environmental challenges into medical breakthroughs.

plentyofroom.beehiiv.com

2 6

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 10

Yes that's a huge problem!

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 10

Bacteria turning plastic into drugs? Oh yeah!

Sometimes bacteria aren't enough to solve problems. What about merging biocompatible chemistry and bacteria to turn plastic bottles into paracetamol? 🧪🖥️🧬

Want to get more like this? Just subscribe! 👉 plentyofroom.beehiiv.com/p/synbio-bre...
#chemistry

Synbio Breakthrough: Turning Plastic Bottles into Life-Saving Drugs!

Synthetic biology transforms plastic waste into life-saving drugs, showcasing innovative chemistry that turns environmental challenges into medical breakthroughs.

plentyofroom.beehiiv.com

2 6 11

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 9

Gene editing is moving from the lab to the clinic, but delivering gene-sized DNA is still a problem.

Today's paper evolved new CRISPR-associated transposons using phage-assisted evolution! 🧪

Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/gene-editi... #biotech #genomeediting

Gene Editing Advancement: 200x Improvement in DNA Insertion!

Gene editing revolution: Researchers develop advanced CRISPR-associated transposons, achieving 200x improvement in DNA insertion for genome modification.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 9

What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪

Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai

Computational Protein Design: Regenerative Medicine's Healing Future!

Computational protein design revolutionizes regenerative medicine, engineering innovative biomaterials and scaffolds to guide tissue regeneration like sci-fi healing techniques.

tinyurl.com

2

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 4

Don't miss this cool work! 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 3

Finding new drugs is hard. Even more for macrocycles, the molecules that could be the new best thing in medicine!

🧪Enter RFpeptides, a machine learning pipeline for macrocycle binders! Great work from @uwproteindesign.bsky.social
Want more like this? 👉 tinyurl.com/2da2k8dy
#biotech #ML #AI 🧬🖥️

AI Macrocycle Design: Revolutionizing Drug Discovery with Machine Learning!

AI-powered protein design creates macrocycles, leveraging machine learning to generate novel drug candidates and transform molecular engineering approaches.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 3

Finding new drugs is hard. Even more for macrocycles, the molecules that could be the new best thing in medicine!

🧪Enter RFpeptides, a machine learning pipeline for macrocycle binders! Great work from @uwproteindesign.bsky.social
Want more like this? 👉 tinyurl.com/2da2k8dy
#biotech #ML #AI 🧬🖥️

AI Macrocycle Design: Revolutionizing Drug Discovery with Machine Learning!

AI-powered protein design creates macrocycles, leveraging machine learning to generate novel drug candidates and transform molecular engineering approaches.

plentyofroom.beehiiv.com

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Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jun 29

Nothing to read on Sunday? I got you covered!

What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪

Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai

Computational Protein Design: Regenerative Medicine's Healing Future!

Computational protein design revolutionizes regenerative medicine, engineering innovative biomaterials and scaffolds to guide tissue regeneration like sci-fi healing techniques.

tinyurl.com

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