Lightnews — Scholar-powered news

Paola A. Marignani @pmarignani.bsky.social · 13h

Metal-organic framework! Nobel for Chemistry. Fantastic news this morning.

Nature @nature.com · 14h

BREAKING: The Nobel Prize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal-organic frameworks”

Stay tuned for more.
#NobelPrize

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Reposted by Paola A. Marignani

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Paola A. Marignani @pmarignani.bsky.social · 6d

FoM Town Hall-Strategic Focus

"What can we do to generate revenue" Dean Anderson Oct 2, 2025

@dalhousieu.bsky.social

Paola A. Marignani @pmarignani.bsky.social · 8d

Today I honour the Survivors of residential schools and remember the children who never came home. Reconciliation means listening, learning, and doing better. To Survivours: your stories matter, your resilience inspires. #Truth #Reconciliation #NDTR

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Paola A. Marignani @pmarignani.bsky.social · 9d

Thank you Aya !
Your support has been impactful.
#ScienceIsFun

Aya @ayalan.bsky.social · 9d

Dr. Marignani's example has had a profound influence on me and countless others who have benefited from her generosity, mentorship, and passion for science. Congrats @pmarignani.bsky.social @dalhousie.bsky.social for being selected as a finalist for the Discovery Award Science Champion! 👩‍🔬

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Reposted by Paola A. Marignani

McManusLab @kirkmcmanuslab.bsky.social · 12d

🚀 Exciting MSc opp @ UManitoba! Join 2 interdisciplinary labs (bioinformatics + cancer bio) on a CIHR-funded ovarian cancer project. Gain hands-on training in single-cell genomics & molecular biology. See advertisement to apply #GradResearch #Cancer

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Paola A. Marignani @pmarignani.bsky.social · 14d

Public service announcement.

Paola A. Marignani @pmarignani.bsky.social · 15d

@dalhousieu.bsky.social Please consider welcoming Italians 🇮🇹 onto campus.

Benvenuti works well.

Paola A. Marignani @pmarignani.bsky.social · 16d

Dr. Chris McMaster shares his insight and experiences with biotech start-ups, innovation and commercialization. @dalinnovates.bsky.social

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Paola A. Marignani @pmarignani.bsky.social · 16d

Gentle reminder for those of you searching for scholarships.

Remember to search your university website for scholarship opportunities, provincial and federal government websites.

Paola A. Marignani @pmarignani.bsky.social · Aug 29

Evening ocean kayaking. East coast calm.

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Paola A. Marignani @pmarignani.bsky.social · Aug 27

Excited 2 invite those of you attending The International Association for the Study of Lung Cancer Conference to the workshop I organized. A wonderful opportunity 2 learn how cutting-edge innovations are translated 2 clinical practice
#WCLC2025 #IASLC

cattendee.abstractsonline.com/meeting/2115...

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Paola A. Marignani @pmarignani.bsky.social · Aug 19

Webinar detailing new Tri-Council CV.

youtu.be/xeAk9Co8D2M?...

Tri-agency CV webinar

YouTube video by CIHR IRSC

youtu.be

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Paola A. Marignani @pmarignani.bsky.social · Aug 19

☀️☕👩🏻‍💻 Shifting from Immunohistochemistry to Screen for ALK Rearrangements: Real-World Experience in a Large Single-Center Cohort of Patients with NSCLC
www.mdpi.com/2072-6694/16...

www.mdpi.com

Paola A. Marignani @pmarignani.bsky.social · Aug 17

Finally made it back to reformer Pilates at Iness new location at 2800 Argyle Street, Halifax.

My bones will thank me tomorrow.

Congrat Christy for your new location.

🧘🏻‍♀️🤸🏻‍♀️
www.iness.ca?gad_source=1...

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Paola A. Marignani @pmarignani.bsky.social · Aug 15

Great opportunity for biotech wetlab biotech startup space. Check it out.

Athanor Scientific Inc. @athanorscientific.bsky.social · Aug 15

🍁👩‍🔬 Are you seeking wet lab space for your biotech startup or commercialized venture? We're exploring a pilot program to support 'biotech startups in residence,' offering reduced-cost resources and lab space to scientists and researchers.

