Post-Viral Trials
@postviraltrials.bsky.social
News and information about interventional trials for Long Covid, ME/CFS, POTS, and other post-viral illnesses. Message or tag me if you’re in a trial or otherwise have information to share.
Bleak…even a world-famous NBA player doesn’t get more than salt. Somebody get this man an appointment with a real doctor! Mestinon, tVNS, IVIg…something more than salt and exerc—er, oh, you’re a professional athlete you say? Then, uh, rest! www.nytimes.com/athletic/673...
October 26, 2025 at 1:44 PM
Bleak…even a world-famous NBA player doesn’t get more than salt. Somebody get this man an appointment with a real doctor! Mestinon, tVNS, IVIg…something more than salt and exerc—er, oh, you’re a professional athlete you say? Then, uh, rest! www.nytimes.com/athletic/673...
Some details on the Japanese rituximab trial, corroborated in the post below
August 4, 2025 at 4:08 PM
Some details on the Japanese rituximab trial, corroborated in the post below
Just watched the end of this from a while back. Based on this timeline, it looks like we won’t get results until 2027 at the earliest. Very exciting trial though.
July 29, 2025 at 12:56 AM
Just watched the end of this from a while back. Based on this timeline, it looks like we won’t get results until 2027 at the earliest. Very exciting trial though.
Actually I realized I was not setting it properly (I think it resets after the battery dies). Here are the ones I use: www.sciencedirect.com/science/arti...
March 19, 2025 at 1:25 PM
Actually I realized I was not setting it properly (I think it resets after the battery dies). Here are the ones I use: www.sciencedirect.com/science/arti...
Here’s mine at the settings I do (I picked them from a different study with a positive result), I use it for an hour every day. You first pick the pulse width and frequency, and then set the amperage. You can do left or right ear, or both (I do left since that’s historically what’s been recommended)
March 18, 2025 at 3:50 PM
Here’s mine at the settings I do (I picked them from a different study with a positive result), I use it for an hour every day. You first pick the pulse width and frequency, and then set the amperage. You can do left or right ear, or both (I do left since that’s historically what’s been recommended)
A phase 2 RCT of plitidepsin for Long Covid has launched at Germans Trias Hospital in Barcelona. They are looking to enroll 90 patients, and the participation criteria are broad clinicaltrials.gov/study/NCT067...
January 30, 2025 at 3:22 PM
A phase 2 RCT of plitidepsin for Long Covid has launched at Germans Trias Hospital in Barcelona. They are looking to enroll 90 patients, and the participation criteria are broad clinicaltrials.gov/study/NCT067...
January 19, 2025 at 1:30 PM
Non-controlled study of repeat immunoadsorption in post-Covid ME/CFS patients found a significant improvement in physical functioning (+17.75 on SF36 PF among all patients at 4 weeks), fatigue, PEM, pain, cognitive, autonomic, and immunological symptoms. RCTs ongoing in post- and non-Covid patients.
December 14, 2024 at 2:52 PM
Non-controlled study of repeat immunoadsorption in post-Covid ME/CFS patients found a significant improvement in physical functioning (+17.75 on SF36 PF among all patients at 4 weeks), fatigue, PEM, pain, cognitive, autonomic, and immunological symptoms. RCTs ongoing in post- and non-Covid patients.
It was a proof-of-concept trial – cheaper to run than a RCT when you’re iffy on its chances for success x.com/humanmanifol...
November 27, 2024 at 3:56 PM
It was a proof-of-concept trial – cheaper to run than a RCT when you’re iffy on its chances for success x.com/humanmanifol...
From @scheibenbogen.bsky.social’s presentation, I think these are further results from this case-controlled immunoadsorption study (pmc.ncbi.nlm.nih.gov/articles/PMC...) of LC pts w/high β2-agAAbs (Schmerz = pain; Alltagsfunktion = everyday function), publication forthcoming x.com/humanmanifol...
November 26, 2024 at 3:46 PM
From @scheibenbogen.bsky.social’s presentation, I think these are further results from this case-controlled immunoadsorption study (pmc.ncbi.nlm.nih.gov/articles/PMC...) of LC pts w/high β2-agAAbs (Schmerz = pain; Alltagsfunktion = everyday function), publication forthcoming x.com/humanmanifol...
