Watch the full episode and view show notes here: https://bit.ly/3LCmXHD Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Rhonda Patrick, Ph.D., is a scientist with expertise in the areas of aging, cancer, and nutrition who translates complex scientific topics into actionable insights on her podcast, Found My Fitness. In this episode, Rhonda provides her latest thinking as it relates to Alzheimer's disease including the possibility of a vascular hypothesis as well as the factors that can impact disease risk such as type 2 diabetes, blood pressure, omega supplementation, exercise, sauna, and more. She also touches on cancer risk including the relationship between cancer and exercise as well as the link between alcohol consumption and cancer. Additionally, Rhonda explains her new focus on exercise and protein consumption as well as how her perspective has shifted as it pertains to fasting and time-restricted feeding. We discuss: 0:00:00 - Intro 0:00:38 - Alzheimer’s disease: Rhonda’s evolved thinking on neurodegenerative diseases 0:08:00 - The breakdown of the blood-brain barrier in neurodegenerative disease 0:16:03 - An explanation for the observation that type 2 diabetes increases risk of Alzheimer’s disease 0:20:53 - The role of omega-3 fatty acids (EPA and DHA) in brain health and prevention of neurodegeneration 0:35:30 - Comparing the preventable nature of type 2 diabetes, atherosclerosis, cancer, and dementia 0:38:53 - Blood pressure: an important modifiable lifestyle factor that can affect Alzheimer's disease risk 0:43:08 - Rhonda’s outlook on “precision medicine” as it pertains to one’s genetic predispositions 0:51:28 - Possible mechanisms by which exercise reduces the risk of Alzheimer’s disease 1:01:09 - Building your aerobic pyramid: neurobiological effects of exercise, benefits of lactate peaks, and more 1:06:55 - Maximizing mitochondrial biogenesis: alternative training approaches and strategies 1:19:44 - Possible brain benefits of sauna, and Rhonda’s personal protocol 1:27:30 - The relationship between cardiorespiratory fitness and dementia risk 1:33:45 - How exercise may reduce the risk of cancer 1:49:09 - The overarching impact of exercise of health, and the importance of focusing the factors that matter most 1:55:07 - Impact of alcohol consumption on breast cancer risk and overall health 2:00:45 - Exercise as an intervention for poor sleep habits 2:05:25 - The longevity benefits of consuming adequate protein and strength training to preserve muscle mass and strength 2:27:15 - How to get enough of the right kind of protein in your diet 2:35:35 - Fasting: weighing the risk vs. reward 2:39:38 - How Rhonda’s views have shifted on diet and exercise 2:46:17 - How to follow Rhonda’s work and more about the benefits of lactate for the brain -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.