Expression of interest form: forms.gle/ovjAEuXatigp...

Need wet lab space? Take this survey about our pilot Biotech Startup in Residence program.

Thank you for your interest in our biotech wet lab space survey. We are exploring the establishment of a shared wet lab facility on the campus of an independent grade-school in British Columbia, Canad...

forms.gle

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Reposted by Paola A. Marignani

LKB1 (STK11) @stk11.bsky.social · Mar 12

Conclusions:
EDD E3 ubiquitin ligase levels increase progressively with BC progression.
EDD critical in regulating cell cycle progression & apoptosis; involved in promoting TORC1 signaling.
EDD knockdown in MCF-7 and T47D result in G2-phase arrest, decreased cell viability, and increased apoptosis.

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Reposted by Paola A. Marignani

LKB1 (STK11) @stk11.bsky.social · Mar 12

EDD protein levels were assessed through immunostaining techniques in various breast tissue samples, including benign tissues and different grades of ductal carcinoma. This method helped establish the correlation between EDD expression and breast cancer progression. 📝

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Reposted by Paola A. Marignani

LKB1 (STK11) @stk11.bsky.social · Mar 12

EDD is a gene induced by PRL in human BCa cells, suggesting a link between hormonal signaling and cancer progression

pubmed.ncbi.nlm.nih.gov/31392083/

#TORC1 #apoptosis #breastcancer #prolactin

Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells - PubMed

Previously, we identified a prolactin (PRL)-inducible gene encoding EDD E3 ubiquitin ligase in human breast cancer (BCa) cells. We reported that EDD binds the mTOR (TORC1)-associated α4 phosphoprotein...

pubmed.ncbi.nlm.nih.gov

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Paola A. Marignani @pmarignani.bsky.social · Aug 15

Impressive cell dance! Guided by a lethal mutation in PI3K that drives malignancy.

Nature can be both beautiful and haunting at the same time.

LKB1 (STK11) @stk11.bsky.social · Mar 13

Fantastic and haunting imagery.

Lucien Hinderling @lhinderling.bsky.social · Nov 10

This dance kills people! Human breast cells with a PI3K mutation showing coordinated cell movement.

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Paola A. Marignani @pmarignani.bsky.social · Aug 13

Happy to share our Resources section at @cdnwomenstem.bsky.social

Canadian Women in STEM @cdnwomenstem.bsky.social · Aug 13

Check out our new Resources section!

canadianwomeninstem.org/resources/

Canadian Women in STEM - Resources

canadianwomeninstem.org

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Paola A. Marignani @pmarignani.bsky.social · Aug 8

.....not sure why the @dalhousieu.bsky.social internal deadline to upload to ResearchNet is Aug26. Two weeks prior to CIHR deadline.

DM me with your thoughts.

Paola A. Marignani @pmarignani.bsky.social · Aug 7

@dalhousieu.bsky.social is attempting to block my submission of a competitive LOI to a non-tricouncil agency.

Given the poor grant capture success of Dal, should they be blocking an LOI?

Our successful grants bring overhead that support their salaries🤔

DM your thoughts.

Paola A. Marignani @pmarignani.bsky.social · Aug 7

😞☕👩🏻‍💻
www.1015thehawk.com/2025/08/06/1...

1K Dalhousie faculty members could be locked out by next week

More than 1,000 faculty members at the largest university in Nova Scotia could be locked out or in legal strik...

www.1015thehawk.com

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Paola A. Marignani @pmarignani.bsky.social · Jul 24

☀️☕👩🏻‍💻 ATR promotes mTORC1 activity via de novo cholesterol synthesis | EMBO reports www.embopress.org/doi/full/10....

ATR promotes mTORC1 activity via de novo cholesterol synthesis | EMBO reports

imageimageATR activates mTORC1 by increasing phosphorylation and expression of the de novo cholesterol synthesis enzyme lanosterol synthase in cancer cells. While ATM activates mTORC1 via TSC1/2, ATR’...

www.embopress.org

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