It’s not public, but apparently a preliminary analysis from Dr. Bettina Hohberger’s BC007 trial showed some positive result, according to some German patients from X. This is contrary to the recently announced results from the drugmaker’s own trial. x.com/_trans4m8tio...
November 25, 2024 at 8:42 PM
It’s not public, but apparently a preliminary analysis from Dr. Bettina Hohberger’s BC007 trial showed some positive result, according to some German patients from X. This is contrary to the recently announced results from the drugmaker’s own trial. x.com/_trans4m8tio...
And in rabbits: pubmed.ncbi.nlm.nih.gov/35118574/
November 21, 2024 at 6:05 PM
And in rabbits: pubmed.ncbi.nlm.nih.gov/35118574/
Here’s the one in humans: www.sciencedirect.com/science/arti...
November 21, 2024 at 6:02 PM
Here’s the one in humans: www.sciencedirect.com/science/arti...
Confusing: there are two “collaborative sites” listed at Penn and Yale, but the sign-up form at redcap.vumc.org/surveys/?s=3... only lists the four enrolling sites. If you want the Yale or Penn sites, I’d recommend clicking Vanderbilt and seeing what they say when they contact you
November 18, 2024 at 7:38 PM
Confusing: there are two “collaborative sites” listed at Penn and Yale, but the sign-up form at redcap.vumc.org/surveys/?s=3... only lists the four enrolling sites. If you want the Yale or Penn sites, I’d recommend clicking Vanderbilt and seeing what they say when they contact you
My overnight HRV having Covid for the second time vs. Trump winning an election for the second time
November 10, 2024 at 12:42 AM
My overnight HRV having Covid for the second time vs. Trump winning an election for the second time
Michael Peluso says that AER002 results will be out in 1-2 months
November 9, 2024 at 1:02 AM
Michael Peluso says that AER002 results will be out in 1-2 months
Trials planned at the Charité in Germany:
- CD20 B-cell depletion (Ocrevus)
- CD19 B-cell depletion (Uplizna)
- Immunoadsorption in ME/CFS
- Immunoadsorption in Long Covid
- Abilify and dexamphetamine (an ingredient in Adderall, once called speed)
x.com/lisathefirst...
- CD20 B-cell depletion (Ocrevus)
- CD19 B-cell depletion (Uplizna)
- Immunoadsorption in ME/CFS
- Immunoadsorption in Long Covid
- Abilify and dexamphetamine (an ingredient in Adderall, once called speed)
x.com/lisathefirst...
November 7, 2024 at 3:45 PM
Trials planned at the Charité in Germany:
- CD20 B-cell depletion (Ocrevus)
- CD19 B-cell depletion (Uplizna)
- Immunoadsorption in ME/CFS
- Immunoadsorption in Long Covid
- Abilify and dexamphetamine (an ingredient in Adderall, once called speed)
x.com/lisathefirst...
- CD20 B-cell depletion (Ocrevus)
- CD19 B-cell depletion (Uplizna)
- Immunoadsorption in ME/CFS
- Immunoadsorption in Long Covid
- Abilify and dexamphetamine (an ingredient in Adderall, once called speed)
x.com/lisathefirst...
Rob Wüst will be doing a phase 2 trial of Sonlicromanol for post-Covid PEM, funded by ZonMw vu.nl/nl/nieuws/20... x.com/robwust/stat...
November 6, 2024 at 8:47 PM
Rob Wüst will be doing a phase 2 trial of Sonlicromanol for post-Covid PEM, funded by ZonMw vu.nl/nl/nieuws/20... x.com/robwust/stat...
…and I was also having a hard time sleeping. I decided to start a physical therapy program that is, basically, a very slow, patient-responsive ramp-up towards the CHOP protocol. As soon as I started doing something that resembled exercise, I got a boost in energy and my HRV started rising.
November 6, 2024 at 5:21 PM
…and I was also having a hard time sleeping. I decided to start a physical therapy program that is, basically, a very slow, patient-responsive ramp-up towards the CHOP protocol. As soon as I started doing something that resembled exercise, I got a boost in energy and my HRV started rising.
Dysautonomia International has put out a call for proposals for $1.1 million in funding, due this Friday: dysautonomiainternational.salsalabs.org/2024grantfun...
November 4, 2024 at 5:07 PM
Dysautonomia International has put out a call for proposals for $1.1 million in funding, due this Friday: dysautonomiainternational.salsalabs.org/2024grantfun...